ChemicalBook > CAS DataBase List > 2-Amino-6-fluorobenzoic acid

2-Amino-6-fluorobenzoic acid

Product Name
2-Amino-6-fluorobenzoic acid
CAS No.
434-76-4
Chemical Name
2-Amino-6-fluorobenzoic acid
Synonyms
6-FABA;BUTTPARK 44\01-59;TIMTEC-BB SBB006549;RARECHEM AL BO 0279;2-Amino-6-Fluorobenzoic;6-FLUOROANTHRANILIC ACID;2-amino-6-fluorobenzoate;6-FluoroanthranilicAcid>2-aMino-6-flourobenzoicacid;2-AMINO-6-FLUOROBENZOIC ACID
CBNumber
CB4351052
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
434-76-4.mol
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2-Amino-6-fluorobenzoic acid Property

Melting point:
167-169 °C (lit.)
Boiling point:
223.67°C (rough estimate)
Density 
1.3021 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
4.01±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow to brown
BRN 
3540926
InChIKey
RWSFZKWMVWPDGZ-UHFFFAOYSA-N
CAS DataBase Reference
434-76-4(CAS DataBase Reference)
NIST Chemistry Reference
Anthralic acid, 6-fluoro-(434-76-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
443026
Product name
2-Amino-6-fluorobenzoic acid
Purity
98%
Packaging
5g
Price
$30.8
Updated
2023/01/07
TCI Chemical
Product number
F0475
Product name
6-Fluoroanthranilic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
F0475
Product name
6-Fluoroanthranilic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$87
Updated
2024/03/01
Alfa Aesar
Product number
A10919
Product name
2-Amino-6-fluorobenzoic acid, 98%
Packaging
1g
Price
$34.65
Updated
2024/03/01
Alfa Aesar
Product number
A10919
Product name
2-Amino-6-fluorobenzoic acid, 98%
Packaging
5g
Price
$114.65
Updated
2024/03/01
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2-Amino-6-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.

Definition

ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid.

reaction suitability

reaction type: solution phase peptide synthesis

storage

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Synthesis

The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.

2-Amino-6-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-fluorobenzoic acid Suppliers

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View Lastest Price from 2-Amino-6-fluorobenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-24
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $0.10/KG
Min. Order
0.1KG
Purity
98%
Supply Ability
200TONS
Release date
2019-12-24
Honest Joy Holdings Limited
Product
2-Amino-6-fluorobenzoic acid 434-76-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-02-20

434-76-4, 2-Amino-6-fluorobenzoic acidRelated Search:

Urethane 4-Aminobenzoic acid 4-Fluorobenzoic acid POLYURETHANE Glycine 6-Aminocaproic acid 2-AMINO-3,5-DIBROMO-6-FLUOROBENZOIC ACID 2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID 2-AMINO-3,4,5,6-TETRAFLUOROBENZOIC ACID 2-Amino-4-Fluorobenzoic Acid 99%,2-AMINO-4-FLUOROBENZOIC ACID / 4-FLUOROANTHRANILIC ACID,2-AMINO-4-FLUOROBENZOIC ACID Anthranilic acid 2-AMINO-6-FLUORO-3-NITROBENZOIC ACID ETHYL ESTER 2-Fluoro-6-nitrobenzoic acid 3-AMINO-2,5,6-TRIFLUOROBENZOIC ACID 3-FLUORO-5-METHYLBENZYL ALCOHOL 4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid 2-BROMO-5-FLUORO-4-METHYLBENZALDEHYDE 2-Amino-5-fluorobenzoic acid

  • BUTTPARK 44\01-59
  • 6-FLUOROANTHRANILIC ACID
  • 2-fluoro-6-aminobenzoic acid
  • TRIPHENYLBORANE, 0.25M SOLUTION IN TETRA
  • 2-AMINO-6-FLUOROBENZOIC ACID (6-FLUOROANTHRANILIC ACID)
  • 2-Amino-6-fluorobenzoic acid, 98% (6-Fluoroanthranilic acid)
  • 2-Amino-6-Fluorobenzoic
  • 2-Amino-6-fluorobenzoic acid 97%
  • RARECHEM AL BO 0279
  • TIMTEC-BB SBB006549
  • 2-AMINO-6-FLUOROBENZOIC ACID
  • 6-FABA (6-Fluoroanthranilic Acid)
  • 2-Amino-6-fluorobenzoicacid97%
  • 2-Amino-6-fluorobenzoic acid,98%
  • 2-aMino-6-flourobenzoicacid
  • 6-Fluoroanthranilic acid, 2-Carboxy-3-fluoroaniline
  • 2-AMino-6-fluorobenzoic acid, 98% 1GR
  • 2-AMino-6-fluorobenzoic acid SynonyMs 6-Fluoroanthranilic acid
  • Benzoicacid, 2-aMino-6-fluoro-
  • 6-FABA
  • 6-FluoroanthranilicAcid&gt
  • 2-aMino-6-flourobenzoicacid,2-fluoro-6-aminobenzoic acid,6-FLUOROANTHRANILIC ACID,methyl 2-amino-6-fluoro-5-methylbenzoate,2-Amino-6-
  • 2-amino-6-fluorobenzoate
  • 434-76-4
  • 1134-76-4
  • 437-76-4
  • 424-76-4
  • CARBOXYLIC ACID
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzoic acid
  • Fluorin-contained Benzoic acid series