2-Amino-6-fluorobenzoic acid
- Product Name
- 2-Amino-6-fluorobenzoic acid
- CAS No.
- 434-76-4
- Chemical Name
- 2-Amino-6-fluorobenzoic acid
- Synonyms
- 6-FABA;BUTTPARK 44\01-59;TIMTEC-BB SBB006549;RARECHEM AL BO 0279;2-Amino-6-Fluorobenzoic;6-FLUOROANTHRANILIC ACID;2-amino-6-fluorobenzoate;6-FluoroanthranilicAcid>2-aMino-6-flourobenzoicacid;2-AMINO-6-FLUOROBENZOIC ACID
- CBNumber
- CB4351052
- Molecular Formula
- C7H6FNO2
- Formula Weight
- 155.13
- MOL File
- 434-76-4.mol
2-Amino-6-fluorobenzoic acid Property
- Melting point:
- 167-169 °C (lit.)
- Boiling point:
- 223.67°C (rough estimate)
- Density
- 1.3021 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 4.01±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow to brown
- BRN
- 3540926
- InChIKey
- RWSFZKWMVWPDGZ-UHFFFAOYSA-N
- CAS DataBase Reference
- 434-76-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Anthralic acid, 6-fluoro-(434-76-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 443026
- Product name
- 2-Amino-6-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $30.8
- Updated
- 2023/01/07
- Product number
- F0475
- Product name
- 6-Fluoroanthranilic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- F0475
- Product name
- 6-Fluoroanthranilic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $87
- Updated
- 2024/03/01
- Product number
- A10919
- Product name
- 2-Amino-6-fluorobenzoic acid, 98%
- Packaging
- 1g
- Price
- $34.65
- Updated
- 2024/03/01
- Product number
- A10919
- Product name
- 2-Amino-6-fluorobenzoic acid, 98%
- Packaging
- 5g
- Price
- $114.65
- Updated
- 2024/03/01
2-Amino-6-fluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.
Definition
ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid.
storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Synthesis
The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.
2-Amino-6-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-6-fluorobenzoic acid manufacturers
- Product
- 2-Amino-6-fluorobenzoic acid 434-76-4
- Price
- US $0.10/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2019-12-24
- Product
- 2-Amino-6-fluorobenzoic acid 434-76-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2-Amino-6-fluorobenzoic acid 434-76-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20