2-Amino-5-fluorobenzoic acid

Product Name: 2-Amino-5-fluorobenzoic acid
CAS No.: 446-08-2
Chemical Name: 2-Amino-5-fluorobenzoic acid
Synonyms: 5-FLUOROANTHRANILIC ACID;5-FAA;NSC 513308;AURORA KA-5382;BUTTPARK 19\04-54;RARECHEM AL BO 2236;5-Fluoranthranilsure;5-fluoroanthranilicaci;Zavegepant Impurity 74;2-Amino-5-fluorobenzoic
CBNumber: CB2136554
Molecular Formula: C7H6FNO2
Formula Weight: 155.13
MOL File: 446-08-2.mol

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2-Amino-5-fluorobenzoic acid Property

Melting point:: 181-183 °C(lit.)
Boiling point:: 223.67°C (rough estimate)
Density: 1.3021 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.86±0.10(Predicted)
form: Fine Crystalline Powder
color: Light yellow to light brown
BRN: 2803664
Major Application: peptide synthesis
InChI: InChI=1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey: FPQMGQZTBWIHDN-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(F)=CC=C1N
CAS DataBase Reference: 446-08-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 367982
Product name: 2-Amino-5-fluorobenzoic acid
Purity: 97%
Packaging: 1g
Price: $59.62
Updated: 2025/07/31

Sigma-Aldrich

Product number: 367982
Product name: 2-Amino-5-fluorobenzoic acid
Purity: 97%
Packaging: 10g
Price: $473
Updated: 2025/07/31

TCI Chemical

Product number: F0396
Product name: 5-Fluoroanthranilic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: F0396
Product name: 5-Fluoroanthranilic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $170
Updated: 2025/07/31

Cayman Chemical

Product number: 16669
Product name: 2-Amino-5-fluorobenzoic Acid
Purity: ≥98%
Packaging: 1g
Price: $49
Updated: 2024/03/01

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2-Amino-5-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Used in the synthesis of styrylquinazolinones which are potential anticancer agents.

Uses

2-Amino-5-fluorobenzoic acid is used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.

Definition

ChEBI: An aminobenzoic acid that is anthranilic acid in which the hydrogen at position 5 on the phenyl ring is replaced by fluorine.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

320-98-9

446-08-2

General procedure for the synthesis of 2-amino-5-fluorobenzoic acid from 2-nitro-5-fluorobenzoic acid: 2-nitro-5-fluorobenzoic acid (10 g, 54 mmol) was dissolved in ethanol (100 mL) and 10% Pd/C catalyst (0.5 g) was added. The reaction was stirred at room temperature for 4 h under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration. The filtrate was concentrated under reduced pressure to give 8.2 g (98% yield) of the white solid product 2-amino-5-fluorobenzoic acid. Product melting point: 142 °C. 1H NMR (DMSO-d6) δ: 6.71 (dd, J = 4.9, 8.9 Hz, 1H), 7.15 (dt, J = 2.9, 8.4 Hz, 1H), 7.37 (dd, J = 2.9, 9.8 Hz, 1H), 8.60 (s, 1H).EIMS m/z 156 (M + 1).

References

[1] Patent: WO2004/74218, 2004, A2. Location in patent: Page 106
[2] Patent: US2008/139551, 2008, A1. Location in patent: Page/Page column 43
[3] Patent: US2008/139551, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: US5514676, 1996, A
[5] Journal of Biological Chemistry, 1954, vol. 207, p. 411,412

2-Amino-5-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-fluorobenzoic acid Suppliers

Americas 1 Austria 1 Belgium 2 Canada 1 China 333 Europe 3 France 2 Germany 9 India 17 Italy 1 Japan 3 Slovakia 1 Switzerland 3 Ukraine 3 United Kingdom 25 United States 53 Global 458

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View Lastest Price from 2-Amino-5-fluorobenzoic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 5-Fluoroanthranilic acid 446-08-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-22

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-5-fluorobenzoic acid 446-08-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-5-fluorobenzoic acid 446-08-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

446-08-2, 2-Amino-5-fluorobenzoic acidRelated Search:

Glycine Urethane Folic acid 4-Fluorobenzoic acid 6-Aminocaproic acid 4-Aminobenzoic acid POLYURETHANE Methyl anthranilate EPA ALTRENOGEST Citric acid Ascoric Acid Anthranilic acid 2-Amino-4,5-difluorobenzoic acid 2-Amino-6-fluorobenzoic acid 97%,2-AMINO-6-FLUOROBENZOIC ACID (6-FLUOROANTHRANILIC ACID),2-Amino-6-fluorobenzoic acid, 98% (6-Fluoroanthranilic acid) 2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID 2-AMINO-3,4,5,6-TETRAFLUOROBENZOIC ACID 4,5-Difluoro-2-nitrobenzoic acid

2-AMINO-5-FLUOROBENZOIC ACID

RARECHEM AL BO 2236

2-AMino-5-fluorobenzoic acid, 97% 1GR

NSC 513308

2-aMino-5-fluorobenzoic aicd

2-Amino-5-fluorobenzoic acid 98%

5-Fluoroanthranilic acid, 2-Carboxy-4-fluoroaniline

Anthranilic acid, 5-fluoro-

Benzoic acid, 2-amino-5-fluoro-

BUTTPARK 19\04-54

AURORA KA-5382

5-FluoroanthranilicAcid/2-Amino-5-FluorobenzoicAcid

2-Amino-5-fluoroBenzoicacid97.

2-Amino-5-fluorobenzoic Acid, 5-FAA

2-Amino-5-fluorobenzoic

5-FLUOROANTHRANILIC ACID

5-FAA

2-Amino-5-fluorobenzoic acid 97.5%

2-AMINO-5-FLUOROBENZOIC ACID 99+%

5-FLUOROANTHRANILIC ACID 98+%

5-Fluoroanthanilic acid

2-Amino-5-fluorobenzoic acid (5-Fluoroanthranilic acid)

2-Amino-5-fluorobenzoic acid, 98+%

2-Amino-5-fluorobenzoic Acid See: F587750

5-FluoroanthranilicAcid&gt

5-Fluoranthranilsure

2-Amino-5-fluorobenzoic acid,0.98

5-fluoroanthranilicaci

Zavegepant Impurity 74

446-08-2

446-8-2

466-08-2

CARBOXYLIC ACID

Aromatic Amino Acids

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Aromatics

5-FOA

Bases & Related Reagents

Nucleotides

Benzoic acid Series

Nucleotides and Nucleosides

Aromatics Compounds

Benzoic acid series

Carboxylic Acids

Phenyls & Phenyl-Het

Amines

FINE Chemical & INTERMEDIATES

Fluorobenzene

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Phenyls & Phenyl-Het

Benzoic acid

Fluorin-contained Benzoic acid series

Fluorine series