2-Amino-4,5-difluorobenzoic acid
- Product Name
- 2-Amino-4,5-difluorobenzoic acid
- CAS No.
- 83506-93-8
- Chemical Name
- 2-Amino-4,5-difluorobenzoic acid
- Synonyms
- BUTTPARK 49\07-41;2-Amino-4,5-difluoro;4,5-DIFLUOROANTHRANILIC ACID;4,5-DifluoroanthranilicAcid>2-AMINO-4,5-DIFLUOROBENZOIC ACID;Benzoicacid, 2-aMino-4,5-difluoro-;2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic;2-Carboxy-4,5-difluoroaniline, 4,5-Difluoroanthranilic acid;2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic acid;4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid)
- CBNumber
- CB6263559
- Molecular Formula
- C7H5F2NO2
- Formula Weight
- 173.12
- MOL File
- 83506-93-8.mol
2-Amino-4,5-difluorobenzoic acid Property
- Melting point:
- 181-185 °C
- Boiling point:
- 326.8±42.0 °C(Predicted)
- Density
- 1.536±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.54±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to straw
- BRN
- 2834162
- CAS DataBase Reference
- 83506-93-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36-26
- Safety Statements
- 26-36-36/37/38
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 399760
- Product name
- 4,5-Difluoroanthranilic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $79.1
- Updated
- 2025/07/31
- Product number
- D4063
- Product name
- 4,5-Difluoroanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- D4063
- Product name
- 4,5-Difluoroanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $456
- Updated
- 2025/07/31
- Product number
- A609113
- Product name
- 2-Amino-4,5-difluorobenzoicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P380
- Product name
- 2-Amino-4,5-difluorobenzoicacid
- Packaging
- 25g
- Price
- $66
- Updated
- 2021/12/16
2-Amino-4,5-difluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Beige solid
Uses
2-Amino-4,5-difluorobenzoic acid is a benzoic acid derivative used as an intermediate in icotinib. icotinib is an effective and highly selective oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of patients with advanced non-small-cell lung cancer (NSCLC) who have failed prior chemotherapy.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
20372-63-8
83506-93-8
General procedure for the synthesis of 2-amino-4,5-difluorobenzoic acid from 4,5-difluoro-2-nitrobenzoic acid: 4,5-difluoro-2-nitrobenzoic acid (447 mg, 2.2 mmol) was added to a suspension of methanol (10 mL) containing 20% palladium/carbon hydroxide [50% (w/w) wet type, 40 mg]. The reaction mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to afford 2-amino-4,5-difluorobenzoic acid (380 mg, yield: 100%).
References
[1] Patent: WO2003/106435, 2003, A1. Location in patent: Page 290; 291; 332
2-Amino-4,5-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-4,5-difluorobenzoic acid manufacturers
- Product
- 2-Amino-4,5-difluorobenzoic acid 83506-93-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-24
- Product
- 2-Amino-4,5-difluorobenzoic acid 83506-93-8
- Price
- US $0.10/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2019-12-24
- Product
- 2-Amino-4,5-difluorobenzoic acid 83506-93-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10