2-Amino-4,5-difluorobenzoic acid

Product Name: 2-Amino-4,5-difluorobenzoic acid
CAS No.: 83506-93-8
Chemical Name: 2-Amino-4,5-difluorobenzoic acid
Synonyms: BUTTPARK 49\07-41;2-Amino-4,5-difluoro;4,5-DIFLUOROANTHRANILIC ACID;4,5-DifluoroanthranilicAcid>2-AMINO-4,5-DIFLUOROBENZOIC ACID;Benzoicacid, 2-aMino-4,5-difluoro-;2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic;2-Carboxy-4,5-difluoroaniline, 4,5-Difluoroanthranilic acid;2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic acid;4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid)
CBNumber: CB6263559
Molecular Formula: C7H5F2NO2
Formula Weight: 173.12
MOL File: 83506-93-8.mol

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2-Amino-4,5-difluorobenzoic acid Property

Melting point:: 181-185 °C
Boiling point:: 326.8±42.0 °C(Predicted)
Density: 1.536±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.54±0.10(Predicted)
form: Liquid
color: Clear colorless to straw
BRN: 2834162
Major Application: peptide synthesis
InChI: 1S/C7H5F2NO2/c8-4-1-3(7(11)12)6(10)2-5(4)9/h1-2H,10H2,(H,11,12)
InChIKey: DGOZIZVTANAGCA-UHFFFAOYSA-N
SMILES: Nc1cc(F)c(F)cc1C(O)=O
CAS DataBase Reference: 83506-93-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36-26
Safety Statements: 26-36-36/37/38
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 399760
Product name: 4,5-Difluoroanthranilic acid
Purity: 97%
Packaging: 5g
Price: $84.3
Updated: 2026/03/19

TCI Chemical

Product number: D4063
Product name: 4,5-Difluoroanthranilic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $122
Updated: 2026/03/19

TCI Chemical

Product number: D4063
Product name: 4,5-Difluoroanthranilic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $486
Updated: 2026/03/19

TRC

Product number: A609113
Product name: 2-Amino-4,5-difluorobenzoicAcid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: P380
Product name: 2-Amino-4,5-difluorobenzoicacid
Packaging: 25g
Price: $66
Updated: 2021/12/16

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2-Amino-4,5-difluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Beige solid

Uses

2-Amino-4,5-difluorobenzoic acid is a benzoic acid derivative used as an intermediate in icotinib. icotinib is an effective and highly selective oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of patients with advanced non-small-cell lung cancer (NSCLC) who have failed prior chemotherapy.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

20372-63-8

83506-93-8

General procedure for the synthesis of 2-amino-4,5-difluorobenzoic acid from 4,5-difluoro-2-nitrobenzoic acid: 4,5-difluoro-2-nitrobenzoic acid (447 mg, 2.2 mmol) was added to a suspension of methanol (10 mL) containing 20% palladium/carbon hydroxide [50% (w/w) wet type, 40 mg]. The reaction mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to afford 2-amino-4,5-difluorobenzoic acid (380 mg, yield: 100%).

References

[1] Patent: WO2003/106435, 2003, A1. Location in patent: Page 290; 291; 332

2-Amino-4,5-difluorobenzoic acid Preparation Products And Raw materials

Raw materials

Methanesulfonyl chloride 4,5-Difluorophthalic acid

Preparation Products

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2-Amino-4,5-difluorobenzoic acid Suppliers

Americas 1 China 201 Europe 3 Germany 4 India 5 Italy 1 Japan 1 Switzerland 1 Ukraine 2 United Kingdom 8 United States 32 Global 259

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View Lastest Price from 2-Amino-4,5-difluorobenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Amino-4,5-difluorobenzoic acid 83506-93-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-24

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-4,5-difluorobenzoic acid 83506-93-8
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 200TONS
Release date: 2019-12-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-4,5-difluorobenzoic acid 83506-93-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

83506-93-8, 2-Amino-4,5-difluorobenzoic acidRelated Search:

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2-AMINO-4,5-DIFLUOROBENZOIC ACID

BUTTPARK 49\07-41

4,5-DIFLUOROANTHRANILIC ACID

4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid)

2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic

2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic acid

2-Amino-4,5-difluoro

2-Carboxy-4,5-difluoroaniline, 4,5-Difluoroanthranilic acid

Benzoicacid, 2-aMino-4,5-difluoro-

4,5-DifluoroanthranilicAcid&gt

83506-93-8

C7F2H5NO2

F2C6H2NH2CO2H

C7H5F2NO2

C7H5NO2F2

Specialty Synthesis

Peptide Synthesis

Unnatural Amino Acid Derivatives

Aromatic Amino Acids

Fluorine series

Benzenes

Fluorobenzene

heterocyclic/Aliphatic series

Fluorin-contained Benzoic acid series