4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
- Product Name
- 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
- CAS No.
- 1015433-96-1
- Chemical Name
- 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
- Synonyms
- METHYL 4,5-DIFLUORO-2-NITROBENZOATE;methyl 3,4-difluoro-6-nitro benzoate;4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER;Benzoic acid, 4,5-difluoro-2-nitro-, methyl ester;4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB11485007
- Molecular Formula
- C8H5F2NO4
- Formula Weight
- 217.13
- MOL File
- 1015433-96-1.mol
4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Property
- Melting point:
- 59-63°
- Boiling point:
- 288℃
- Density
- 1.471
- Flash point:
- 128℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H5F2NO4/c1-15-8(12)4-2-5(9)6(10)3-7(4)11(13)14/h2-3H,1H3
- InChIKey
- JHWZADUIXGMAKM-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC(F)=C(F)C=C1[N+]([O-])=O
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M303773
- Product name
- Methyl4,5-Difluoro-2-nitrobenzoate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 211000
- Product name
- Methyl4,5-difluoro-2-nitrobenzoate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- PC53622
- Product name
- Methyl4,5-difluoro-2-nitro-benzoate
- Purity
- 95%
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- X4304
- Product name
- 4,5-Difluoro-2-nitrobenzoicacidmethylester
- Packaging
- 25g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- PC53622
- Product name
- Methyl4,5-difluoro-2-nitro-benzoate
- Purity
- 95%
- Packaging
- 25g
- Price
- $479
- Updated
- 2021/12/16
4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 4,5-difluoro-2-nitrobenzoate is mainly used as an intermediate in organic synthesis.
Synthesis
67-56-1
20372-63-8
1015433-96-1
Step 2 (Ib): to a solution of anhydrous methanol (MeOH, 1.0 L) of 4,5-difluoro-2-nitrobenzoic acid (Ia, 40.0 g, 196.947 mmol) was slowly added concentrated sulfuric acid (H2SO4, 60.0 mL), and the reaction mixture immediately became clear. The reaction system was heated to reflux with continuous stirring for 2 days. After completion of the reaction, methanol was removed by rotary evaporator under reduced pressure. The residue was liquefied with ethyl acetate (EtOAc) and water and the organic phase was collected. The organic phase was sequentially washed with saturated brine and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the filtrate was treated with anhydrous sodium sulfate (Na2SO4), filtered again, and the filtrate was concentrated to give methyl 4,5-difluoro-2-nitrobenzoate as a light yellow solid with a yield of 39.71 g and 93% yield.
References
[1] Patent: WO2008/36843, 2008, A2. Location in patent: Page/Page column 33
4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER manufacturers
- Product
- Methyl 4,5-difluoro-2-nitrobenzoate 1015433-96-1
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13
- Product
- Methyl 4,5-Difluoro-2-nitrobenzoate 1015433-96-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-13
- Product
- 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER 1015433-96-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25