2-Amino-5-fluorobenzoic acid methyl ester
- Product Name
- 2-Amino-5-fluorobenzoic acid methyl ester
- CAS No.
- 319-24-4
- Chemical Name
- 2-Amino-5-fluorobenzoic acid methyl ester
- Synonyms
- Methyl-5-fluoroanthranilate;Methyl 2-amino-5-fluorobenzoat;METHYL 2-AMINO-5-FLUOROBENZOATE;4-Fluoro-2-(methoxycarbonyl)aniline;2-Amino-5-fluorbenzoesuremethylester;5-Fluoroanthranilic Acid Methyl Ester;2-AMINO-5-FLUORO BENZOIC ACID METHYL ESTER;2-AMINO-5-FLUOROBENZONIC ACID METHYL ESTER;Benzoic acid, 2-amino-5-fluoro-, methyl ester;4-Fluoro-2-(methoxycarbonyl)aniline, Methyl 5-fluoroanthranilate
- CBNumber
- CB9264845
- Molecular Formula
- C8H8FNO2
- Formula Weight
- 169.15
- MOL File
- 319-24-4.mol
2-Amino-5-fluorobenzoic acid methyl ester Property
- Melting point:
- 34-37°C
- Boiling point:
- 100-102°C 0,5mm
- Density
- 1,26 g/cm3
- vapor pressure
- 10-80Pa at 20-50℃
- Flash point:
- 132°C
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.08±0.10(Predicted)
- form
- powder to lump
- color
- White to Yellow to Green
- BRN
- 2803210
- LogP
- 2.4-2.47 at 20-25℃
- Surface tension
- 53.1mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 319-24-4(CAS DataBase Reference)
Safety
- Risk Statements
- 52/53
- Safety Statements
- 22-24/25-61
- Hazard Note
- Harmful
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2899
- Product name
- Methyl 5-Fluoroanthranilate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $186
- Updated
- 2025/07/31
- Product number
- M2899
- Product name
- Methyl 5-Fluoroanthranilate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $746
- Updated
- 2025/07/31
- Product number
- M328700
- Product name
- Methyl2-amino-5-fluorobenzoate
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M328700
- Product name
- Methyl2-amino-5-fluorobenzoate
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 083365
- Product name
- Methyl 2-amino-5-fluorobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-Amino-5-fluorobenzoic acid methyl ester Chemical Properties,Usage,Production
Uses
2-Amino-5-fluorobenzoic acid methyl ester is used as an intermediate component in the preparation of hepatitis B virus (HBV) vaccines and quinazoline derivatives. It is also used in the synthesis of other organic heterocyclic compounds such as 2-aminobenzoates and α,β-unsaturated ketones.
Synthesis
67-56-1
446-08-2
319-24-4
General procedure for the synthesis of methyl 2-amino-5-fluorobenzoate from methanol and 2-amino-5-fluorobenzoic acid: 2-amino-5-fluorobenzoic acid (9.29 mmol, 1.440 g) was dissolved in 3N HCl/MeOH solution (30 mL), and heated to reflux at 100 °C overnight. Upon completion of the reaction, the solvent was removed by evaporation and the crude product was separated by extraction between dichloromethane (DCM) and saturated aqueous potassium carbonate (K2CO3). The organic phase was collected, evaporated and concentrated, and purified by silica gel (SiO2) column chromatography with hexane/ethyl acetate mixed solvent as eluent to give 0.650 g of methyl 2-amino-5-fluorobenzoate in 42% yield. The structure of the product was confirmed by 1H NMR (200 MHz, CDCl3): δ 3.9 (s, 3H), 5.6 (s, 2H), 6.6 (dd, J = 9.0, 4.7 Hz, 1H), 7.0 (m, 1H), 7.5 (dd, J = 9.8, 3.1 Hz, 1H). Mass spectrometry analysis (ESI/MS) showed the molecular ion peak m/z 170 [M+1]+.
References
[1] Patent: WO2009/21696, 2009, A1. Location in patent: Page/Page column 65-66
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 24, p. 5923 - 5936
[3] Chemistry of Heterocyclic Compounds, 2006, vol. 42, # 1, p. 64 - 69
[4] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 2, p. 415 - 420
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8332 - 8338
2-Amino-5-fluorobenzoic acid methyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-5-fluorobenzoic acid methyl ester manufacturers
- Product
- 2-Amino-5-fluorobenzoic acid methyl ester 319-24-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 2-Amino-5-fluorobenzoic acid methyl ester 319-24-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23