ChemicalBook > CAS DataBase List > 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

Product Name: 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
CAS No.: 1015433-96-1
Chemical Name: 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
Synonyms: METHYL 4,5-DIFLUORO-2-NITROBENZOATE;methyl 3,4-difluoro-6-nitro benzoate;4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER;Benzoic acid, 4,5-difluoro-2-nitro-, methyl ester;4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER ISO 9001：2015 REACH
CBNumber: CB11485007
Molecular Formula: C8H5F2NO4
Formula Weight: 217.13
MOL File: 1015433-96-1.mol

Less

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Property

Melting point:: 59-63°
Boiling point:: 288℃
Density: 1.471
Flash point:: 128℃
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid
InChI: InChI=1S/C8H5F2NO4/c1-15-8(12)4-2-5(9)6(10)3-7(4)11(13)14/h2-3H,1H3
InChIKey: JHWZADUIXGMAKM-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC(F)=C(F)C=C1[N+]([O-])=O

Less

Safety

HS Code: 2916399090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: M303773
Product name: Methyl4,5-Difluoro-2-nitrobenzoate
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 211000
Product name: Methyl4,5-difluoro-2-nitrobenzoate
Purity: 95%
Packaging: 100mg
Price: $10
Updated: 2021/12/16

Apolloscientific

Product number: PC53622
Product name: Methyl4,5-difluoro-2-nitro-benzoate
Purity: 95%
Packaging: 5g
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: X4304
Product name: 4,5-Difluoro-2-nitrobenzoicacidmethylester
Packaging: 25g
Price: $249
Updated: 2021/12/16

Apolloscientific

Product number: PC53622
Product name: Methyl4,5-difluoro-2-nitro-benzoate
Purity: 95%
Packaging: 25g
Price: $479
Updated: 2021/12/16

Less

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4,5-difluoro-2-nitrobenzoate is mainly used as an intermediate in organic synthesis.

Synthesis

67-56-1

20372-63-8

1015433-96-1

Step 2 (Ib): to a solution of anhydrous methanol (MeOH, 1.0 L) of 4,5-difluoro-2-nitrobenzoic acid (Ia, 40.0 g, 196.947 mmol) was slowly added concentrated sulfuric acid (H2SO4, 60.0 mL), and the reaction mixture immediately became clear. The reaction system was heated to reflux with continuous stirring for 2 days. After completion of the reaction, methanol was removed by rotary evaporator under reduced pressure. The residue was liquefied with ethyl acetate (EtOAc) and water and the organic phase was collected. The organic phase was sequentially washed with saturated brine and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the filtrate was treated with anhydrous sodium sulfate (Na2SO4), filtered again, and the filtrate was concentrated to give methyl 4,5-difluoro-2-nitrobenzoate as a light yellow solid with a yield of 39.71 g and 93% yield.

References

[1] Patent: WO2008/36843, 2008, A2. Location in patent: Page/Page column 33

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER Suppliers

China 70 Germany 1 India 1 United Kingdom 2 United States 6 Global 80

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Xinyanhe Pharmatech Co.,Ltd

Tel: 0519-85252752 15366845260
Fax: 86-0519-85683352
Email: taihuaren@vip.163.com
Country: China
ProdList: 1124
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9756
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9717
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai SPAR pharmaceutical technology co., LTD

Tel: 021-000000 13917643586;
Email: admin@jingshipharmatech.com
Country: China
ProdList: 9855
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Shanghai TenSus Biotechnology Co., Ltd.

Tel: 021-50895067 18616507272
Fax: 021-50895067
Email: tensus@163.com
Country: China
ProdList: 8073
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10000
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Nanjing Puxin Pharmaceutical Technology Co., Ltd

Tel: 17366295326
Fax: QQ360829978
Email: puxinpharma_2017@126.com
Country: China
ProdList: 2444
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 15870833005
Email: 2232044025@qq.com
Country: China
ProdList: 8206
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Zhengzhou Hong Sheng Pharmaceutical Technology Co. Ltd.

Tel: 0371-55695890 15637198702
Email: 1677336983@qq.com
Country: China
ProdList: 13191
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: marketing@pharmablock.com
Country: China
ProdList: 9126
Advantage: 58

Changzhou Yanji Biotechnology Co., Ltd.

Tel: 0519-83556355 18015005120
Fax: -
Email: shikewei397@163.com
Country: China
ProdList: 3734
Advantage: 55

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-81145305 17791533577
Email: 1021@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 19355912709
Email: 690231469@qq.com
Country: China
ProdList: 7593
Advantage: 58

Nanjing Wanpu Pharmaceutical Technology Co.,Ltd

Tel: 13814527050
Email: 3773605130@qq.com
Country: China
ProdList: 361
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 14580
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29847
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Less

View Lastest Price from 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER manufacturers

Henan Fengda Chemical Co., Ltd

Product: Methyl 4,5-difluoro-2-nitrobenzoate 1015433-96-1
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-13

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 4,5-Difluoro-2-nitrobenzoate 1015433-96-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%+
Supply Ability: 100 tons
Release date: 2020-01-13

Career Henan Chemical Co

Product: 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER 1015433-96-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

1015433-96-1, 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTERRelated Search:

4,5-dichloro-2-nitrobenzaldehyde Dimethyl carbonate 4,5-DIFLUORO-2-NITROBENZOIC ACID ETHYL ESTER Methyl 4-fluoro-2-nitrobenzoate 4,5-Difluoro-2-nitrobenzoic acid 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER 2-Amino-5-fluorobenzoic acid methyl ester Methyl 2-amino-4,5-difluorobenzoate 5-Fluoro-2-nitrobenzoic acid 4-Fluoro-2-nitrobenzoic acid 4-FLUORO-2-NITRO-BENZALDEHYDE 2-Amino-4,5-difluorobenzoic acid 4,5-DIFLUORO-2-NITROTOLUENE 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER 5-Fluoro-2-nitrobenzadehyde 4-FLUORO-2-NITROBENZYL ALCOHOL

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

METHYL 4,5-DIFLUORO-2-NITROBENZOATE

methyl 3,4-difluoro-6-nitro benzoate

Benzoic acid, 4,5-difluoro-2-nitro-, methyl ester

4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER ISO 9001：2015 REACH

1015433-96-1

Fluorine series

Aromatic Esters