ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid

Product Name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
CAS No.: 106809-14-7
Chemical Name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Synonyms: CAS:106809-14-7;TIMTEC-BB SBB003130;2,4-Dichloro-3-nitro-5-fluorob;2,4-Dichloro-3-hitro-5-fluorobenzoicacid;2,4-Dichloro-5-Flouro-3-Nitrobenzoic Acid;2,4-dichloro-5-fluoro-3-cyanobenzoic acid;2,4-DICHLORO-5-FLUORO-3-NITROBENZOIC ACID;5-Fluoro-2,4-dichloro-3-nitrobenzoic acid;2,4-difluoro-5-fluoro-3-nitro benzoic acid;2,4-DICHLORO-3-NITRO-5-FLUORO BENZOIC ACID
CBNumber: CB8238463
Molecular Formula: C7H2Cl2FNO4
Formula Weight: 254
MOL File: 106809-14-7.mol

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2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Property

Melting point:: 193-197 °C (lit.)
Boiling point:: 390.4±42.0 °C(Predicted)
Density: 1.7139 (estimate)
storage temp.: 2-8°C
form: solid
pka: 1.51±0.24(Predicted)
color: White to off-white
CAS DataBase Reference: 106809-14-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 553867
Product name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Purity: 97%
Packaging: 5g
Price: $25.6
Updated: 2023/01/07

Sigma-Aldrich

Product number: 553867
Product name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Purity: 97%
Packaging: 25g
Price: $40.5
Updated: 2023/01/07

TRC

Product number: D438725
Product name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Packaging: 25g
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-W016760
Product name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Packaging: 100g
Price: $136
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD67947
Product name: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
Packaging: 100g
Price: $165
Updated: 2021/12/16

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2,4-Dichloro-5-fluoro-3-nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid may be used to synthesize:

ethyl 3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acrylate
7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
ethyl-3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate
substituted 4(1H)-oxoquinoline-3-carboxylic acid

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 927, 1988 DOI: 10.1002/jhet.5570250343

General Description

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid can be prepared from 2,4-dichloro-5-fluorobenzoic acid.

Synthesis

704-10-9

106809-14-7

General procedure for the synthesis of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid from 2',4'-dichloro-5'-fluoroacetophenone: 55 g (0.55 mol) of concentrated sulfuric acid was added to a 250 mL three-necked flask with a stirrer and reflux condenser tube. Under stirring (stirring speed of 400 r/min), 19.29 g (0.3 mol) fuming nitric acid was slowly added to the three-necked flask. Subsequently, the reaction mixture was warmed up to 103 °C and 10.46 g (0.05 mol) of pre-melted 2,4-dichloro-5-fluoroacetophenone was slowly added dropwise at this temperature, controlling the dropwise temperature to be between 103 and 110 °C. After the dropwise addition was completed, the reaction temperature was maintained at 106 °C to continue the reaction for 3 hours. After completion of the reaction, the mixture was cooled to 10 °C and separated by filtration. The filtrate was recovered and set aside, and the filter cake was washed with water. Finally, the filter cake was recrystallized with toluene to give 11.67 g of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid with 99% purity and 91% yield.

References

[1] Patent: CN103922942, 2016, B. Location in patent: Paragraph 0026; 0027
[2] Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 927 - 930

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Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid 106809-14-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

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CAS:106809-14-7

106809-14-7

C7H2Cl2FNO4

C7HCl2FNO4

C6HCl2FNO2COOH

Organic Building Blocks

Building Blocks

Carboxylic Acids

Carbonyl Compounds

Benzoic acid

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts