4-Chloro-3-fluorobenzoic acid
- Product Name
- 4-Chloro-3-fluorobenzoic acid
- CAS No.
- 403-17-8
- Chemical Name
- 4-Chloro-3-fluorobenzoic acid
- Synonyms
- BUTTPARK 19\01-69;RARECHEM AL BO 1770;4-Chloro-3-Fluorobenzoic;4-CHLORO-3-FLUOROBENZOIC ACID;3-FLUORO-4-CHLOROBENZOIC ACID;4-Chloro-3-fluorobenzoicacid97%;Benzoic acid, 4-chloro-3-fluoro-;4-Chloro-3-fluorobenzoic Acid >4-Chloro-3-fluorobenzoic acid 97%
- CBNumber
- CB1481923
- Molecular Formula
- C7H4ClFO2
- Formula Weight
- 174.56
- MOL File
- 403-17-8.mol
4-Chloro-3-fluorobenzoic acid Property
- Melting point:
- 190-192°C
- Boiling point:
- 290.9±20.0 °C(Predicted)
- Density
- 1.477±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 3.63±0.10(Predicted)
- color
- Off-White to Pale yellow
- InChI
- InChI=1S/C7H4ClFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)
- InChIKey
- QPIBHIXKUQKNFP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(Cl)C(F)=C1
- CAS DataBase Reference
- 403-17-8(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 4-chloro-3-fluoro- (403-17-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37-26
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2891
- Product name
- 4-Chloro-3-fluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- C427700
- Product name
- 4-Chloro-3-fluorobenzoic Acid
- Packaging
- 10g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C427700
- Product name
- 4-Chloro-3-fluorobenzoic Acid
- Packaging
- 25g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 002344
- Product name
- 4-Chloro-3-fluorobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- PC1861H
- Product name
- 4-Chloro-3-fluorobenzoic Acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
4-Chloro-3-fluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
4-Chloro-3-fluorobenzoic Acid is a very useful precursor. It is a reagent used to synthesize 6-Hydroxy Albaconazole (H761395) which is a metabolite of Albaconazole (A511450), an antifungal agent as neuroprotectant.
Synthesis
5527-94-6
64-19-7
403-17-8
The general procedure for the synthesis of 4-chloro-3-fluorobenzoic acid from 3-fluoro-4-chlorotoluene and glacial acetic acid was as follows: 99 g of glacial acetic acid, 2.7 g of manganese acetate, and 105 g of 98% sulfuric acid were added to a 20 L autoclave, followed by the addition of 870 g (5.96 mol) of 3-fluoro-4-chlorotoluene of 99% purity. The mixture was stirred and cooled to 15°C, then 215 g of ozone was slowly added (in 10 additions). After completion of the photodissociation process of nitrogen with ozone, the reaction was carried out. Subsequently, the temperature and pressure were adjusted to recover glacial acetic acid, and the layers were separated to ultimately recover 988 g of product to give 4-chloro-3-fluorobenzoic acid with 98.2% purity in about 94.2% yield.
References
[1] Patent: CN107488098, 2017, A. Location in patent: Paragraph 0031
4-Chloro-3-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-fluorobenzoic acid manufacturers
- Product
- 4-Chloro-3-fluorobenzoic acid 403-17-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-03
- Product
- 4-Chloro-3-fluorobenzoic acid 403-17-8
- Price
- US $135.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- 4-Chloro-3-fluorobenzoic acid 403-17-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-25