2-Chloro-3-nitropyridine
- Product Name
- 2-Chloro-3-nitropyridine
- CAS No.
- 5470-18-8
- Chemical Name
- 2-Chloro-3-nitropyridine
- Synonyms
- AURORA KA-2997;oro-3-nitropyridine;Chloro-3-nitropyrid;2-Chloro-3-nitropyri;2-Chrolo-3-nitropyridin;2-chloro-3-nitro-pyridin;3-Nitro-2-chloropyridine;2-Chrolo-3-nitropyridine;2-CHLORO-3-NITROPYRIDINE;Pyridine, 2-chloro-3-nitro-
- CBNumber
- CB9206306
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 5470-18-8.mol
2-Chloro-3-nitropyridine Property
- Melting point:
- 100-103 °C (lit.)
- Boiling point:
- 260.3±20.0 °C(Predicted)
- Density
- 1.6616 (rough estimate)
- refractive index
- 1.454-1.456
- Flash point:
- 185°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Insoluble in water
- pka
- -2.60±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow
- BRN
- 124482
- InChI
- InChI=1S/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
- InChIKey
- UUOLETYDNTVQDY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 5470-18-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chloro-3-nitropyridine(5470-18-8)
- EPA Substance Registry System
- Pyridine, 2-chloro-3-nitro- (5470-18-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/22-36/37/38-22
- Safety Statements
- 22-24/25-37/39-26-36
- RIDADR
- UN 2811
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C61607
- Product name
- 2-Chloro-3-nitropyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $42.4
- Updated
- 2025/07/31
- Product number
- C61607
- Product name
- 2-Chloro-3-nitropyridine
- Purity
- 99%
- Packaging
- 25g
- Price
- $68.38
- Updated
- 2025/07/31
- Product number
- C1008
- Product name
- 2-Chloro-3-nitropyridine
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- C1008
- Product name
- 2-Chloro-3-nitropyridine
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $74
- Updated
- 2025/07/31
- Product number
- C597058
- Product name
- 2-Chloro-3-nitropyridine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
2-Chloro-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
2-Chloro-3-nitropyridine is often used as a pharmaceutical intermediate.
Reactions
2-Chloro-3-nitropyridine is a nucleophilic compound that reacts with amines to form substituted amines.
Synthesis
59290-85-6
5470-18-8
General procedure for the synthesis of 2-chloro-3-nitropyridine from 3-nitropyridine-2-carboxylic acid: accurately weigh 3-nitropyridine-2-carboxylic acid (50.4 mg, 0.3 mmol), sodium carbonate (64.0 mg, 0.6 mmol), sodium chloride (17.6 mg, 0.3 mmol) and tert-butyl hypochlorite (32 μL, 0.3 mmol) in a 25 mL Schlenk reaction flask. Subsequently, dichloromethane (3 mL) was added as a solvent and the reaction mixture was placed in an oil bath at 25 °C for 20 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-nitropyridine in 58% yield.
Purification Methods
It forms needles from H2O. Purify it by continuous sublimation over a period of 2 weeks at 50-60o/0.1mm [Barlin J Chem Soc 2150 1964]. The N-oxide has m 100o(from CH2Cl2/Et2O). [Taylor & Driscoll J Org Chem 25 1716 1960, Ochiai & Kaneko Chem Pharm Bull Jpn 8 28 1960, Beilstein 20/5 V 451.]
References
[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0060-0062
2-Chloro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-nitropyridine manufacturers
- Product
- 2-Chloro-3-nitropyridine 5470-18-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Chloro-3-nitropyridine 5470-18-8
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98%min GC
- Supply Ability
- 100KGS
- Release date
- 2021-07-23
- Product
- 2-Chloro-3-nitropyridine 5470-18-8
- Price
- US $6.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-24