2-Chloro-3-methylpyridine
- Product Name
- 2-Chloro-3-methylpyridine
- CAS No.
- 18368-76-8
- Chemical Name
- 2-Chloro-3-methylpyridine
- Synonyms
- 2-CHLORO-3-METHYLPYRIDINE;2-CHLORO-3-PICOLINE;2-Chloro-3-Pilcoline;2-CHLORO-3-METHYLP...;2-Chloro-3-picoline,98%;2-Choro-3-methypyridine;2-Chlor-3-methylpyridin;2-Chloro-3-mehyl pyridine;2-CHLORO-3-METHYLPYRRIDINE;Pyridine, 2-chloro-3-methyl-
- CBNumber
- CB1391806
- Molecular Formula
- C6H6ClN
- Formula Weight
- 127.57
- MOL File
- 18368-76-8.mol
2-Chloro-3-methylpyridine Property
- Melting point:
- 193 °C
- Boiling point:
- 192-193 °C/751 mmHg (lit.)
- Density
- 1.17 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.533(lit.)
- Flash point:
- 175 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 0.75±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- Specific Gravity
- 1.170
- BRN
- 107895
- InChI
- InChI=1S/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
- InChIKey
- RKVUCIFREKHYTL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C
- CAS DataBase Reference
- 18368-76-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- RIDADR
- 2810
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 518948
- Product name
- 2-Chloro-3-methylpyridine
- Purity
- 97%
- Packaging
- 5ml
- Price
- $59.4
- Updated
- 2022/05/15
- Product number
- 518948
- Product name
- 2-Chloro-3-methylpyridine
- Purity
- 97%
- Packaging
- 25ml
- Price
- $192
- Updated
- 2022/05/15
- Product number
- C1885
- Product name
- 2-Chloro-3-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- C1885
- Product name
- 2-Chloro-3-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- C428772
- Product name
- 2-Chloro-3-methylpyridine
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
2-Chloro-3-methylpyridine Chemical Properties,Usage,Production
Description
2-Chloro-3-methylpyridine is an intermediate for many medicines and pesticides, such as fluazifop, nicosulfuron, and fluazifop. Moreover, with the gradual promotion of these new high-efficiency and low-toxic heterocyclic pesticides, 2-chloro-3-methylpyridine is increasing. The industrial method for preparing 2-chloro-3-methylpyridine is to obtain it by site-specific chlorination of 3-methylpyridine. First, 3-methylpyridine is epoxidized and then chlorinated. The main chlorinated 3-methylpyridine is a mixture of 2-chloro-3-methylpyridine and 2-chloro-5-methylpyridine, of which 2-chloro-3-methylpyridine accounts for 20% (mass).
Chemical Properties
colorless to light yellow liquid
Uses
2-Chloro-3-methylpyridine is an active ingredient and a major constituent of imidaclopide, a systemic insecticide that acts as insect neurotoxin and belongs to a class of chemical called the neonicotinoids.
Application
2-Chloro-3-methylpyridine can be used as an intermediate for Lumacaftor. Lumacaftor is a drug used to treat certain types of cystic fibrosis, particularly by assisting in the transport of CFTR protein to the cell membrane surface, thereby addressing respiratory issues associated with the disease.
Synthesis
4021-07-2
18368-76-8
General procedure for the synthesis of 2-chloro-3-methylpyridine from 3-methyl-2-pyridinecarboxylic acid: 3-methylpyridine-2-carboxylic acid (56.7 mg, 0.3 mmol), sodium hydroxide (16.0 mg, 0.15 mmol), tetrabutylammonium chloride (TBAC, 26.3 mg, 0.45 mmol) and di-tert-butyl peroxide (DTBP. 165 μL, 0.9 mmol) were placed in a 25 mL Schlenk reaction flask. Subsequently, 1 mL of acetonitrile (CH3CN) was added as a solvent and the reaction mixture was placed in an oil bath at 50 °C for 20 h. The reaction was carried out at a pressure of 1.5 mL. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-methylpyridine in 70% yield.
References
[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0048-0050
2-Chloro-3-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-methylpyridine Suppliers
- Tel
- 0370-6999054 17550096163
- 3189729795@qq.com
- Country
- China
- ProdList
- 7172
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 0418-6530555 2855550
- Fax
- +86-418-6502885
- Country
- China
- ProdList
- 338
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
View Lastest Price from 2-Chloro-3-methylpyridine manufacturers
- Product
- 2-Chloro-3-methylpyridine 18368-76-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Chloro-3-picoline 18368-76-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 2-Chloro-3-methylpyridine 18368-76-8
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-04