2,6-Dichloro-4-methylnicotinonitrile

Product Name: 2,6-Dichloro-4-methylnicotinonitrile
CAS No.: 875-35-4
Chemical Name: 2,6-Dichloro-4-methylnicotinonitrile
Synonyms: 2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE;2,6-DICHLORO-4-METHYLPYRIDINE-3-CARBONITRILE;001.01.0121;BUTTPARK 43\57-14;IFLAB-BB F0907-8363;2,6-Dichloro-4-methy;3-Cyano-2,6-dichloro-4-methyl;3-Cyano-2,6-dichloro-GAMMA-picoline;3-Cyano-2,6-Chloro-4-methylpyridine;2,6-DICHLORO-4-METHYLNICOTINONITRILE
CBNumber: CB9458969
Molecular Formula: C7H4Cl2N2
Formula Weight: 187.03
MOL File: 875-35-4.mol

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2,6-Dichloro-4-methylnicotinonitrile Property

Melting point:: 108-112 °C(lit.)
Boiling point:: 118 °C / 5mmHg
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: 0.4g/l
pka: -4.53±0.10(Predicted)
form: solid
PH: 3.5 (H2O, 20℃)(aqueous suspension)
Appearance: White to light brown Solid
InChI: InChI=1S/C7H4Cl2N2/c1-4-2-6(8)11-7(9)5(4)3-10/h2H,1H3
InChIKey: LSPMHHJCDSFAAY-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC(C)=C1C#N
CAS DataBase Reference: 875-35-4(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 20/21-25-37/38-41-43-36/37/38
Safety Statements: 26-36/37/39-45-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 643521
Product name: 2,6-Dichloro-4-methylnicotinonitrile
Purity: 97%
Packaging: 25g
Price: $244
Updated: 2025/07/31

Sigma-Aldrich

Product number: 643521
Product name: 2,6-Dichloro-4-methylnicotinonitrile
Purity: 97%
Packaging: 5g
Price: $79.8
Updated: 2023/06/20

TCI Chemical

Product number: D3346
Product name: 2,6-Dichloro-3-cyano-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: D3346
Product name: 2,6-Dichloro-3-cyano-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $56
Updated: 2025/07/31

TRC

Product number: D437080
Product name: 2,6-Dichloro-4-methylnicotinonitrile
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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2,6-Dichloro-4-methylnicotinonitrile Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder

Uses

2,6-Dichloro-4-methylnicotinonitrile is a pharmaceutical intermediate compound of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of human immunodeficiency virus (HIV).

Synthesis

5444-02-0

875-35-4

General procedure for the synthesis of 3-cyano-4-methyl-2,6-dichloropyridine from 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile: 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (28.0 g, 195.2 mmol) was dissolved in phosphorus triclosan (60.0 mL). The reaction mixture was transferred to a pressure tube, sealed and heated to 180 °C for 6 hours. Upon completion of the reaction, it was cooled to room temperature and excess phosphorous trichloride was removed by distillation under reduced pressure. Crushed ice was slowly added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford the target product 3-cyano-4-methyl-2,6-dichloropyridine in 92% yield without further purification.

References

[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 979 - 984
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0174; 0175
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0175; 0176
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0079; 0080
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0177; 0178; 0179

2,6-Dichloro-4-methylnicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-4-methylnicotinonitrile Suppliers

Americas 1 Belgium 1 Canada 2 China 251 Europe 3 France 1 Germany 6 India 9 Japan 2 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 16 United States 36 Global 333

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View Lastest Price from 2,6-Dichloro-4-methylnicotinonitrile manufacturers

Hangzhou Verychem Science And Technology Co.Ltd

Product: 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price: US $0.00-0.00/kg
Min. Order: 25kg
Purity: 99%min
Supply Ability: 10 tons
Release date: 2025-08-12

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-11-24

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-14

875-35-4, 2,6-Dichloro-4-methylnicotinonitrileRelated Search:

Basic Violet 1 2-Chloro-5-chloromethylpyridine 2,6-Dichloropyridine Methyl acrylate Methyl salicylate Methanol Tribenuron methyl 4-Methylpyridine 3-Cyanopyridine 2,6-Lutidine Clopyralid 3-Cyano-4-methylpyridine Methylparaben Kresoxim-methyl Methyl 2-Chloro-3-picoline 2-Chloro-5-methylpyridine 2-Chloro-4-picoline

BUTTPARK 43\57-14

IFLAB-BB F0907-8363

3-PYRIDINECARBONITRILE, 2,6-DICHLORO-4-METHYL-

3-CYANO-2,6-DICHLORO-4-METHYLPYRIDINE

3-Cyano-4-methyl-2,6-dichloropyridine

2,6-DICHLORO-4-METHYL-3-CYANOPYRIDINE

2,6-DICHLORO-4-METHYLNICOTINONITRILE

2,6-DICHLORO-4-METHYLPYRIDINE-3-CARBONITRILE

2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE

3-Cyano-2,6-Dichloro-4-Methylpyridine 2,6-Dichloro-3-Cyano-4-Methylpyridine

3-Cyano-2,6-dichloro-4-methyl

2,6-DICHLORO-4-METHYL-3-PYRIDINECARBONITRILE

3-Cyano-2,6-dichloro-GAMMA-picoline

2,6-DICHLORO-4-METHYLNICOTINONITRILE (3-CYANO-2,6-DICHLORO-4-METHYLPYRIDINE)

3-Cyano-2,6-Chloro-4-methylpyridine

2,6-Dichloro-4-methylnicotinonitrile (3-Cyano-2,6-dichloro-4-met

2,6-Dichloro-4-methylnicotinonitrile ,99%

2,6-Dichloro-4-methy

2,6-dichloro-3-cyano-4-Methylpynidine

2,6-Dichloro-4-methylnicotinonitrile 97%

2,6-Dichloro-4-methylpyridine-3-carbonitrile, 3-Cyano-2,6-dichloro-4-methylpyridine

3-cyano -4-Methyl -2,6-two chlorine pyridine

001.01.0121

2,6-Dichloro-3-cyano-4-methylpyridine&gt

2,6-Dichloro-4-methylnicotinonitrile ISO 9001：2015 REACH

TIANFU-CHEM CAS NO.875-35-4 2,6-Dichloro-4-methylnicotinonitrile

2,6-Dichloro-4-methylnicotinonitrile?New

2,6 Dichloro 3 Cyano 4 Methyl Pyridene

3-CYANO 2 6 DICHLORO METHYL PYRIDINE

2,6-Dichloro-4-methyinicotinonitrile

2,6-Dichloro-4-methylpyridin-3-carbonitrile

875-35-4

85-35-4

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Building Blocks

C7 to C18

C7 to C8

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridine series

C7 and C8Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

API intermediates

Pyridines

Chloropyridines

Halopyridines

bc0001