3-Cyano-4-methylpyridine

Product Name: 3-Cyano-4-methylpyridine
CAS No.: 5444-01-9
Chemical Name: 3-Cyano-4-methylpyridine
Synonyms: NSC 19882;3-Cyano-4-methyL;4-Methylnicotinyl;3-Cyano-4-picoline;4-Methylnicotinotrile;4-METHYLNICOTINONITRILE;3-CYANO-4-METHYLPYRIDINE;3-Cyano-4-methylpyridine >3-Cyano-4-methylpyridine ,98%;4-Methylpyridine-3-carbonitrile
CBNumber: CB1333509
Molecular Formula: C7H6N2
Formula Weight: 118.14
MOL File: 5444-01-9.mol

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3-Cyano-4-methylpyridine Property

Melting point:: 41-44°C
Boiling point:: 108-111°C 20mm
Density: 1.08±0.1 g/cm3(Predicted)
Flash point:: 108-111°C/20mm
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 2.45±0.18(Predicted)
color: White to Orange to Green
BRN: 112016
InChI: InChI=1S/C7H6N2/c1-6-2-3-9-5-7(6)4-8/h2-3,5H,1H3
InChIKey: XLAPHZHNODDMDD-UHFFFAOYSA-N
SMILES: C1=NC=CC(C)=C1C#N
CAS DataBase Reference: 5444-01-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-36/38-22
Safety Statements: 22-36/37/39-36-26-36/37
RIDADR: 3439
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2608
Product name: 3-Cyano-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: C2608
Product name: 3-Cyano-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $187
Updated: 2025/07/31

TRC

Product number: C987495
Product name: 3-Cyano-4-methylpyridine
Packaging: 500mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0023432
Product name: 3-CYANO-4-METHYLPYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $600.79
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0023432
Product name: 3-CYANO-4-METHYLPYRIDINE
Purity: 95.00%
Packaging: 5G
Price: $832.25
Updated: 2021/12/16

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3-Cyano-4-methylpyridine Chemical Properties,Usage,Production

Uses

3-Cyano-4-methylpyridine, is an intermediate for the synthesis of various pharmaceutical compounds, including inhibitors and anticancer agents. It can be used for the preparation of a series of azaindenoisoquinoline topoisomerase I I inhibitors and potential anticancer agents.

Synthesis

875-35-4

5444-01-9

General procedure for the synthesis of 3-cyano-4-methylpyridine (112) from 3-cyano-4-methyl-2,6-dichloropyridine (Ref. J. Org. Chem. 1960, 25, 560-564): palladium dichloride (50 mg, 0.3 mmol) was added to a degassed 3-cyano-4-methyl-2,6-dichloropyridine (5.0 g, 27 mmol) and sodium acetate (4.5 g, 55 mmol) in a methanol (100 mL) solution. The reaction mixture was stirred under hydrogen (1 atm) atmosphere for 14 hours at room temperature. After completion of the reaction, the precipitate was filtered and washed with methanol (3 x 20 mL). The filtrates were combined, the solvent was removed by evaporation under reduced pressure and chloroform (50 mL) was added to the residue. The chloroform solution was filtered through a thin silica gel pad and the silica gel pad was washed with additional chloroform. The filtrate was evaporated to dryness to afford 3-cyano-4-methylpyridine (112) (2.9 g, 93% yield) as a yellow oil. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.77 (s, 1H), 8.63 (s, J = 6.0 Hz, 1H), 7.3 (d, J = 6.0 Hz, 1H), 2.56 (s, 3H). The resulting 3-cyano-4-methylpyridine (112) can be used in subsequent reactions without further purification.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0146
[3] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 36
[4] Letters in Organic Chemistry, 2016, vol. 13, # 6, p. 450 - 452

3-Cyano-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyano-4-methylpyridine Suppliers

Americas 1 Canada 1 China 227 Europe 2 Germany 2 India 5 Japan 1 The Netherlands 1 Ukraine 1 United Kingdom 12 United States 28 Global 281

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View Lastest Price from 3-Cyano-4-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Cyano-4-methylpyridine 5444-01-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Henan Fengda Chemical Co., Ltd

Product: 3-Cyano-4-methylpyridine 5444-01-9
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 3-Cyano-4-methylpyridine 5444-01-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-14

5444-01-9, 3-Cyano-4-methylpyridineRelated Search:

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3-CYANO-4-METHYLPYRIDINE

4-METHYLNICOTINONITRILE

3-Cyano-4-picoline

4-Methylnicotinotrile

4-Methylpyridine-3-carbonitrile

3-Pyridinecarbonitrile, 4-methyl-

3-Cyano-4-methylpyridine ,98%

4-Methyl-3-pyridinecarbonitrile 4-Methylnicotinonitrile

NSC 19882

3-Cyano-4-methylpyridine &gt

3-Cyano-4-methyL

3-Cyano-4-methylpyridine ISO 9001：2015 REACH

4-Methylnicotinyl

5444-01-9

5444-1-9

1294-42-9

544-01-9

1294665

5444-10-9

5444-19-1

Heterocycle-Pyridine series

Pyridines

Pyridine

Pyridines derivates