ChemicalBook > CAS DataBase List > 2,6-Dichloro-4-methylnicotinonitrile

2,6-Dichloro-4-methylnicotinonitrile

Product Name
2,6-Dichloro-4-methylnicotinonitrile
CAS No.
875-35-4
Chemical Name
2,6-Dichloro-4-methylnicotinonitrile
Synonyms
2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE;2,6-DICHLORO-4-METHYLPYRIDINE-3-CARBONITRILE;001.01.0121;BUTTPARK 43\57-14;IFLAB-BB F0907-8363;2,6-Dichloro-4-methy;3-Cyano-2,6-dichloro-4-methyl;3-Cyano-2,6-dichloro-GAMMA-picoline;3-Cyano-2,6-Chloro-4-methylpyridine;2,6-DICHLORO-4-METHYLNICOTINONITRILE
CBNumber
CB9458969
Molecular Formula
C7H4Cl2N2
Formula Weight
187.03
MOL File
875-35-4.mol
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2,6-Dichloro-4-methylnicotinonitrile Property

Melting point:
108-112 °C(lit.)
Boiling point:
118 °C / 5mmHg
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
0.4g/l
pka
-4.53±0.10(Predicted)
form 
solid
PH
3.5 (H2O, 20℃)(aqueous suspension)
Appearance
White to light brown Solid
InChI
InChI=1S/C7H4Cl2N2/c1-4-2-6(8)11-7(9)5(4)3-10/h2H,1H3
InChIKey
LSPMHHJCDSFAAY-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C)=C1C#N
CAS DataBase Reference
875-35-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
20/21-25-37/38-41-43-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
643521
Product name
2,6-Dichloro-4-methylnicotinonitrile
Purity
97%
Packaging
25g
Price
$244
Updated
2025/07/31
Sigma-Aldrich
Product number
643521
Product name
2,6-Dichloro-4-methylnicotinonitrile
Purity
97%
Packaging
5g
Price
$79.8
Updated
2023/06/20
TCI Chemical
Product number
D3346
Product name
2,6-Dichloro-3-cyano-4-methylpyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
D3346
Product name
2,6-Dichloro-3-cyano-4-methylpyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$56
Updated
2025/07/31
TRC
Product number
D437080
Product name
2,6-Dichloro-4-methylnicotinonitrile
Packaging
500mg
Price
$45
Updated
2021/12/16
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2,6-Dichloro-4-methylnicotinonitrile Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder

Uses

2,6-Dichloro-4-methylnicotinonitrile is a pharmaceutical intermediate compound of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of human immunodeficiency virus (HIV).

Synthesis

5444-02-0

875-35-4

General procedure for the synthesis of 3-cyano-4-methyl-2,6-dichloropyridine from 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile: 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (28.0 g, 195.2 mmol) was dissolved in phosphorus triclosan (60.0 mL). The reaction mixture was transferred to a pressure tube, sealed and heated to 180 °C for 6 hours. Upon completion of the reaction, it was cooled to room temperature and excess phosphorous trichloride was removed by distillation under reduced pressure. Crushed ice was slowly added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford the target product 3-cyano-4-methyl-2,6-dichloropyridine in 92% yield without further purification.

References

[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 979 - 984
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0174; 0175
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0175; 0176
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0079; 0080
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0177; 0178; 0179

2,6-Dichloro-4-methylnicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-4-methylnicotinonitrile Suppliers

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View Lastest Price from 2,6-Dichloro-4-methylnicotinonitrile manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
99%min
Supply Ability
10 tons
Release date
2025-08-12
Shaanxi Dideu Medichem Co. Ltd
Product
2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-11-24
Hebei Zhanyao Biotechnology Co. Ltd
Product
2,6-Dichloro-4-methylnicotinonitrile 875-35-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14

875-35-4, 2,6-Dichloro-4-methylnicotinonitrileRelated Search:

Basic Violet 1 2-Chloro-5-chloromethylpyridine 2,6-Dichloropyridine Methyl acrylate Methyl salicylate Methanol Tribenuron methyl 4-Methylpyridine 3-Cyanopyridine 2,6-Lutidine Clopyralid 3-Cyano-4-methylpyridine Methylparaben Kresoxim-methyl Methyl 2-Chloro-3-picoline 2-Chloro-5-methylpyridine 2-Chloro-4-picoline

  • BUTTPARK 43\57-14
  • IFLAB-BB F0907-8363
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  • 3-CYANO-2,6-DICHLORO-4-METHYLPYRIDINE
  • 3-Cyano-4-methyl-2,6-dichloropyridine
  • 2,6-DICHLORO-4-METHYL-3-CYANOPYRIDINE
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  • 3-Cyano-2,6-dichloro-4-methyl
  • 2,6-DICHLORO-4-METHYL-3-PYRIDINECARBONITRILE
  • 3-Cyano-2,6-dichloro-GAMMA-picoline
  • 2,6-DICHLORO-4-METHYLNICOTINONITRILE (3-CYANO-2,6-DICHLORO-4-METHYLPYRIDINE)
  • 3-Cyano-2,6-Chloro-4-methylpyridine
  • 2,6-Dichloro-4-methylnicotinonitrile (3-Cyano-2,6-dichloro-4-met
  • 2,6-Dichloro-4-methylnicotinonitrile ,99%
  • 2,6-Dichloro-4-methy
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  • 2,6-Dichloro-4-methylnicotinonitrile 97%
  • 2,6-Dichloro-4-methylpyridine-3-carbonitrile, 3-Cyano-2,6-dichloro-4-methylpyridine
  • 3-cyano -4-Methyl -2,6-two chlorine pyridine
  • 001.01.0121
  • 2,6-Dichloro-3-cyano-4-methylpyridine&gt
  • 2,6-Dichloro-4-methylnicotinonitrile ISO 9001：2015 REACH
  • TIANFU-CHEM CAS NO.875-35-4 2,6-Dichloro-4-methylnicotinonitrile
  • 2,6-Dichloro-4-methylnicotinonitrile?New
  • 2,6 Dichloro 3 Cyano 4 Methyl Pyridene
  • 3-CYANO 2 6 DICHLORO METHYL PYRIDINE
  • 2,6-Dichloro-4-methyinicotinonitrile
  • 2,6-Dichloro-4-methylpyridin-3-carbonitrile
  • 875-35-4
  • 85-35-4
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Building Blocks
  • C7 to C18
  • C7 to C8
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridine series
  • C7 and C8Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • API intermediates
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • bc0001