2,6-Dichloro-4-methylnicotinonitrile
- Product Name
- 2,6-Dichloro-4-methylnicotinonitrile
- CAS No.
- 875-35-4
- Chemical Name
- 2,6-Dichloro-4-methylnicotinonitrile
- Synonyms
- 2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE;2,6-DICHLORO-4-METHYLPYRIDINE-3-CARBONITRILE;001.01.0121;BUTTPARK 43\57-14;IFLAB-BB F0907-8363;2,6-Dichloro-4-methy;3-Cyano-2,6-dichloro-4-methyl;3-Cyano-2,6-dichloro-GAMMA-picoline;3-Cyano-2,6-Chloro-4-methylpyridine;2,6-DICHLORO-4-METHYLNICOTINONITRILE
- CBNumber
- CB9458969
- Molecular Formula
- C7H4Cl2N2
- Formula Weight
- 187.03
- MOL File
- 875-35-4.mol
2,6-Dichloro-4-methylnicotinonitrile Property
- Melting point:
- 108-112 °C(lit.)
- Boiling point:
- 118 °C / 5mmHg
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- 0.4g/l
- pka
- -4.53±0.10(Predicted)
- form
- solid
- PH
- 3.5 (H2O, 20℃)(aqueous suspension)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C7H4Cl2N2/c1-4-2-6(8)11-7(9)5(4)3-10/h2H,1H3
- InChIKey
- LSPMHHJCDSFAAY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(C)=C1C#N
- CAS DataBase Reference
- 875-35-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 20/21-25-37/38-41-43-36/37/38
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 643521
- Product name
- 2,6-Dichloro-4-methylnicotinonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $244
- Updated
- 2025/07/31
- Product number
- 643521
- Product name
- 2,6-Dichloro-4-methylnicotinonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $79.8
- Updated
- 2023/06/20
- Product number
- D3346
- Product name
- 2,6-Dichloro-3-cyano-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- D3346
- Product name
- 2,6-Dichloro-3-cyano-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- D437080
- Product name
- 2,6-Dichloro-4-methylnicotinonitrile
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
2,6-Dichloro-4-methylnicotinonitrile Chemical Properties,Usage,Production
Chemical Properties
White to light brown powder
Uses
2,6-Dichloro-4-methylnicotinonitrile is a pharmaceutical intermediate compound of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of human immunodeficiency virus (HIV).
Synthesis
5444-02-0
875-35-4
General procedure for the synthesis of 3-cyano-4-methyl-2,6-dichloropyridine from 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile: 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (28.0 g, 195.2 mmol) was dissolved in phosphorus triclosan (60.0 mL). The reaction mixture was transferred to a pressure tube, sealed and heated to 180 °C for 6 hours. Upon completion of the reaction, it was cooled to room temperature and excess phosphorous trichloride was removed by distillation under reduced pressure. Crushed ice was slowly added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford the target product 3-cyano-4-methyl-2,6-dichloropyridine in 92% yield without further purification.
References
[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 979 - 984
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0174; 0175
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0175; 0176
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0079; 0080
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0177; 0178; 0179
2,6-Dichloro-4-methylnicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dichloro-4-methylnicotinonitrile Suppliers
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- Country
- Belgium
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View Lastest Price from 2,6-Dichloro-4-methylnicotinonitrile manufacturers
- Product
- 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 25kg
- Purity
- 99%min
- Supply Ability
- 10 tons
- Release date
- 2025-08-12
- Product
- 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-11-24
- Product
- 2,6-Dichloro-4-methylnicotinonitrile 875-35-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14