2-Chloronicotinamide
- Product Name
- 2-Chloronicotinamide
- CAS No.
- 10366-35-5
- Chemical Name
- 2-Chloronicotinamide
- Synonyms
- 2-Chloronicotimide;TIMTEC-BB SBB004012;RARECHEM AH CK 0070;2-CHLORONICOTINAMIDE;2-CHLORONICOTINALDEHYDE;Nicotinamide, 2-chloro-;2-Chloronicotinamide 98%;2-Chloronicotinamide >2-CHLORONICOTINAMIDE CNAM;2-Chloronicotinamide, 98+%
- CBNumber
- CB9449716
- Molecular Formula
- C6H5ClN2O
- Formula Weight
- 156.57
- MOL File
- 10366-35-5.mol
2-Chloronicotinamide Property
- Melting point:
- 164-167 °C(lit.)
- Boiling point:
- 313.7±27.0 °C(Predicted)
- Density
- 1.4411 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.19±0.50(Predicted)
- form
- Fine Crystalline Powder
- color
- Beige
- BRN
- 119026
- InChI
- InChI=1S/C6H5ClN2O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,8,10)
- InChIKey
- ZQZAHPFFZWEUCL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(N)=O
- CAS DataBase Reference
- 10366-35-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C1404
- Product name
- 2-Chloronicotinamide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- C1404
- Product name
- 2-Chloronicotinamide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $137
- Updated
- 2025/07/31
- Product number
- C380503
- Product name
- 2-Chloronicotinamide
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C380503
- Product name
- 2-Chloronicotinamide
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 052746
- Product name
- 2-Chloronicotinamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
2-Chloronicotinamide Chemical Properties,Usage,Production
Chemical Properties
BEIGE FINE CRYSTALLINE POWDER
Synthesis
6602-54-6
10366-35-5
General procedure for the synthesis of 2-chloronicotinamide from 2-chloro-3-cyanopyridine: 400 mL of concentrated sulfuric acid was added to a 1000 mL three-necked flask, followed by the addition of 2-chloro-3-cyanopyridine (138 g, 1 mol), which was stirred until completely dissolved. The reaction system was warmed up to 90 °C and the reaction was maintained at this temperature with stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into a mixture containing 1000 mL of ammonia and 1 kg of ice and stirring was continued for 1 hour. The precipitated crude product was collected by filtration. The crude product was transferred to 1000 mL of ethyl acetate and stirred for 1 hour to wash and subsequently separated by filtration to give a white solid product. Finally, the white solid was dried by blowing at 50 °C to give 153 g of the intermediate 2-chloronicotinamide as a white solid in 98% yield.
References
[1] Patent: CN105367571, 2017, B. Location in patent: Paragraph 0014; 0037; 0038
[2] Tetrahedron Letters, 2012, vol. 53, # 4, p. 449 - 452
[3] Journal of Chemical Research, 2011, vol. 35, # 8, p. 480 - 483
[4] Synlett, 2018, vol. 29, # 15, p. 2061 - 2065
[5] Journal of Organic Chemistry, 1954, vol. 19, p. 1633,1636
2-Chloronicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloronicotinamide Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
View Lastest Price from 2-Chloronicotinamide manufacturers
- Product
- 2-Chloronicotinamide 10366-35-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14
- Product
- 2-Chloronicotinamide 10366-35-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22
- Product
- 2-Chloronicotinamide 10366-35-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10