5-Amino-2-methylpyridine

Product Name: 5-Amino-2-methylpyridine
CAS No.: 3430-14-6
Chemical Name: 5-Amino-2-methylpyridine
Synonyms: 6-Methylpyridin-3-amine;5-AMINO-2-PICOLINE;6-METHYL-PYRIDIN-3-YLAMINE;AURORA KA-7923;5-Aminopicoline;3-AMINO-6-PICOLINE;5-Amino-2-methylpyri;6-Methyl-Pyridin-3-yl;5-Amino-2-methypyridine;2-Methyl-5-Aminoyridine
CBNumber: CB6700252
Molecular Formula: C6H8N2
Formula Weight: 108.14
MOL File: 3430-14-6.mol

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5-Amino-2-methylpyridine Property

Melting point:: 95-99°C
Boiling point:: 238.4±20.0 °C(Predicted)
Density: 1.068±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 6.89±0.10(Predicted)
form: Powder
color: Off-white to orange to brown
InChI: InChI=1S/C6H8N2/c1-5-2-3-6(7)4-8-5/h2-4H,7H2,1H3
InChIKey: UENBBJXGCWILBM-UHFFFAOYSA-N
SMILES: C1=NC(C)=CC=C1N
LogP: 0.704
CAS DataBase Reference: 3430-14-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi,C
Risk Statements: 22-37/38-41-36/37/38-34-24/25
Safety Statements: 26-36/39-45-36/37/39-36-27-36/37
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 662704
Product name: 5-Amino-2-methylpyridine
Purity: 97%
Packaging: 1g
Price: $34.19
Updated: 2025/07/31

Sigma-Aldrich

Product number: 662704
Product name: 5-Amino-2-methylpyridine
Purity: 97%
Packaging: 250mg
Price: $33
Updated: 2023/06/20

TCI Chemical

Product number: A2053
Product name: 5-Amino-2-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: A2053
Product name: 5-Amino-2-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2025/07/31

TRC

Product number: M327020
Product name: 6-Methylpyridine-3-amine
Packaging: 5g
Price: $495
Updated: 2021/12/16

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5-Amino-2-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

White to orange to brown solid

Uses

6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.

General Description

5-Amino-2-methylpyridine is used as a pharmaceutical intermediate for Omecamtiv Mecarbil, a selective cardiac myosin activator used to improve cardiac function.

Synthesis

21203-68-9

80287-53-2

To a 250 mL autoclave was added 100 mL of methanol (MeOH), 2-methyl-5-nitropyridine (15 g, 0.19 mol, 1.0 eq.) and 10% palladium/carbon catalyst (0.5 g, 3.3 wt%). The reaction mixture was stirred at room temperature for 18 h under 4 atm hydrogen pressure. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 3:1) to confirm the completion of the reaction. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure to afford 3-amino-6-methylpyridine (11.5 g, HPLC purity: 97%) as a dark red solid in 98.3% yield.

References

[1] Patent: WO2018/208630, 2018, A1. Location in patent: Page/Page column 55
[2] Patent: US5580872, 1996, A
[3] Patent: US5733912, 1998, A
[4] Chemische Berichte, 1939, vol. 72, p. 577,579
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 22, p. 4676 - 4686

5-Amino-2-methylpyridine Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Ethanol 2-Picoline Palladium 1,4-Dioxane Tetrahydrofuran Trifluoroacetic anhydride Sulfuryl chloride Ethyl acetate Hydrochloric acid Nitric acid Bromine Sodium hydroxide Diethyl malonate 2-Chloro-5-nitropyridine Isopropyl alcohol Methyl 6-methylnicotinate Ammonia Sodium metabisulfite

Preparation Products

5-METHOXYPYRIDINE-2-CARBOXYLIC ACID 6-IODO-5-METHOXY-2-PYRIDINECARBOXYLIC ACID diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate Nalidixic acid ethyl 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate 2-IODO-3-METHOXY-6-METHYLPYRIDINE 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 2-Amino-5-hydroxypyridine 3-Hydroxy-2-iodo-6-methylpyridine 3-Hydroxy-6-methylpyridine 5-HYDROXYPYRIDINE-2-CARBOHYDRAZIDE 5-Chloropyridine-2-carboxylic acid 5-METHOXY-2-METHYLPYRIDINE 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID 5-Aminopyridine-2-carboxylic Acid 6-Bromo-5-methoxypicolinic acid 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

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5-Amino-2-methylpyridine Suppliers

Americas 1 Austria 1 Canada 3 China 435 Europe 4 France 1 Germany 7 India 44 Japan 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 20 United States 54 Global 575

Shanghai Meilv Pharmatech Co. Ltd

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Qingdao Fansen Biotechnology Co., Ltd

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Hangzhou Zhixi Biomedical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from 5-Amino-2-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Amino-2-methylpyridine 3430-14-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Amino-2-methylpyridine 3430-14-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Amino-2-methylpyridine 3430-14-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

3430-14-6, 5-Amino-2-methylpyridineRelated Search:

2,2-Dimethylbutyric acid 2,2-DIMETHYLVALERIC ACID 2,2-Dimethylbutyryl chloride (2-Methyl-6-trifluoromethylpyridin-3-yl)amine 2,6-Dimethyl-3-nitropyridine 2.4.6-TRIMETHYL-3-NITROPYRIDINE 2-Amino-3,5-dinitro-6-methylpyridine 5-Amino-2-methylpyridine Streptonigrin 3-AMINO-2,6-DIMETHYLPYRIDINE ETHYL 2-METHYL-5-NITRONICOTINATE 2-Amino-3-nitro-6-picoline Elbanizine 5-Amino-3-methylpyridine-2-carbonitrile,5-AMINO-3-METHYLPYRIDINE-2-CARBONITRILE,PURITY:95% MIN(HPLC) 2,6-Dibromopyridin-3-amine 2-(BOC-AMINO)-5-PICOLINE 3-Amino-6-fluoro-2-methylpyridine 3-Pyridinecarboxylicacid,2-amino-5-methyl-(9CI)

6-Methylpyridin-3-amine, 5-Amino-2-picoline

5-Amino-2-methylpyridine,97%

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5-Amino-2-methylpyridine 97%

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5-AMINO-2-METHYLPYRIDINE

5-AMINO-2-PICOLINE

3-AMINO-6-PICOLINE

3-AMINO-6-METHYLPYRIDINE

2-METHYL-5-AMINOPYRIDINE

2-Methyl-5-Aminoyridine

6-Methyl-Pyridin-3-yl

6-Methylpyridine-3-Amine

3-Pyridinamine,6-methyl-(9CI)

AURORA KA-7923

6-Methyl-3-aminopyridine

2-METHYL-5-AMINOPYRIDINE / 3-AMINO-6-PICOLINE

5-AMINO-2-METHYLPYRIDINE (5-AMINO-2-PICOLINE)

3-Pyridinamine, 6-methyl-

5-amino-2-methylpyridine UNDER RD

6-Methylpyridin-3-amine

5-Amino-2-methylpyridine ,98%

3-amine-6-methylpyridine

5-Amino-2-methylpyri

5-Aminopicoline

5-Amino-2-methylpyridine &gt

5-Bromo-4-nitropicolinonitrile

5-Amino-2-methylpyridine ISO 9001：2015 REACH

5-Amino-2-methylpyridine/6-Methylpyridin-3-ylamine

Ritlecitinib Impurity 1

3430-14-6

3430146

Pyridines

Heterocyclic Building Blocks

Building Blocks

C6

Pyridine

Pyridine Series

Amines

Pyridines derivates

VARIOUSAMINE

pyridines