Streptonigrin
- Product Name
- Streptonigrin
- CAS No.
- 3930-19-6
- Chemical Name
- Streptonigrin
- Synonyms
- NIGRIN;5278r.p.;nsc45383;NSC 83950;NSC 56748;valacidin;phaeomycin;BRUNEOMYCIN;AO 50165L302;streptonigran
- CBNumber
- CB1333569
- Molecular Formula
- C25H22N4O8
- Formula Weight
- 506.46
- MOL File
- 3930-19-6.mol
Streptonigrin Property
- Melting point:
- 301-303℃
- Boiling point:
- 595.12°C (rough estimate)
- Density
- 1.4130 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform:Methanol (1:1): 2 mg/ml
- form
- A solid
- pka
- 6.2-6.4 (1:1 aq dioxane)
- color
- Light brown to brown
- Merck
- 13,8907
- BRN
- 599390
Safety
- Hazard Codes
- T+
- Risk Statements
- 28
- Safety Statements
- 53-28-36/37/39-45
- RIDADR
- UN 3462 6.1/PG 1
- WGK Germany
- 3
- RTECS
- TJ7350000
- F
- 10-18
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Toxicity
- LD50 oral in mouse: 2330ug/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S1014
- Product name
- Streptonigrin from Streptomyces flocculus
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $119
- Updated
- 2024/03/01
- Product number
- S1014
- Product name
- Streptonigrin from Streptomyces flocculus
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $432
- Updated
- 2024/03/01
- Product number
- 27952
- Product name
- Streptonigrin
- Packaging
- 1mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 27952
- Product name
- Streptonigrin
- Packaging
- 5mg
- Price
- $529
- Updated
- 2024/03/01
- Product number
- S7975-09
- Product name
- Streptonigrin
- Packaging
- 1mg
- Price
- $490
- Updated
- 2021/12/16
Streptonigrin Chemical Properties,Usage,Production
Description
Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities. Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.
Chemical Properties
Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions.
Uses
Streptonigrin is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Streptonigrin from Streptomyces flocculus
Uses
Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).
Definition
ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
brand name
Nigrin (Pfizer).
Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.
Purification Methods
Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961].
Streptonigrin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Streptonigrin manufacturers
- Product
- Streptonigrin 3930-19-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-15
- Product
- Streptonigrin 3930-19-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Streptonigrin 3930-19-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30