Methyl 6-methylnicotinate

Uses

Product Name: Methyl 6-methylnicotinate
CAS No.: 5470-70-2
Chemical Name: Methyl 6-methylnicotinate
Synonyms: METHYL 6-METHYLPYRIDINE-3-CARBOXYLATE;M6MN;6-Methyl Methyl Smoke;Etoricoxib Impurity E;LABOTEST-BB LT00847843;Methyl-6-methylnictinate;METHYL 6-METHYLNICOTINATE;5-CARBOMETHOXY-2-PICOLINE;Methyle6-methylnicotinate;Etoricoxib Intermediate 6
CBNumber: CB9730818
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 5470-70-2.mol

More

Less

Methyl 6-methylnicotinate Property

Melting point:: 34-37 °C (lit.)
Boiling point:: 160 °C/106 mmHg (lit.)
Density: 1.2023 (rough estimate)
refractive index: 1.5810 (estimate)
Flash point:: 218 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 3.92±0.10(Predicted)
form: Liquid
color: Clear colorless to slightly yellow
BRN: 122940
InChI: InChI=1S/C8H9NO2/c1-6-3-4-7(5-9-6)8(10)11-2/h3-5H,1-2H3
InChIKey: VYPPZXZHYDSBSJ-UHFFFAOYSA-N
SMILES: C1=NC(C)=CC=C1C(OC)=O
CAS DataBase Reference: 5470-70-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 284777
Product name: Methyl 6-methylpyridine-3-carboxylate
Purity: 97%
Packaging: 10g
Price: $148.4
Updated: 2025/07/31

TCI Chemical

Product number: M1893
Product name: Methyl 6-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: M1893
Product name: Methyl 6-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $113
Updated: 2025/07/31

Usbiological

Product number: M3515-01
Product name: Methyl 6-Methylnicotinate
Packaging: 5g
Price: $418
Updated: 2021/12/16

Usbiological

Product number: 281663
Product name: Methyl 6-methylnicotinate
Packaging: 5g
Price: $292
Updated: 2021/12/16

More

Less

Methyl 6-methylnicotinate Chemical Properties,Usage,Production

Uses

It is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.

Chemical Properties

Brown Solid

Uses

Methyl 6-methylpyridine-3-carboxylate may be used in chemical synthesis studies.

Uses

Methyl 6-methylnicotinate is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 97, p. 4409, 1975 DOI: 10.1021/ja00848a053

Synthesis

67-56-1

3222-47-7

5470-70-2

To a stirred solution of 6-methylpyridine-3-carboxylic acid (40 g; 290 mmol; 1 equiv.) in methanol (0.75 L) was slowly added concentrated sulfuric acid (40 mL), and the reaction mixture was heated to reflux and held for 17 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure. Subsequently, the pH of the residue was adjusted to 7 with ice-cold saturated aqueous NaHCO3 and solid NaHCO3. The aqueous layer was extracted with ethyl acetate (3 x 500 mL), the organic layers were combined, washed with saturated brine, dried with anhydrous sodium sulfate, and the solvent was removed by filtration and under reduced pressure to give methyl 6-methylnicotinate (33 g, 75% yield) as an off-white solid. The product was confirmed by 1H NMR (CDCl3): δ 9.06 (s, 1H), 8.13 (dd, 1H, J = 2,8Hz), 7.20 (d, 1H, J = 8Hz), 3.89 (s, 3H), 2.58 (s, 3H).LCMS analysis showed: m/z = 152.4 [M + H]+, retention time RT = 2.36 min (using program P1, column W).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0152; 0153; 0154
[2] Journal of Organic Chemistry, 1981, vol. 46, # 15, p. 3040 - 3048
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 23, p. 5005 - 5022
[4] Patent: WO2010/48010, 2010, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2013/128421, 2013, A1. Location in patent: Page/Page column 80

Methyl 6-methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

5-Amino-2-methylpyridine

More

Less

Methyl 6-methylnicotinate Suppliers

Americas 1 Australia 1 Canada 3 China 467 Europe 5 France 1 Germany 6 India 62 Japan 2 Slovakia 1 Switzerland 5 Ukraine 1 United Kingdom 17 United States 42 Global 614

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15553111391
Email: 3276840968@qq.com
Country: China
ProdList: 301
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shanghai Taijilin Industrial Co., Ltd.

Tel: 021-50630626 18964684208
Fax: 021-50563898
Email: kate@tajilin.com
Country: China
ProdList: 1291
Advantage: 58

Shanghai RC Chemicals Co. Ltd

Tel: 17305617782
Fax: 86-21-50322176
Email: sales1@rcc.net.cn
Country: China
ProdList: 208
Advantage: 55

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales11@btcpharm.com
Country: China
ProdList: 1250
Advantage: 58

Dezhou Honghai Pharmaceutical Technology Co., Ltd

Tel: +86-13285346120 13285346120
Email: 17658510842@163.com
Country: China
ProdList: 46
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: 18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 729
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

More

Less

View Lastest Price from Methyl 6-methylnicotinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl 6-methylnicotinate 5470-70-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 5000kg/month
Release date: 2023-01-05

Asia Chem I and E (Jiangsu) Co Ltd

Product: Methyl 6-methylpyridine-3-carboxylate 5470-70-2
Price: US $65.58/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 3tons/month
Release date: 2021-11-09

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Methyl 6-methylnicotinate 5470-70-2
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-06-07

5470-70-2, Methyl 6-methylnicotinateRelated Search:

Methyl methacrylate Methyl nicotinate Methylparaben Kresoxim-methyl Methyl 6-aminonicotinate METHYL 2-METHYLNICOTINATE Methyl cellulose METHYL THIOPHENE-2-CARBOXYLATE Methyl isonicotinate Sodium carboxymethyl cellulose Methyl indole-6-carboxylate METHYL 2-CHLORONICOTINATE Bensulfuron methyl Methacrylic acid N,N-Dimethylformamide Methyl acrylate Dimethyl sulfoxide Thiophanate-methyl

LABOTEST-BB LT00847843

METHYL 6-METHYLPYRIDINE-3-CARBOXYLATE

METHYL 6-METHYLNICOTINATE

6-METHYL PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER

6-METHYLNICOTINIC ACID METHYL ESTER

5-CARBOMETHOXY-2-PICOLINE

3-PYRIDINECARBOXYLIC ACID, 6-METHYL-, METHYL ESTER

Methyl-6-methylnictinate

Methyl6-methylnicotinate,97+%

Methyl 6-methylnicotinate 97%

3-Pyridinecarboxylicacid,6-methyl-,methylester(9CI)

Methyl 2-methylpyridine-5-carboxylate

4-Methyl-5-(1-methyl-naphthalen-2-yloxymethyl)-4H-[1,2,4]triazole-3-thiol

6-Methylnicotinic Acid Methyl Ester Methyl 6-Methylpyridine-3-carboxylate 6-Methylpyridine-3-carboxylic Acid Methyl Ester

Methyl 6-methylpyridine-3-carboxylate, Methyl 2-methylpyridine-5-carboxylate, 5-(Methoxycarbonyl)-2-methylpyridine, 3-(Methoxycarbonyl)-6-methylpyridine

Methyl 6-methylpyridine-3-carboxylate 97%

6-methyl-3-pyridinecarboxylic acid methyl ester

Methyle6-methylnicotinate

6-Methyl Methyl Smoke

Etoricoxib Intermediate 6

Methyl 6-Methylnicotinate, 95+%

Etoricoxib Impurity E

Methyl6-Methylnicotinate&gt

M6MN

Methyl 6-methylnicotinate ISO 9001：2015 REACH

Methyl-6-Methylnicotinate (6-MNCT)

Etoricoxib Related Compound E

METHYL6 METHYL NICOTINATE (M6MN)

METHYLE 6 METHYLE NICOTINATE

Chemicalbook6-METHYLNICOTINICACIDMETHYLESTER

6-METHYLNICOTINATINIC ACID METHYL ESTER

Methyl-6-methyInicotinate

6- Methyl MethylNicotinate

Methyl 6-methyl-3-pyridinecarboxylate

Methyl 6-methylpyridin-3-carboxylate

5470-70-2

5770-70-2

Pyridines

Heterocyclic Building Blocks

C7 and C8

Building Blocks

Aromatics

Esters

Pyridines

Organic acids

Nicotine Derivatives

Pyridine

CARBOXYLICESTER

Acids and Derivatives

Heterocycles

bc0001