ChemicalBook > CAS DataBase List > Methyl 6-methylnicotinate
Methyl 6-methylnicotinate
Uses- Product Name
- Methyl 6-methylnicotinate
- CAS No.
- 5470-70-2
- Chemical Name
- Methyl 6-methylnicotinate
- Synonyms
- METHYL 6-METHYLPYRIDINE-3-CARBOXYLATE;M6MN;6-Methyl Methyl Smoke;Etoricoxib Impurity E;LABOTEST-BB LT00847843;Methyl-6-methylnictinate;METHYL 6-METHYLNICOTINATE;5-CARBOMETHOXY-2-PICOLINE;Methyle6-methylnicotinate;Etoricoxib Intermediate 6
- CBNumber
- CB9730818
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 5470-70-2.mol
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Methyl 6-methylnicotinate Property
- Melting point:
- 34-37 °C (lit.)
- Boiling point:
- 160 °C/106 mmHg (lit.)
- Density
- 1.2023 (rough estimate)
- refractive index
- 1.5810 (estimate)
- Flash point:
- 218 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 3.92±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to slightly yellow
- BRN
- 122940
- InChI
- InChI=1S/C8H9NO2/c1-6-3-4-7(5-9-6)8(10)11-2/h3-5H,1-2H3
- InChIKey
- VYPPZXZHYDSBSJ-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=CC=C1C(OC)=O
- CAS DataBase Reference
- 5470-70-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 284777
- Product name
- Methyl 6-methylpyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $148.4
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M1893
- Product name
- Methyl 6-Methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M1893
- Product name
- Methyl 6-Methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $113
- Updated
- 2025/07/31
Usbiological
- Product number
- M3515-01
- Product name
- Methyl 6-Methylnicotinate
- Packaging
- 5g
- Price
- $418
- Updated
- 2021/12/16
Usbiological
- Product number
- 281663
- Product name
- Methyl 6-methylnicotinate
- Packaging
- 5g
- Price
- $292
- Updated
- 2021/12/16
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Methyl 6-methylnicotinate Chemical Properties,Usage,Production
Uses
It is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.
Chemical Properties
Brown Solid
Uses
Methyl 6-methylpyridine-3-carboxylate may be used in chemical synthesis studies.
Uses
Methyl 6-methylnicotinate is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.
Synthesis Reference(s)
Journal of the American Chemical Society, 97, p. 4409, 1975 DOI: 10.1021/ja00848a053
Synthesis
67-56-1
3222-47-7
5470-70-2
To a stirred solution of 6-methylpyridine-3-carboxylic acid (40 g; 290 mmol; 1 equiv.) in methanol (0.75 L) was slowly added concentrated sulfuric acid (40 mL), and the reaction mixture was heated to reflux and held for 17 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure. Subsequently, the pH of the residue was adjusted to 7 with ice-cold saturated aqueous NaHCO3 and solid NaHCO3. The aqueous layer was extracted with ethyl acetate (3 x 500 mL), the organic layers were combined, washed with saturated brine, dried with anhydrous sodium sulfate, and the solvent was removed by filtration and under reduced pressure to give methyl 6-methylnicotinate (33 g, 75% yield) as an off-white solid. The product was confirmed by 1H NMR (CDCl3): δ 9.06 (s, 1H), 8.13 (dd, 1H, J = 2,8Hz), 7.20 (d, 1H, J = 8Hz), 3.89 (s, 3H), 2.58 (s, 3H).LCMS analysis showed: m/z = 152.4 [M + H]+, retention time RT = 2.36 min (using program P1, column W).
References
[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0152; 0153; 0154
[2] Journal of Organic Chemistry, 1981, vol. 46, # 15, p. 3040 - 3048
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 23, p. 5005 - 5022
[4] Patent: WO2010/48010, 2010, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2013/128421, 2013, A1. Location in patent: Page/Page column 80
Methyl 6-methylnicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 6-methylnicotinate manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Methyl 6-methylnicotinate 5470-70-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 5000kg/month
- Release date
- 2023-01-05
Asia Chem I and E (Jiangsu) Co Ltd
- Product
- Methyl 6-methylpyridine-3-carboxylate 5470-70-2
- Price
- US $65.58/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 3tons/month
- Release date
- 2021-11-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
- Product
- Methyl 6-methylnicotinate 5470-70-2
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-06-07
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