3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- Product Name
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- CAS No.
- 111669-25-1
- Chemical Name
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- Synonyms
- BUTTPARK 46\04-67;Palbociclib Impurity 169;1-Boc-4-(3-Aminopyridin-2-yl);2-(4-Boc-1-piperazinyl)pyridin-3-amine;1-Boc-4-(3-aMinopyridin-2-yl)piperazine;3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE;butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine;tert-butyl 4-(3-amino-2-pyridyl)piperazine-1-carboxylate;ert-butyl4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
- CBNumber
- CB7852848
- Molecular Formula
- C14H22N4O2
- Formula Weight
- 278.35
- MOL File
- 111669-25-1.mol
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Property
- Boiling point:
- 448.8±45.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.35±0.29(Predicted)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 45-37-26
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A595175
- Product name
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A595175
- Product name
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- JK282431
- Product name
- 3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- 074584
- Product name
- 1-Boc-4-(3-Aminopyridin-2-yl)piperazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- X8979
- Product name
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
- Packaging
- 5g
- Price
- $394
- Updated
- 2021/12/16
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Chemical Properties,Usage,Production
Chemical Properties
Grey to purple powder
Synthesis
153473-24-6
111669-25-1
Tert-butyl 4-(3-nitropyridin-2-yl)piperazine-1-carboxylate (350 mg, 1.14 mmol) was used as a raw material and mixed with Pd/C (60.4 mg, 10% w/w, 0.0568 mmol) and methanol (6 mL). The hydrogenation reaction was carried out at room temperature using a hydrogen balloon to provide a hydrogen atmosphere. The reaction mixture was stirred for 2 h and then filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent ratio hexane/EtOAc/CH2Cl2 = 1:1:1) to afford the target product tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate (246 mg, 78% yield) as a white powder. Mass spectrometry (EI) analysis resulted in a molecular ion peak (MH+) of 279.2 for C14H22N4O2.
References
[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 999 - 1014
[2] Patent: WO2012/61337, 2012, A1. Location in patent: Page/Page column 45
[3] Patent: WO2008/112440, 2008, A1. Location in patent: Page/Page column 38-39
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 11, p. 1406 - 1411
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 363 - 366
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine manufacturers
- Product
- 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine 111669-25-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31