3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 1458-16-8
- Chemical Name
- 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 3-aMino-6-iodopyra...;3-amino-6-iodopyrazine-2-carboxylate;Methyl3-amino-6-iodopyrazine-2-carboxylate,96%;3-amino-6-iodo-2-pyrazinecarboxylic acid methyl ester;3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;2-Pyrazinecarboxylic acid, 3-amino-6-iodo-, methyl ester
- CBNumber
- CB22452771
- Molecular Formula
- C6H6IN3O2
- Formula Weight
- 279.04
- MOL File
- 1458-16-8.mol
3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 200-202℃
- Boiling point:
- 387.9±42.0 °C(Predicted)
- Density
- 2.020±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C, protect from light
- form
- Solid
- pka
- -1.59±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H6IN3O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3,(H2,8,9)
- InChIKey
- FDLARAKNPMCCKJ-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(I)=CN=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M328773
- Product name
- Methyl3-amino-6-iodopyrazine-2-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J98925
- Product name
- Methyl3-amino-6-iodopyrazine-2-carboxylate
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- J98925
- Product name
- Methyl3-amino-6-iodopyrazine-2-carboxylate
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 072243
- Product name
- 3-Amino-6-iodopyrazine-2-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $352
- Updated
- 2021/12/16
- Product number
- 072243
- Product name
- 3-Amino-6-iodopyrazine-2-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $759
- Updated
- 2021/12/16
3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 3-amino-6-iodopyrazine-2-carboxylate
Synthesis
16298-03-6
1458-16-8
General procedure for the synthesis of methyl 3-amino-6-iodopyrazine-2-carboxylate from methyl 3-aminopyrazine-2-carboxylate: 1.5 equivalents of N-iodosuccinimide (NIS) was added to a 25 mL solution of dimethylformamide (DMF) containing 5 g (32.7 mmol) of methyl 3-aminopyrazine-2-carboxylate at room temperature. The reaction mixture was heated to 65 °C and after 1 hour of reaction, 0.5 equivalents of N-iodosuccinimide (NIS) was added and the reaction was continued at 65 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporation. Subsequently, the product was extracted several times with dichloromethane. The organic phases were combined, washed with 10% sodium bisulfite solution, dried over anhydrous magnesium sulfate, and concentrated to give 8 g (88% yield) of the yellow solid product methyl 3-amino-6-iodopyrazine-2-carboxylate. The product was analyzed by LC-MS (EI) at m/z (M+1) of 280. 1H NMR (400 MHz, DMSO-d6) δ: 8.50 (1H, s, Ar-H), 7.50 (2H, br s, NH2), 3.20 (3H, s, OCH3).
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 47, p. 11230 - 11233
[2] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 56
[3] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0288; 0289; 0290
[4] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0188
[5] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 55
3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 1458-16-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09