Methyl 3-amino-6-chloropyrazine-2-carboxylate
- Product Name
- Methyl 3-amino-6-chloropyrazine-2-carboxylate
- CAS No.
- 1458-03-3
- Chemical Name
- Methyl 3-amino-6-chloropyrazine-2-carboxylate
- Synonyms
- 2-Amino-5-chloro-3-pyrazinecarboxylic acid;Methyl 2-amino-5-chloropyrazine-3-carboxylate;Methyl 3-amino-6-chloropyrazine-2-carboxylate;Methyl3-amino-6-chloropyrazine-2-carboxylate,97%;3-aMino-6-chloropyrazine-2-carboxylate Methyl ester;3-Amino-6-chloro-2-pyrazinecarboxylic acid methyl ester;3-Amino-6-chloro-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 3-amino-6-chloro-, methyl ester
- CBNumber
- CB61570467
- Molecular Formula
- C6H6ClN3O2
- Formula Weight
- 187.58
- MOL File
- 1458-03-3.mol
Methyl 3-amino-6-chloropyrazine-2-carboxylate Property
- Melting point:
- 159-161 ºC
- Boiling point:
- 334.7±37.0 °C(Predicted)
- Density
- 1.465
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO, Methanol (Slightly)
- pka
- -1.67±0.10(Predicted)
- form
- Solid
- color
- Pale Yellow
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T316652
- Product name
- METHYL 3-AMINO-6-CHLORO-2-PYRAZINECARBOXYLATE
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $138
- Updated
- 2023/06/20
- Product number
- M328775
- Product name
- Methyl3-Amino-6-chloropyrazine-2-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H58-5-4M
- Product name
- Methyl 3-amino-6-chloropyrazine-2-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 073012
- Product name
- Methyl 3-amino-6-chloropyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 4H58-5-4M
- Product name
- Methyl 3-amino-6-chloropyrazine-2-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
Methyl 3-amino-6-chloropyrazine-2-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 3-Amino-6-chloropyrazine-2-carboxylate is a reagent used in the design and synthesis of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Synthesis
16298-03-6
1458-03-3
Methyl 3-aminopyrazine-2-carboxylate (100 g, 0.653 mol) was used as starting material, which was co-dissolved with N-chlorosuccinimide (NCS, 87.2 g, 0.653 mol) in acetonitrile (500 mL) in a 1 L three-neck flask. The reaction mixture was heated to 82 °C and the reaction was maintained at this temperature with stirring for 12 h to ensure complete reaction. Upon completion of the reaction, the acetonitrile solvent was removed by distillation under reduced pressure. The resulting crude product was purified by recrystallization using mixed petroleum ether/ethyl acetate solvent, and the final bright green crystalline target product, methyl 3-amino-6-chloropyrazine-2-carboxylate (112.7 g, 92% yield) was obtained.
References
[1] Patent: CN108101857, 2018, A. Location in patent: Paragraph 0032-0034
Methyl 3-amino-6-chloropyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-amino-6-chloropyrazine-2-carboxylate manufacturers
- Product
- Methyl 3-amino-6-chloropyrazine-2-carboxylate 1458-03-3
- Price
- US $4656.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-25
- Product
- Methyl 3-amino-6-chloropyrazine-2-carboxylate 1458-03-3
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20