2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE

Product Name: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
CAS No.: 72587-18-9
Chemical Name: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
Synonyms: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDIMINE;3-Amino-2-chloro-5-(trifluoromethyl)pyrid;2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE;2-Chloro-5-(trifluoroMethyl)pyridin-3-aMine;3-Amino-2-chloro-5-(trifluoromethyl)pyridine;5-(TRIFLUOROMETHYL)-3-AMINO-2-CHLOROPYRIDINE;2-Chloro-3-amine-5-(trifluoromethyl)pyridine;3-Pyridinamine, 2-chloro-5-(trifluoromethyl)-;2-Chloro-5-(trifluoromethyl)-pyridin-3-ylamine
CBNumber: CB02448589
Molecular Formula: C6H4ClF3N2
Formula Weight: 196.56
MOL File: 72587-18-9.mol

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2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Property

Boiling point:: 256.8±40.0 °C(Predicted)
Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -0.29±0.10(Predicted)
form: Solid
color: Off-white to brown
Water Solubility: Slightly soluble in water.
CAS DataBase Reference: 72587-18-9

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C351480
Product name: 2-Chloro-5-(trifluoromethyl)pyridin-3-amine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J51116
Product name: 2-Chloro-5-(trifluoromethyl)pyridin-3-amine
Packaging: 1g
Price: $30
Updated: 2021/12/16

Matrix Scientific

Product number: 054655
Product name: 3-Amino-2-chloro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $35
Updated: 2021/12/16

Apolloscientific

Product number: PC201291
Product name: 2-Chloro-5-(trifluoromethyl)pyridin-3-amine
Purity: 98%
Packaging: 5g
Price: $96
Updated: 2021/12/16

Matrix Scientific

Product number: 054655
Product name: 3-Amino-2-chloro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $139
Updated: 2021/12/16

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2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Chemical Properties,Usage,Production

Uses

It's employed as a intermediate for pharmaceutical.

Synthesis

72587-15-6

72587-18-9

The general procedure for the synthesis of 3-amino-2-chloro-5-(trifluoromethyl)pyridine from 5-(trifluoromethyl)-3-nitro-2-chloropyridine was as follows: zinc(II) dichloride dihydrate (4.39 g, 19.5 mmol) was added to 2-chloro-3-nitro-5-(trifluoromethyl)pyridine (1.00 g, 4.41 mmol) in ethyl acetate (25 mL) solution. The resulting suspension was stirred at 80°C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (100 mL). After the temperature was brought to room temperature, the product was separated. The suspension was filtered through a diatomaceous earth layer and the residue was washed four times with ethyl acetate (50 mL each time). The filtrate and washings were combined and washed sequentially with saturated sodium bicarbonate solution, water and saturated aqueous sodium chloride solution. The organic phase was dried over magnesium sulfate, filtered and concentrated to dryness. Yield: 0.78 g (90%). 1H-NMR (CD2Cl2, 400 MHz) data were as follows: δ=4.4 (br s, 2H), 7.24 (d, 1H), 8.02 (d, 1H).

References

[1] Patent: US2012/319050, 2012, A1. Location in patent: Page/Page column 64-65
[2] Patent: WO2012/172482, 2012, A1. Location in patent: Page/Page column 126
[3] Patent: WO2017/133657, 2017, A1. Location in patent: Page/Page column 64
[4] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 175; 176

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Suppliers

China 67 India 2 Switzerland 1 United Kingdom 1 United States 10 Global 81

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Chloro-5-(trifluoromethyl)-3-pyridinamine 72587-18-9
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 72587-18-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-13

Career Henan Chemical Co

Product: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 72587-18-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

72587-18-9, 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINERelated Search:

3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE 3-aMino-5-broMo-4-chloropyridine 3-Amino-6-trifluoromethyl-pyridin-2-ol 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 3-amino-6-chloropyrazine-2-carboxylic acid 3-AMINO-4-METHOXYPYRIDINE 3-AMINO-3-(4-CYANOPHENYL)PROPANOIC ACID 3-Amino-5-chloropyridin-2-ol HCl (3-aminopyrazin-2-yl)methanol 3-Amino-3-(4-methoxyphenyl)propionic acid 3-PYRIDINAMINE, 6-(1-METHYLETHYL)- 3-AMINO-5-HYDROXYBENZOIC ACID 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE Ferric sulfate 3-AMINO-2-CHLORO-5-PICOLINE 2-Chloro-5-trifluoromethylpyridine 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 5-(TRIFLUOROMETHYL)-3-NITRO-2-CHLOROPYRIDINE

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE

5-(TRIFLUOROMETHYL)-3-AMINO-2-CHLOROPYRIDINE

3-Amino-2-chloro-5-(trifluoromethyl)pyridine

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDIMINE

2-Chloro-5-(trifluoroMethyl)pyridin-3-aMine

3-Amino-2-chloro-5-(trifluoromethyl)pyrid

2-Chloro-3-amine-5-(trifluoromethyl)pyridine

3-Pyridinamine, 2-chloro-5-(trifluoromethyl)-

2-Chloro-5-(trifluoromethyl)-pyridin-3-ylamine

72587-18-9