METHYL PYRAZINE-2-CARBOXYLATE
- Product Name
- METHYL PYRAZINE-2-CARBOXYLATE
- CAS No.
- 6164-79-0
- Chemical Name
- METHYL PYRAZINE-2-CARBOXYLATE
- Synonyms
- METHYL PYRAZINOATE;METHYL PYRAZINE-2-CA;Aaptamine Impurity 9;METHYL PYRAZINECARBOXYLATE;METHYL 2-PYRAZINECARBOXYLATE;Pyrazinoic acid methyl ester;METHYL PYRAZINE-2-CARBOXYLATE;Pyrazinecarboxylic acid methyl;Methyl2-Pyrazinecarboxylate>Methylpyrazine-2-carboxylate,98%
- CBNumber
- CB5369861
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 6164-79-0.mol
METHYL PYRAZINE-2-CARBOXYLATE Property
- Melting point:
- 57-61 °C(lit.)
- Boiling point:
- 104°C/7mmHg(lit.)
- Density
- 1.213±0.06 g/cm3(Predicted)
- Flash point:
- >100°(212°F)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- pka
- -0.91±0.10(Predicted)
- color
- Clear colorless
- Merck
- 14,7959
- BRN
- 118345
- InChI
- InChI=1S/C6H6N2O2/c1-10-6(9)5-4-7-2-3-8-5/h2-4H,1H3
- InChIKey
- TWIIRMSFZNYMQE-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CN=C1
- LogP
- -0.230
- CAS DataBase Reference
- 6164-79-0(CAS DataBase Reference)
- EPA Substance Registry System
- Pyrazinecarboxylic acid, methyl ester (6164-79-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 519677
- Product name
- Methyl 2-pyrazinecarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $244
- Updated
- 2023/06/20
- Product number
- M2015
- Product name
- Methyl 2-Pyrazinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- M2015
- Product name
- Methyl 2-Pyrazinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $255
- Updated
- 2025/07/31
- Product number
- X3196
- Product name
- Methyl 2-pyrazinecarboxylate
- Packaging
- 500g
- Price
- $721
- Updated
- 2021/12/16
- Product number
- CHM0030814
- Product name
- METHYL PYRAZINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $746.88
- Updated
- 2021/12/16
METHYL PYRAZINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
67-56-1
98-97-5
6164-79-0
To a solution of 2-pyrazinecarboxylic acid (5.80 g, 46.5 mmol) in dichloromethane (100 mL) was slowly added oxalyl chloride (5.10 mL, 60.4 mmol), followed by the addition of a catalytic amount of DMF.The reaction mixture was stirred for 6 hr. at 23° C. The reaction was completed with the addition of methanol (30 mL). After completion of the reaction, methanol (30 mL) was added slowly and stirring was continued for 30 min. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed sequentially with saturated aqueous sodium bicarbonate (1 x 100 mL) and brine (1 x 100 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 3.38 g (53% yield) of the crude methyl pyrazine-2-carboxylate, which could be used in the next step of the reaction without further purification.1H NMR (400 MHz, CDCl3): δ 9.34 (d, 1H), 8.79 (d, 1H), 8.74 (dd, 1H), 4.06 (s 3H); LCMS (Method A): tR = 0.48 min, m/z 139.3 (M + H)+.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2843 - 2851
[2] Journal of the American Chemical Society, 1990, vol. 112, # 17, p. 6248 - 6254
[3] Patent: WO2004/48369, 2004, A1. Location in patent: Page 8
[4] Tetrahedron Letters, 2009, vol. 50, # 28, p. 4030 - 4032
[5] Patent: WO2016/207914, 2016, A2. Location in patent: Page/Page column 3; 13; 14
METHYL PYRAZINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL PYRAZINE-2-CARBOXYLATE manufacturers
- Product
- Methyl pyrazine-2-carboxylate 6164-79-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
- Product
- METHYL PYRAZINE-2-CARBOXYLATE 6164-79-0
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23