ChemicalBook > CAS DataBase List > 5-Hydroxypyrazine-2-carboxylic acid methyl ester
5-Hydroxypyrazine-2-carboxylic acid methyl ester
- Product Name
- 5-Hydroxypyrazine-2-carboxylic acid methyl ester
- CAS No.
- 13924-95-3
- Chemical Name
- 5-Hydroxypyrazine-2-carboxylic acid methyl ester
- Synonyms
- CBI-BB ZERO/008486;Methyl 5-hydropyrazine-2-carboxylate;METHYL 5-HYDROXYPYRAZINE-2-CARBOXYLATE;methyl-5-hydroxy-2-pyrazinecarboxylate;methyl 6-oxo-1H-pyrazine-3-carboxylate;Methyl 5-hydroxypyrazine-2-carboxylate 95%;methyl 5-oxo-4,5-dihydropyrazine-2-carboxylate;Methyl 5-oxo-4,5-dihydro-2-pyrazinecarboxylate;5-Hydrocy-pyrazine-2-carboxylic acid methyl ester;5-HYDROXY-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB7247194
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 13924-95-3.mol
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5-Hydroxypyrazine-2-carboxylic acid methyl ester Property
- Melting point:
- 183-185 °C
- Density
- 1.39
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.55±0.40(Predicted)
- Appearance
- White to light brown Solid
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Safety
- HS Code
- 2933998090
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N-Bromosuccinimide Price
TRC
- Product number
- H952755
- Product name
- 5-Hydroxypyrazine-2-carboxylicAcidMethylEster
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 072544
- Product name
- Methyl 5-hydroxypyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M3260
- Product name
- Pyrazinecarboxylicacid,4,5-dihydro-5-oxo-,methylester
- Packaging
- 5g
- Price
- $66
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M3260
- Product name
- Pyrazinecarboxylicacid,4,5-dihydro-5-oxo-,methylester
- Packaging
- 10g
- Price
- $113
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 072544
- Product name
- Methyl 5-hydroxypyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $135
- Updated
- 2021/12/16
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5-Hydroxypyrazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester is a metabolite of Pyrazinamide (P840600), an antibacterial (tuberculostatic).
Synthesis
67-56-1
34604-60-9
13924-95-3
General procedure for the synthesis of methyl 5-hydroxypyrazine-2-carboxylate from methanol and 5-oxo-4,5-dihydropyrazine-2-carboxylic acid: Acetyl chloride (152 mL, 2.08 mol) was slowly added dropwise to methanol (5 L) at -20 °C. After the dropwise addition was completed, stirring was continued at this temperature for 30 minutes. Subsequently, 5-hydroxypyrazine-2-carboxylic acid (100 g, 714 mmol) was added and the mixture was heated to reflux and the reaction was maintained for 2 hours. Upon completion of the reaction, the solvent was removed by vacuum concentration and the residue was recrystallized from methanol (400 mL) to give 71 g (464 mmol) of methyl 5-hydroxypyrazine-2-carboxylate in 65% yield.
References
[1] Patent: WO2013/14567, 2013, A1. Location in patent: Page/Page column 80-81
[2] Patent: EP2239253, 2010, A1. Location in patent: Page/Page column 96
[3] Patent: EP1452525, 2004, A1. Location in patent: Page 15
5-Hydroxypyrazine-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Hydroxypyrazine-2-carboxylic acid methyl ester manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- Methyl5-hydroxypyrazine-2-carboxylate 13924-95-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
Career Henan Chemical Co
- Product
- 5-Hydroxypyrazine-2-carboxylic acid methyl ester 13924-95-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 469
- Release date
- 2019-09-01
13924-95-3, 5-Hydroxypyrazine-2-carboxylic acid methyl esterRelated Search:
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