Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- Product Name
- Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- CAS No.
- 118853-60-4
- Chemical Name
- Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- Synonyms
- 6-Aminopyrazine-2-carboxyL;methyl 6-aminopyrazine-2-car;Methyl 6-aminopyrazine-2-carboxylate;Methyl 6-amino-2-pyrazinecarboxylate;6-Aminopyrazinecarboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 6-amino-, methyl ester;Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- CBNumber
- CB91064150
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 118853-60-4.mol
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Property
- Boiling point:
- 341.2±37.0 °C(Predicted)
- Density
- 1.319
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.22±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C6H7N3O2/c1-11-6(10)4-2-8-3-5(7)9-4/h2-3H,1H3,(H2,7,9)
- InChIKey
- MFQOPTGQOOILCR-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(N)=CN=C1
Safety
- HS Code
- 2922390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M220940
- Product name
- Methyl6-Aminopyrazine-2-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR302497
- Product name
- Methyl 6-aminopyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 4H58-1-7U
- Product name
- Methyl 6-aminopyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 073394
- Product name
- Methyl 6-aminopyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- OR302497
- Product name
- Methyl 6-aminopyrazine-2-carboxylate
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Chemical Properties,Usage,Production
Uses
Methyl 6-Aminopyrazine-2-carboxylate is used in preparation of bicyclic compounds for use in antibacterial applications.
Synthesis
23611-75-8
118853-60-4
General procedure for the synthesis of methyl 6-amino-2-pyrazinecarboxylate from methyl 6-chloropyrazine-2-carboxylate: methyl 6-chloropyrazine-2-carboxylate (2 g, 0.0115 mol) was dissolved in 80 mL of dimethylsulfoxide (DMSO). To this solution, sodium azide (3 g, 0.0463 mol) and triphenylphosphine (4.6 g, 0.01738 mol) were sequentially added, followed by refluxing the reaction mixture at 120 °C for 4 hours. Upon completion of the reaction, 20 mL of 1 N hydrochloric acid solution was added to the mixture and the reaction was continued at 120 °C for 2 hours. At the end of the reaction, the mixture was cooled to room temperature and neutralized with aqueous sodium bicarbonate solution, followed by extraction of the target product with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated, and the residue was washed with n-pentane to give 1.4 g of methyl 6-amino-2-pyrazinecarboxylate as a yellow solid in 82.4% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.28-8.27 (m, 1H), 8.07 (s, 1H), 6.90 (s, 2H), 3.84 (s, 3H). Molecular weight of the molecular formula C6H7N3O2 is 153.14; mass spectrum (ESI) m/z: [M + H]+: 154.05.
References
[1] European Journal of Pharmaceutical Sciences, 2018, vol. 124, p. 165 - 181
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) manufacturers
- Product
- Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) 118853-60-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01