Aminopyrazine
- Product Name
- Aminopyrazine
- CAS No.
- 5049-61-6
- Chemical Name
- Aminopyrazine
- Synonyms
- PYRAZIN-2-AMINE;2-AMINOPYRAZINE;PYRAZINAMINE;APZ;NSC 13147;ENT 60202;PYRAZINEAMINE;AMINOPYRAZINE;2-Pyrazinamine;3-Aminopyrazine
- CBNumber
- CB3244650
- Molecular Formula
- C4H5N3
- Formula Weight
- 95.1
- MOL File
- 5049-61-6.mol
Aminopyrazine Property
- Melting point:
- 118-120 °C (lit.)
- Boiling point:
- 167.6°C (rough estimate)
- Density
- 1.1031 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 3.22±0.10(Predicted)
- form
- Crystalline Powder
- color
- Slightly yellow to beige
- Water Solubility
- soluble
- BRN
- 107025
- InChIKey
- XFTQRUTUGRCSGO-UHFFFAOYSA-N
- LogP
- -0.070
- CAS DataBase Reference
- 5049-61-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Aminopyrazine(5049-61-6)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 36/37/38-11
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29339990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A76958
- Product name
- Aminopyrazine
- Purity
- 98%
- Packaging
- 10g
- Price
- $60.3
- Updated
- 2025/07/31
- Product number
- A76958
- Product name
- Aminopyrazine
- Purity
- 98%
- Packaging
- 50g
- Price
- $252
- Updated
- 2023/06/20
- Product number
- A0989
- Product name
- 2-Aminopyrazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- A0989
- Product name
- 2-Aminopyrazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- 10007093
- Product name
- 2-Aminopyrazine
- Purity
- >98%
- Packaging
- 5g
- Price
- $19
- Updated
- 2024/03/01
Aminopyrazine Chemical Properties,Usage,Production
Chemical Properties
SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER
Uses
2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines.
Application
2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines.
Definition
ChEBI: Aminopyrazine is a member of pyrazines.
Synthesis
19847-12-2
5049-61-6
General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield.
References
[1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014
Aminopyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminopyrazine manufacturers
- Product
- Aminopyrazine 5049-61-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-26
- Product
- Aminopyrazine 5049-61-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- Aminopyrazine 5049-61-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10ton
- Release date
- 2024-07-22