Methyl 3-amino-2-pyrazinecarboxylate
- Product Name
- Methyl 3-amino-2-pyrazinecarboxylate
- CAS No.
- 16298-03-6
- Chemical Name
- Methyl 3-amino-2-pyrazinecarboxylate
- Synonyms
- METHYL 3-AMINOPYRAZINE-2-CARBOXYLATE;3-AMINOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;AKOS 90402;NSC 123649;BUTTPARK 35\02-15;TIMTEC-BB SBB004048;Methyl 3-amino-2-pyr;2-aMino-pyrazine-2-Methyl;3-amino-2-pyrazinecarboxyL;methyl 3-aminopyrazinecarboxylate
- CBNumber
- CB1353338
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 16298-03-6.mol
Methyl 3-amino-2-pyrazinecarboxylate Property
- Melting point:
- 169-172 °C (lit.)
- Boiling point:
- 300.8±37.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform, Methanol
- pka
- -0.30±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow
- BRN
- 127495
- InChIKey
- INCSQLZZXBPATR-UHFFFAOYSA-N
- LogP
- 0.2 at 20℃ and pH7
- Surface tension
- 73.3mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 16298-03-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37/39-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 276154
- Product name
- Methyl 3-amino-2-pyrazinecarboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $58.2
- Updated
- 2025/07/31
- Product number
- A1186
- Product name
- Methyl 3-Aminopyrazine-2-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- A1186
- Product name
- Methyl 3-Aminopyrazine-2-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- A1186
- Product name
- Methyl 3-Aminopyrazine-2-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- A628935
- Product name
- 3-Amino-2-pyrazinecarboxylicAcidMethylEster
- Packaging
- 50g
- Price
- $265
- Updated
- 2021/12/16
Methyl 3-amino-2-pyrazinecarboxylate Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
Methyl 3-amino-2-pyrazinecarboxylate has been used in:
- synthesis of 2-arylpteridin-4-ones and piperazine-derived 2-furan-2-yl-[1,2,4]triazolo[1,5-a] pyrazines
- reactions with isocyanates and aroyl chlorides for conversion to pteridinediones
Definition
ChEBI: Methyl 3-aminopyrazine-2-carboxylate is a pyrazine that is substituted by a methoxycarbonyl group at position 2 and an amino group at position 3. It is a member of pyrazines, a methyl ester and an aromatic amine.
Synthesis
67-56-1
5424-01-1
16298-03-6
General procedure for the synthesis of methyl 3-aminopyrazine-2-carboxylate from methanol and 3-aminopyrazine-2-carboxylic acid: 3-aminopyrazine-2-carboxylic acid (5 g, 1 eq.) was added to methanol (50 ml) followed by the slow addition of concentrated sulphuric acid (4 eq.) under ice-water bath conditions. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC) until completion of the reaction. Upon completion of the reaction, the reaction solution was concentrated and the pH was adjusted with saturated sodium carbonate solution to 8. The precipitate was collected by filtration and dried at 50 °C for 2 h to afford methyl 3-aminopyrazine-2-carboxylate as a brown solid (4.18 g, 76% yield).
Purification Methods
The ester forms yellow needles from H2O (100 parts using charcoal). If it contains the free acid (see IR), then dissolve it in CH2Cl2, wash it with saturated aqueous Na2CO3, brine, dry over MgSO4 filter, evaporate and recrystallise the residue. The free acid has m 203-204o (dec) [UV: Brown & Mason J Chem Soc 3443 1956] and pK1 <1 and pK2 3.70. The ammonium salt has m 232o(dec) (from aqueous Me2CO) and the amide has m 239.2o (from H2O) [Ellingson et al. J Am Chem Soc 67 1711 1945]. [Beilstein 25 III/IV 4412.]
References
[1] Journal of Molecular Structure, 2005, vol. 741, # 1-3, p. 67 - 75
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2784 - 2788
[3] Patent: CN106866553, 2017, A. Location in patent: Paragraph 0137; 0138; 0139; 0140
[4] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 4, p. 865 - 872
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10475 - 10489
Methyl 3-amino-2-pyrazinecarboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl 3-amino-2-pyrazinecarboxylate manufacturers
- Product
- Methyl 3-amino-2-pyrazinecarboxylate 16298-03-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-23
- Product
- Methyl 3-amino-2-pyrazinecarboxylate 16298-03-6
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20
- Product
- Methyl 3-amino-2-pyrazinecarboxylate 16298-03-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13