Methyl 5-chloropyrazine-2-carboxylate
- Product Name
- Methyl 5-chloropyrazine-2-carboxylate
- CAS No.
- 33332-25-1
- Chemical Name
- Methyl 5-chloropyrazine-2-carboxylate
- Synonyms
- 5-chloropyrazinecarboxy;Methyl 5-chloropyrazine-2...;2-chloro-5-carboMethoxy-pyrazine;5-Chloro-2-methoxycarbonylpyrazine;Methyl 5-Chloropyrazinecarboxylate;methyl-5-chlorpyrazin-2-carboxylat;2-Chloro-5-(methoxycarbonyl)pyrazine;5-Chloropyrazine-2-methylcarboxylate;METHYL 5-CHLOROPYRAZINE-2-CARBOXYLATE;Methyl-5-chloro-2-pyrazinecarboxylate
- CBNumber
- CB3754209
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 33332-25-1.mol
Methyl 5-chloropyrazine-2-carboxylate Property
- Melting point:
- 89-90 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 242.8±35.0 °C(Predicted)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Solid
- pka
- -4.54±0.10(Predicted)
- Appearance
- Light brown to gray Solid
- InChI
- InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-9-5(7)3-8-4/h2-3H,1H3
- InChIKey
- CVVMLRFXZPKILB-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=C(Cl)N=C1
- CAS DataBase Reference
- 33332-25-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M295713
- Product name
- Methyl5-chloropyrazine-2-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M295713
- Product name
- Methyl5-chloropyrazine-2-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 267450
- Product name
- 5-Chloro-2-methoxycarbonyl pyrazine
- Packaging
- 10g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- Q796
- Product name
- Methyl 5-chloro-2-pyrazinecarboxylate
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 058021
- Product name
- Methyl 5-chloropyrazine-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
Methyl 5-chloropyrazine-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Methyl 5-chloropyrazine-2-carboxylate has a melting point of 89-90°C, a boiling point of 242.8±35.0°C (Predicted), a density of 1.372±0.06 g/cm3 (Predicted), and an acidity factor (pKa) of -4.54±0.10 (Predicted).
Uses
Methyl 5-chloropyrazine-2-carboxylate can be used as an intermediate in many pharmaceuticals and pesticides. It can also be used as organic reaction reagent or other chemical products manufacturing.
Synthesis
13924-95-3
33332-25-1
General procedure for the synthesis of methyl 5-chloropyrazine-2-carboxylate from methyl 5-hydroxypyrazine-2-carboxylate: Methyl 5-hydroxypyrazine-2-carboxylate (673 mg, 4.37 mmol) was dissolved in phosphorus trichloride (6.1 mL), and a few drops of N,N-dimethylformamide were added as catalyst. The reaction mixture was heated to reflux for 2 h under nitrogen protection. After completion of the reaction, the reaction solution was slowly poured into ice water and extracted three times with chloroform (30 mL). The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate and saturated saline (100 mL each). The organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give methyl 5-chloropyrazine-2-carboxylate (611 mg, 81% yield) as a gray solid. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 4.05 (3H, s), 8.71 (1H, d, J = 1.6 Hz), 9.10 (1H, d, J = 1.2 Hz).
References
[1] Patent: EP2239253, 2010, A1. Location in patent: Page/Page column 96
[2] Patent: WO2013/14567, 2013, A1. Location in patent: Page/Page column 81
[3] Patent: EP1452525, 2004, A1. Location in patent: Page 15-16
Methyl 5-chloropyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-chloropyrazine-2-carboxylate manufacturers
- Product
- Methyl 5-chloropyrazine-2-carboxylate 33332-25-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- Methyl 5-chloropyrazine-2-carboxylate 33332-25-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
- Product
- Methyl 5-chloropyrazine-2-carboxylate 3332-25-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-08