5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
- Product Name
- 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
- CAS No.
- 36070-80-1
- Chemical Name
- 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
- Synonyms
- 5- chlorinepyrazine -2-;2-Carboxy-5-chloropyrazine;5-Chloro-pyridine-carboxylic;5-Chloropyrazine-2-carbox...;5-Chloropyrazinecarboxylic Acid;5-Chloropyrazine-2-carboxylicaci;5-chloropyrazine-2-carboxlic acid;5-Chloropyrazine-3-carboxylicacid;5-Chlopopyrazine-2-carboxylic acid;5-chloro-pyrazin-5-carboxylic acid
- CBNumber
- CB7810761
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 36070-80-1.mol
5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Property
- Melting point:
- 150-151℃
- Boiling point:
- 330.9±37.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.68±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C5H3ClN2O2/c6-4-2-7-3(1-8-4)5(9)10/h1-2H,(H,9,10)
- InChIKey
- FXJOTWLLDJYKAG-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(Cl)N=C1
- CAS DataBase Reference
- 36070-80-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- RIDADR
- UN2811
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3002
- Product name
- 5-Chloropyrazine-2-carboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- C381253
- Product name
- 5-Chloropyrazine-2-carboxylic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C381253
- Product name
- 5-Chloropyrazine-2-carboxylic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H56-5-1Z
- Product name
- 5-Chloropyrazine-2-carboxylic acid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 054028
- Product name
- 5-Chloropyrazine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
5-Chloropyrazine-2-carboxylic acid
Synthesis
33332-25-1
36070-80-1
Example 29: Synthesis of 5-[2(R)-(3-chloro-4-methylsulfonyl-phenyl)-3-cyclopentylpropylamino]-pyrazine-2-carboxylic acid hydroxylamides [000197] General steps: 1. dissolve methyl 5-chloropyrazine-2-carboxylate (30.00 g, 0.17 mol) in tetrahydrofuran (87 mL). 2. a solution of potassium carbonate (72.08 g, 0.52 mol) in water (261 mL) was added to the above solution. 3. The reaction mixture was stirred at 25 °C for 42 h. 4. 4. Upon completion of the reaction, the reaction mixture was acidified to a pH of about 2 with concentrated hydrochloric acid. 5. The reaction mixture was diluted with saturated aqueous sodium chloride solution (300 mL). 6. Extracted successively with ethyl acetate (4 L total) until no product was detected in the aqueous layer. 7. The organic layers were combined, dried over sodium sulfate and filtered. 8. The filtrate was concentrated in vacuum to give 5-chloropyrazine-2-carboxylic acid (26.54 g, 96% yield) as an off-white solid. Physical properties: melting point 150-151°C; EH-HRMS m/e calculated value C5H3ClN2O2 (M+) 157.9883, measured value 157.9877.
References
[1] Patent: WO2004/52869, 2004, A1. Location in patent: Page 115 - 116
[2] Patent: WO2006/66173, 2006, A2. Location in patent: Page/Page column 71-72
[3] Patent: US2010/210621, 2010, A1
[4] Patent: US2010/210841, 2010, A1. Location in patent: Page/Page column 18
[5] Organic Process Research and Development, 2017, vol. 21, # 3, p. 346 - 356
5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID manufacturers
- Product
- 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 36070-80-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 36070-80-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-Chloro-pyrazine-2-carboxylic acid 36070-80-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28