5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID

Product Name: 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
CAS No.: 36070-80-1
Chemical Name: 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
Synonyms: 5- chlorinepyrazine -2-;2-Carboxy-5-chloropyrazine;5-Chloro-pyridine-carboxylic;5-Chloropyrazine-2-carbox...;5-Chloropyrazinecarboxylic Acid;5-Chloropyrazine-2-carboxylicaci;5-chloropyrazine-2-carboxlic acid;5-Chloropyrazine-3-carboxylicacid;5-Chlopopyrazine-2-carboxylic acid;5-chloro-pyrazin-5-carboxylic acid
CBNumber: CB7810761
Molecular Formula: C5H3ClN2O2
Formula Weight: 158.54
MOL File: 36070-80-1.mol

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5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Property

Melting point:: 150-151℃
Boiling point:: 330.9±37.0 °C(Predicted)
Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.68±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C5H3ClN2O2/c6-4-2-7-3(1-8-4)5(9)10/h1-2H,(H,9,10)
InChIKey: FXJOTWLLDJYKAG-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=NC=C(Cl)N=C1
CAS DataBase Reference: 36070-80-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3002
Product name: 5-Chloropyrazine-2-carboxylic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $112
Updated: 2025/07/31

TRC

Product number: C381253
Product name: 5-Chloropyrazine-2-carboxylic Acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C381253
Product name: 5-Chloropyrazine-2-carboxylic Acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 054028
Product name: 5-Chloropyrazine-2-carboxylic acid
Purity: 95%
Packaging: 5g
Price: $88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC09567
Product name: 5-Chloropyrazine-2-carboxylic acid
Packaging: 25g
Price: $90
Updated: 2021/12/16

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5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

5-Chloropyrazine-2-carboxylic acid

Synthesis

33332-25-1

36070-80-1

Example 29: Synthesis of 5-[2(R)-(3-chloro-4-methylsulfonyl-phenyl)-3-cyclopentylpropylamino]-pyrazine-2-carboxylic acid hydroxylamides [000197] General steps: 1. dissolve methyl 5-chloropyrazine-2-carboxylate (30.00 g, 0.17 mol) in tetrahydrofuran (87 mL). 2. a solution of potassium carbonate (72.08 g, 0.52 mol) in water (261 mL) was added to the above solution. 3. The reaction mixture was stirred at 25 °C for 42 h. 4. 4. Upon completion of the reaction, the reaction mixture was acidified to a pH of about 2 with concentrated hydrochloric acid. 5. The reaction mixture was diluted with saturated aqueous sodium chloride solution (300 mL). 6. Extracted successively with ethyl acetate (4 L total) until no product was detected in the aqueous layer. 7. The organic layers were combined, dried over sodium sulfate and filtered. 8. The filtrate was concentrated in vacuum to give 5-chloropyrazine-2-carboxylic acid (26.54 g, 96% yield) as an off-white solid. Physical properties: melting point 150-151°C; EH-HRMS m/e calculated value C5H3ClN2O2 (M+) 157.9883, measured value 157.9877.

References

[1] Patent: WO2004/52869, 2004, A1. Location in patent: Page 115 - 116
[2] Patent: WO2006/66173, 2006, A2. Location in patent: Page/Page column 71-72
[3] Patent: US2010/210621, 2010, A1
[4] Patent: US2010/210841, 2010, A1. Location in patent: Page/Page column 18
[5] Organic Process Research and Development, 2017, vol. 21, # 3, p. 346 - 356

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Suppliers

Americas 1 Canada 1 China 237 Europe 1 France 1 Germany 5 India 13 Japan 2 Switzerland 1 United Kingdom 13 United States 31 Global 306

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View Lastest Price from 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 36070-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 36070-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-pyrazine-2-carboxylic acid 36070-80-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-28

36070-80-1, 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACIDRelated Search:

N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO 2-Chloropyrazine 2-Pyrazinecarboxylic acid 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER ETHYL 3-CHLORO-PYRAZINE-2-CARBOXYLATE 6-Chloropyrazine-2-carboxylic acid 3-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER METHYL 3-AMINO-5,6-DICHLORO-2-PYRAZINECARBOXYLATE 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 3,5-Dichloropyrazine-2-carboxyamide METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE 3-chloro-pyrazine-2-carboxylic acid methyl ester 6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID RARECHEM AL BO 0788 3-AMINO-5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID

5-CHLORO-2-PYRAZINECARBOXYLICACID(MFCD00190599)

5-Chloro-2-pyrazinecarboxylic acid

5-chloro-pyrazin-5-carboxylic acid

5-Chlopopyrazine-2-carboxylic acid

5-Chloro-2-pyrazine caSNoxylic acid

5-CHLORO-PYRAZINE-2-CASNOXYLIC ACID

5-Chloropyrazine-3-carboxylicacid

5-chloropyrazine-2-carboxlic acid

5-Chloro-pyridine-carboxylic

5-Chloropyrazinecarboxylic Acid

5-Chloropyrazine-2-carbox...

2-Carboxy-5-chloropyrazine

2-Pyrazinecarboxylic acid, 5-chloro-

2-Carboxy-5-chloropyrazine, 2-Carboxy-5-chloro-1,4-diazine

5- chlorinepyrazine -2-

5-Chloropyrazine-2-carboxylicacid,95%

5-CHOLRO-PYRAZINE-2-CARBOXYLIC ACID

2-chloro-5-carboxylic acid pyrazine

5-Chloropyrazine-2-carboxylicAcid&gt

5-Chloropyrazine-2-carboxylicaci

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID ISO 9001：2015 REACH

3-chloro-pyrazine-6-carboxylic acid

5-Chloropyrazine-2-carboxylic acid, 97%

36070-80-1

API intermediates

Pyrazines

Piperazine series

Heterocycle-other series

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines