METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE
- Product Name
- METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE
- CAS No.
- 27825-21-4
- Chemical Name
- METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE
- Synonyms
- 3-Chloro-pyrazine-2-carbo...;METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE;Methyl 3-chloropyrazine-2-car boxylate;3-chloro-5-Methylpyrazine-2-carboxylate;Methyl3-Chloropyrazine-2-carboxylate>Methyl 3-chloropyrazine-2-carboxylate, 97+%;3-Chloro-2-pyrazinecarboxylic Acid Methyl Ester;Pyrazinecarboxylic acid, 3-chloro-, methyl ester;3-chloro-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 3-chloro-, methyl ester
- CBNumber
- CB3242555
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 27825-21-4.mol
METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE Property
- Melting point:
- 31-32 °C
- Boiling point:
- 89°C/2mmHg(lit.)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to lump
- pka
- -2.33±0.10(Predicted)
- color
- White to Orange to Green
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P234Keep only in original container.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P390Absorb spillage to prevent material damage.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M2648
- Product name
- Methyl 3-Chloropyrazine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $165
- Updated
- 2025/07/31
- Product number
- C379905
- Product name
- 3-Chloro-2-pyrazinecarboxylicAcidMethylEster
- Packaging
- 5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- C379905
- Product name
- 3-Chloro-2-pyrazinecarboxylicAcidMethylEster
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- HCH0036866
- Product name
- METHYL-3-CHLORO-2-PYRAZINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2044.35
- Updated
- 2021/12/16
- Product number
- 4H23-5-08
- Product name
- Methyl 3-chloropyrazine-2-carboxylate
- Purity
- 97%
- Packaging
- 5G
- Price
- $950
- Updated
- 2021/12/16
METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE Chemical Properties,Usage,Production
Uses
3-Chloro-2-pyrazinecarboxylic Acid Methyl Ester (cas# 27825-21-4) is a compound useful in organic synthesis.
Synthesis
67-56-1
27398-39-6
27825-21-4
General procedure for the synthesis of methyl 3-chloro-2-pyrazinecarboxylate from methanol and 2-chloropyrazine-3-carboxylic acid: 3-chloropyrazine-2-carboxylic acid (100 mg, 0.63 mmol) was dissolved in a solvent mixture (2 mL : 2 mL) of dichloromethane (DCM) and methanol (MeOH) at room temperature. To this solution was added trimethylsilyl diazomethane (TMSCHN2, 0.47 mL, 0.95 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of acetic acid (0.2 mL) and the reaction mixture was diluted with distilled water (2 mL). Subsequently, the aqueous phase was extracted with dichloromethane (4 mL × 3). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford methyl 3-chloro-2-pyrazinecarboxylate (100 mg) as a colorless oil. Analyzed by liquid chromatography-mass spectrometry (LRMS), the molecular ion peak m/z (M + H) was measured to be 173.0, which was consistent with the theoretical value of 173.0.
References
[1] Patent: WO2016/100157, 2016, A2. Location in patent: Page/Page column 54; 55
[2] Patent: WO2016/101119, 2016, A1. Location in patent: Page/Page column 42; 43
METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE manufacturers
- Product
- 3-Chloro-2-pyrazinecarboxylic Acid Methyl Ester 27825-21-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE 27825-21-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24