2-Amino-5-bromopyrazine

Product Name: 2-Amino-5-bromopyrazine
CAS No.: 59489-71-3
Chemical Name: 2-Amino-5-bromopyrazine
Synonyms: 5-BROMOPYRAZIN-2-AMINE;BUTTPARK 29\02-91;5-BROMOPYRAZINAMINE;2-Amino-5-bromopyraz;5-Bromo-2-pyrazinamie;5-BROMO-2-PYRAZINAMINE;2-aimo-5-bromopyrazine;5-Bromo-2-aminopyrazine;2-Bromo-5-aminopyrazine;2-AMINO-5-BROMOPYRAZINE
CBNumber: CB0446196
Molecular Formula: C4H4BrN3
Formula Weight: 174
MOL File: 59489-71-3.mol

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2-Amino-5-bromopyrazine Property

Melting point:: 113-117 °C (lit.)
Boiling point:: 274.2±35.0 °C(Predicted)
Density: 1.844±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Ethanol, Ethyl Acetate, Methanol
form: Brown Needles
pka: 1.66±0.10(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C4H4BrN3/c5-3-1-8-4(6)2-7-3/h1-2H,(H2,6,8)
InChIKey: KRRTXVSBTPCDOS-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(Br)N=C1
CAS DataBase Reference: 59489-71-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/38-43-44-36/37/38-20/21/22
Safety Statements: 26-37/39-45-36/37/39-22-36/
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 636320
Product name: 2-Amino-5-bromopyrazine
Purity: 97%
Packaging: 1g
Price: $97.4
Updated: 2025/07/31

TCI Chemical

Product number: A1683
Product name: 2-Amino-5-bromopyrazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: A1683
Product name: 2-Amino-5-bromopyrazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $134
Updated: 2025/07/31

TRC

Product number: A601845
Product name: 2-Amino-5-bromopyrazine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: A1375-84
Product name: 2-Amino-5-bromopyrazine
Packaging: 250mg
Price: $319
Updated: 2021/12/16

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2-Amino-5-bromopyrazine Chemical Properties,Usage,Production

Chemical Properties

Brown Needles

Uses

Used without prior protection of the amino group in a palladium-catalyzed cross-coupling with pyridylboronic acids leading to pyrazinylpyridines.

Synthesis

5049-61-6

59489-71-3

Example 1A Synthesis of 5-bromo-2-pyrazinamine: 2-Aminopyrazine (15.0 g, 157 mmol) was dissolved in dichloromethane (900 mL), N-bromosuccinimide (28.2 g, 159 mmol) was added, and the reaction was stirred for 3.5 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth (Celite?). The filtrate was treated with silica gel (300 g) and subsequently concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography with 30% ethyl acetate/hexane as eluent to give 22.09 g (81.5% yield) of the target compound 5-bromo-2-pyrazinamine. Mass spectrum (APCI(+)) m/z: 174 ([M + H]+); 1H NMR (300 MHz, CDCl3) δ: 8.09 (d, J = 1.4 Hz, 1H), 7.77 (d, J = 1.7 Hz, 1H), 4.30-4.78 (br s, 2H).

References

[1] Heterocycles, 2012, vol. 86, # 2, p. 1323 - 1339
[2] Patent: US2004/259885, 2004, A1. Location in patent: Page 9; 10
[3] Patent: US2004/34038, 2004, A1. Location in patent: Page/Page column 10
[4] Patent: WO2011/7314, 2011, A1. Location in patent: Page/Page column 27
[5] Patent: WO2009/44162, 2009, A1. Location in patent: Page/Page column 169

2-Amino-5-bromopyrazine Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Aminopyrazine Dichloromethane Magnesium sulfate Sodium carbonate

Preparation Products

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2-Amino-5-bromopyrazine Suppliers

Americas 1 Belgium 2 Canada 3 China 346 Czech Republic 1 Europe 1 France 2 Germany 6 Hungary 1 India 21 Japan 3 Switzerland 2 The Netherlands 1 United Kingdom 13 United States 55 Global 458

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 991
Advantage: 62

Nanjing Jubai Biomedical Technology Co., Ltd.

Tel: 13585203734
Email: info@jbzml.com
Country: China
ProdList: 99
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Nanjing Yingkun Chemical Co., Ltd

Tel: 025-83212803 13382003766
Email: sales@yingkunchem.cn
Country: China
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Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
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Lanzhou Kangyuxin Biotechnology Co., Ltd.

Tel: 0931-4190454 13893344397
Email: sales@kyxpharma.com
Country: China
ProdList: 3031
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-021-61259138 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

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View Lastest Price from 2-Amino-5-bromopyrazine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-5-bromopyrazine 59489-71-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Shaanxi Haibo Biotechnology Co., Ltd

Product: 2-Amino-5-bromopyrazine 59489-71-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-31

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-5-bromopyrazine 59489-71-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

59489-71-3, 2-Amino-5-bromopyrazineRelated Search:

Mestinon 3-Aminophenol 6-Aminocaproic acid Aminopyrazine 2-Bromopyrazine Sulfachoropyrazine sodium Glipizide Pyrazinamide ALTRENOGEST Glycine Tris(hydroxymethyl)aminomethane Bromine 3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE,3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE, 95+% METHYL 3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLATE,3-Amino-6-bromopyrazine-2-carboxylic acid methyl ester 2-AMINO-5-BROMO-3-PYRROLIDIN-1-YLPYRAZINE 5-BROMO-PYRAZINE-2,3-DIAMINE 5-BROMO-3-(2-PYRIDIN-3-YL-PYRROLIDIN-1-YL)-PYRAZIN-2-YLAMINE 6'-BROMO-3-PHENYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRAZINYL-3'-YLAMINE

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2-Amino-5-bromopyrazine ISO 9001：2015 REACH

59489-71-3

59487-71-3

58489-71-3

C4H4N3Br

Heterocyclic Building Blocks

Halogenated Heterocycles

Chloropyrazines, etc.

Pyrazines

Building Blocks

amine| alkyl bromide

Chloropyrazines, etc.

Bases & Related Reagents

Nucleotides

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrazinesHeterocyclic Building Blocks

Halides

Pyrazines, Pyrimidines & Pyridazines

Pyrazine

Nucleotides and Nucleosides

Pyrazines

pharmacetical

Amines and Anilines

Heterocycles

Amines

Aromatics

Building Blocks/Intermediates