ChemicalBook > CAS DataBase List > Methyl 3-amino-6-bromopyrazine-2-carboxylate
Methyl 3-amino-6-bromopyrazine-2-carboxylate
- Product Name
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
- CAS No.
- 6966-01-4
- Chemical Name
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
- Synonyms
- NSC 18700;C6H6BrN3O2-6966-01-4;Favipiravir Impurity 24;Favipiravir Impurity 17;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLATE;Methyl 3-amino-6-bromopyrazine-2-formate;2-Amino-5-bromo-3-(methoxycarbonyl)pyrazine;METHYL 3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLATE;Methyl 6-broMo-3-aMino-2-pyrazinecarboxylate;Methyl 6-BroMo-3-aMinopyrazine-2-carboxylate
- CBNumber
- CB1462247
- Molecular Formula
- C6H6BrN3O2
- Formula Weight
- 232.03
- MOL File
- 6966-01-4.mol
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Methyl 3-amino-6-bromopyrazine-2-carboxylate Property
- Melting point:
- 164-166?C
- Boiling point:
- 322.4±37.0 °C(Predicted)
- Density
- 1.754±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Chloroform, Ethyl Acetate, Methanol
- pka
- -1.74±0.10(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChI
- InChI=1S/C6H6BrN3O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3,(H2,8,9)
- InChIKey
- CNXSIRHOIFRMOB-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Br)=CN=C1N
- CAS DataBase Reference
- 6966-01-4
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 737313
- Product name
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
- Purity
- 95%
- Packaging
- 250MG
- Price
- $59.4
- Updated
- 2023/01/07
TCI Chemical
- Product number
- M2655
- Product name
- Methyl 3-Amino-6-bromopyrazine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $48
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2655
- Product name
- Methyl 3-Amino-6-bromopyrazine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $203
- Updated
- 2025/07/31
TRC
- Product number
- A601863
- Product name
- 2-Amino-5-bromopyrazine-3-carboxylicAcidMethylEster
- Packaging
- 5g
- Price
- $210
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA17616
- Product name
- 2-Amino-5-bromopyrazine-3-carboxylic acid methyl ester
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
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Methyl 3-amino-6-bromopyrazine-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Orange Solid
Uses
Pyrazine derivatives as Axl and C-Met receptor enzyme inhibitors.
Synthesis
16298-03-6
6966-01-4
General Steps: Example 1; Synthesis of 3-methyl-6-(4-(methylsulfonyl)phenyl)-N-phenylpiperazine-2-carboxamide (Compound IV-1) Method A: Step 1: Preparation of methyl 3-amino-6-bromopyrazine-2-carboxylate[A Methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) was mixed with N-bromosuccinimide (9.705 g, 54.53 mmol) in acetonitrile (100 mL), and the reaction was stirred for 16 hours at room temperature. After completion of the reaction, the precipitate was collected by filtration, washed with acetonitrile and dried to afford the target product methyl 3-amino-6-bromopyrazine-2-carboxylate as a yellow solid (11.68 g, 92% yield). 1H NMR (400.0 MHz, DMSO-d6) δ 3.85 (s, 3H), 7.55 (br s, 2H), 8.42 (s, 1H) ppm; MS (ES+) m/z 233.
References
[1] Patent: WO2007/61360, 2007, A2. Location in patent: Page/Page column 71
[2] Heterocycles, 2005, vol. 65, # 10, p. 2321 - 2327
[3] Patent: WO2004/92177, 2004, A1. Location in patent: Page 35-36
[4] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 84-85
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90
Methyl 3-amino-6-bromopyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-amino-6-bromopyrazine-2-carboxylate manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- Methyl 3-amino-6-bromopyrazine-2-carboxylate 6966-01-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
Career Henan Chemical Co
- Product
- Methyl 3-amino-6-bromopyrazine-2-carboxylate 6966-01-4
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23
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