6-Biopterin
- Product Name
- 6-Biopterin
- CAS No.
- 22150-76-1
- Chemical Name
- 6-Biopterin
- Synonyms
- BIOPTERIN;L-BIOPTERIN;pterinhb2;NSC-339699;6-BIOPTERIN;6-Biopterin, ≥97%;D-erythro-Biopterin;L-erythro-Biopterin;(1'R,2'S)-BIOPTERIN;L-Biopterin(6-Biopterin)
- CBNumber
- CB8691190
- Molecular Formula
- C9H11N5O3
- Formula Weight
- 237.22
- MOL File
- 22150-76-1.mol
6-Biopterin Property
- Melting point:
- >210°C dec.
- alpha
- D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH)
- Boiling point:
- 379.74°C (rough estimate)
- Density
- 1.3472 (rough estimate)
- refractive index
- 1.7610 (estimate)
- storage temp.
- 2-8°C
- solubility
- Aqueous Acid (Slightly, Heated, Sonicated)
- form
- White to pale yellow powder.
- pka
- 13.18±0.20(Predicted)
- color
- White to Light Yellow
- Merck
- 13,1229
- BRN
- 87860
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 22150-76-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B2517
- Product name
- 6-Biopterin
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- B2517
- Product name
- 6-Biopterin
- Purity
- ≥97%
- Packaging
- 25mg
- Price
- $405
- Updated
- 2024/03/01
- Product number
- 10007662
- Product name
- L-Biopterin
- Purity
- >98%
- Packaging
- 5mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 10007662
- Product name
- L-Biopterin
- Purity
- >98%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- B2517
- Product name
- 6-Biopterin
- Purity
- ≥97%
- Packaging
- 50mg
- Price
- $696
- Updated
- 2024/03/01
6-Biopterin Chemical Properties,Usage,Production
Description
6-Biopterin (L-Biopterin) is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
Chemical Properties
Crystalline Solid
Uses
L-Biopterin is a pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.
Definition
6-Biopterin is an enzymatic cofactor derived from pterin and involved in certain oxidation-reduction reactions. It is a biopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-biopterin.
Application
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.
Preparation
Biopterin is synthesized by reacting 2,4,5-triamino-6-hydroxypyrimidine with 5-deoxy-L-arabinosone in aqueous solution at pH of about 7.5 to 10, acidifying and then recrystallizing by dissolving in basic solution and precipitating with acid. 5-deoxy-L-arabinosone is prepared by oxidizing S-deoxy-L-arabinose, which is prepared from L-rhamnose, using cupric acetate.
Process for the synthesis of biopterin
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.
6-Biopterin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Biopterin manufacturers
- Product
- 6-Biopterin 22150-76-1
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24