ChemicalBook > CAS DataBase List > Aminopyrazine

Aminopyrazine

Product Name: Aminopyrazine
CAS No.: 5049-61-6
Chemical Name: Aminopyrazine
Synonyms: PYRAZIN-2-AMINE;2-AMINOPYRAZINE;PYRAZINAMINE;APZ;NSC 13147;ENT 60202;PYRAZINEAMINE;AMINOPYRAZINE;2-Pyrazinamine;3-Aminopyrazine
CBNumber: CB3244650
Molecular Formula: C4H5N3
Formula Weight: 95.1
MOL File: 5049-61-6.mol

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Aminopyrazine Property

Melting point:: 118-120 °C (lit.)
Boiling point:: 167.6°C (rough estimate)
Density: 1.1031 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
pka: 3.22±0.10(Predicted)
form: Crystalline Powder
color: Slightly yellow to beige
Water Solubility: soluble
BRN: 107025
InChIKey: XFTQRUTUGRCSGO-UHFFFAOYSA-N
LogP: -0.070
CAS DataBase Reference: 5049-61-6(CAS DataBase Reference)
NIST Chemistry Reference: Aminopyrazine(5049-61-6)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38-11
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A76958
Product name: Aminopyrazine
Purity: 98%
Packaging: 10g
Price: $60.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: A76958
Product name: Aminopyrazine
Purity: 98%
Packaging: 50g
Price: $252
Updated: 2023/06/20

TCI Chemical

Product number: A0989
Product name: 2-Aminopyrazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: A0989
Product name: 2-Aminopyrazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $101
Updated: 2025/07/31

Cayman Chemical

Product number: 10007093
Product name: 2-Aminopyrazine
Purity: >98%
Packaging: 5g
Price: $19
Updated: 2024/03/01

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Aminopyrazine Chemical Properties,Usage,Production

Chemical Properties

SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER

Uses

2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines.

Application

2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines.

Definition

ChEBI: Aminopyrazine is a member of pyrazines.

Synthesis

19847-12-2

5049-61-6

General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield.

References

[1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014

Aminopyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Amino-5-bromopyrazine METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE

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Aminopyrazine Suppliers

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View Lastest Price from Aminopyrazine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Aminopyrazine 5049-61-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-26

Henan Aochuang Chemical Co.,Ltd.

Product: Aminopyrazine 5049-61-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

JINING XINHE CHEMICAL CO., LTD

Product: Aminopyrazine 5049-61-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10ton
Release date: 2024-07-22

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5049-61-6

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