3-BROMO-4-CHLORO-5-NITROPYRIDINE

Application

Product Name: 3-BROMO-4-CHLORO-5-NITROPYRIDINE
CAS No.: 31872-63-6
Chemical Name: 3-BROMO-4-CHLORO-5-NITROPYRIDINE
Synonyms: 4-Chloro-5-Bromo-3-Nitropyridine;3-BROMO-4-CHLORO-5-NITROPYRIDINE;3-Nitro-4-chloro-5-bromopyridine;Pyridine, 3-broMo-4-chloro-5-nitro-;3-BroMo-4-chloro-5-nitropyridine HCl;3-BROMO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber: CB7664256
Molecular Formula: C5H2BrClN2O2
Formula Weight: 237.44
MOL File: 31872-63-6.mol

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3-BROMO-4-CHLORO-5-NITROPYRIDINE Property

Melting point:: 49-50℃
Boiling point:: 285℃
Density: 1.936
Flash point:: 126℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: -0.88±0.10(Predicted)
color: Light yellow
InChI: InChI=1S/C5H2BrClN2O2/c6-3-1-8-2-4(5(3)7)9(10)11/h1-2H
InChIKey: FTQGEZJTBYMEIH-UHFFFAOYSA-N
SMILES: C1=NC=C([N+]([O-])=O)C(Cl)=C1Br

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Safety

RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684593
Product name: 3-Bromo-4-chloro-5-nitropyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B684593
Product name: 3-Bromo-4-chloro-5-nitropyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 054606
Product name: 3-Bromo-4-chloro-5-nitropyridine
Purity: 97%
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: J50641
Product name: 3-Bromo-4-chloro-5-nitropyridine
Packaging: 1g
Price: $15
Updated: 2021/12/16

Matrix Scientific

Product number: 054606
Product name: 3-Bromo-4-chloro-5-nitropyridine
Purity: 97%
Packaging: 5g
Price: $39
Updated: 2021/12/16

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3-BROMO-4-CHLORO-5-NITROPYRIDINE Chemical Properties,Usage,Production

Application

3-Bromo-4-chloro-5-nitropyridine can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.

Synthesis

31872-65-8

31872-63-6

Step 2. Synthesis of 3-bromo-4-chloro-5-nitropyridine The product of Step 1, 3-bromo-4-hydroxy-5-nitropyridine (6.57 g, 30 mmol), was slowly added to phosphoryl chloride (50 mL) under ice bath cooling conditions. Subsequently, N,N-diethylaniline (4.77 mL, 30 mmol) was added dropwise to the stirring reaction mixture. The reaction mixture was gradually warmed to room temperature and then heated to reflux for 2 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was carefully poured into ice water. The aqueous phase was extracted with ether and the organic phases were combined and washed sequentially twice with water and once with brine. Finally, the organic phase was concentrated to give a brown oil, which solidified to the target product 3-bromo-4-chloro-5-nitropyridine in a yield of 8.01 g (yield >100%) after standing.

References

[1] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 26-27
[2] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 26-27
[3] Tetrahedron Letters, 2012, vol. 53, # 4, p. 377 - 379
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[5] Justus Liebigs Annalen der Chemie, 1937, vol. 529, p. 291

3-BROMO-4-CHLORO-5-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-4-CHLORO-5-NITROPYRIDINE Suppliers

China 167 India 8 United Kingdom 4 United States 13 Global 192

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Advantage: 76

Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
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Pure Chemistry Scientific Inc.

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Country: United States
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Accela ChemBio Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
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Email: info@chemlin.com.cn
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
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Nan Jing Dirise Chemcial Co.,LTD

Tel: 025-52161033 15312098939
Fax: 025-83254025
Email: sales@njdrschem.com
Country: China
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View Lastest Price from 3-BROMO-4-CHLORO-5-NITROPYRIDINE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 3-BROMO-4-CHLORO-5-NITROPYRIDINE 31872-63-6
Price: US $130.00-873.00/g
Min. Order: 50g
Purity: 99%
Supply Ability: 30
Release date: 2024-07-10

Dideu Industries Group Limited

Product: 3-BROMO-4-CHLORO-5-NITROPYRIDINE 31872-63-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-BROMO-4-CHLORO-5-NITROPYRIDINE 31872-63-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

31872-63-6, 3-BROMO-4-CHLORO-5-NITROPYRIDINERelated Search:

2-Bromopyridine Pyridine Pentachloropyridine 2-Cyanopyridine 3-bromo-4-cyclopropyl-5-fluoropyridine 4-BROMOPYRIDINE 2-BROMO-3-CHLORO-5-NITROPYRIDINE 5-BROMO-2-CHLORO-3-NITROPYRIDINE,5-BROMO-2-CHLORO-3-NITROPYRIDINE 98% 2-BROMO-6-CHLORO-3-NITROPYRIDINE 4-Chloro-3-nitropyridine 2-Amino-5-bromo-4-chloro-3-nitropyridine 3-BROMO-4-CHLORO-5-NITROPYRIDINE 2-BROMO-5-CHLORO-3-NITROPYRIDINE 2-bromo-5-chloro-2-nitropyridine 3-Bromo-2-chloro-5-nitropyridine 98%,3-BROMO-2-CHLORO-5-NITROPYRIDINE 3-Amino-4-chloropyridine 3-BROMO-4-CHLOROPYRIDINE HCL 4-BROMO-3-CHLORO-5-NITROPYRIDINE

3-BROMO-4-CHLORO-5-NITROPYRIDINE

Pyridine, 3-broMo-4-chloro-5-nitro-

3-Nitro-4-chloro-5-bromopyridine

3-BroMo-4-chloro-5-nitropyridine HCl

3-BROMO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH

4-Chloro-5-Bromo-3-Nitropyridine

31872-63-6

Heterocycle-Pyridine series

Boronic Acid

Pyridine Series

Pyridine