2-Amino-5-bromo-4-chloro-3-nitropyridine
- Product Name
- 2-Amino-5-bromo-4-chloro-3-nitropyridine
- CAS No.
- 942947-95-7
- Chemical Name
- 2-Amino-5-bromo-4-chloro-3-nitropyridine
- Synonyms
- 2-AMino-5-broMo-4-chloro-...;5-bromo-4-chloro-3-nitropyridin-2-amine;5-Bromo-4-chloro-3-nitro-2-pyridinamine;2-Amino-5-bromo-4-chloro-3-nitropyridine;2-Pyridinamine, 5-bromo-4-chloro-3-nitro-;5-Bromo-4-chloro-3-nitro-pyridin-2-ylamine;2-Amino-5-bromo-4-chloro-3-nitropyridine ISO 9001:2015 REACH
- CBNumber
- CB11504500
- Molecular Formula
- C5H3BrClN3O2
- Formula Weight
- 252.45
- MOL File
- 942947-95-7.mol
2-Amino-5-bromo-4-chloro-3-nitropyridine Property
- Boiling point:
- 338.4±37.0 °C(Predicted)
- Density
- 2.020
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.88±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H3BrClN3O2/c6-2-1-9-5(8)4(3(2)7)10(11)12/h1H,(H2,8,9)
- InChIKey
- BLGCPXIDEMLKMS-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C(Cl)=C1[N+]([O-])=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A602045
- Product name
- 2-Amino-5-bromo-4-chloro-3-nitropyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB142823
- Product name
- 5-Bromo-4-chloro-3-nitropyridin-2-amine
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 074513
- Product name
- 2-Amino-5-bromo-4-chloro-3-nitropyridine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 074513
- Product name
- 2-Amino-5-bromo-4-chloro-3-nitropyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- FB142823
- Product name
- 5-Bromo-4-chloro-3-nitropyridin-2-amine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
2-Amino-5-bromo-4-chloro-3-nitropyridine Chemical Properties,Usage,Production
Synthesis
6980-08-1
942947-95-7
General procedure for the synthesis of 2-amino-5-bromo-4-chloro-3-nitropyridine from 2-amino-3-nitro-4-chloropyridine: 4-chloro-3-nitropyridin-2-amine (2 g, 11.5 mmol) and N-bromosuccinimide (2.5 g, 13.8 mmol) were dissolved in acetonitrile (125 mL) and heated to react for 1 hr at 80 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The product was purified by fast column chromatography (silica gel, dichloromethane/ethyl acetate gradient elution, 0-5% ethyl acetate) to afford 2-amino-5-bromo-4-chloro-3-nitropyridine (2.9 g, 99% yield). Mass spectrum (electrospray ionization): calculated value C5H3BrClN3O2, 250.9; measured value m/z 251.8 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.42 (s, 1H), 7.37 (br s, 2H).
References
[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 111
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[4] Patent: WO2013/190320, 2013, A1. Location in patent: Paragraph 00119
2-Amino-5-bromo-4-chloro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-bromo-4-chloro-3-nitropyridine manufacturers
- Product
- 2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
- Price
- US $1.00-1.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 50tons
- Release date
- 2020-05-12
- Product
- 2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-22
- Product
- 2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02