ChemicalBook > CAS DataBase List > 2-Amino-5-bromo-4-chloro-3-nitropyridine

2-Amino-5-bromo-4-chloro-3-nitropyridine

Product Name
2-Amino-5-bromo-4-chloro-3-nitropyridine
CAS No.
942947-95-7
Chemical Name
2-Amino-5-bromo-4-chloro-3-nitropyridine
Synonyms
2-AMino-5-broMo-4-chloro-...;5-bromo-4-chloro-3-nitropyridin-2-amine;5-Bromo-4-chloro-3-nitro-2-pyridinamine;2-Amino-5-bromo-4-chloro-3-nitropyridine;2-Pyridinamine, 5-bromo-4-chloro-3-nitro-;5-Bromo-4-chloro-3-nitro-pyridin-2-ylamine;2-Amino-5-bromo-4-chloro-3-nitropyridine ISO 9001:2015 REACH
CBNumber
CB11504500
Molecular Formula
C5H3BrClN3O2
Formula Weight
252.45
MOL File
942947-95-7.mol
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2-Amino-5-bromo-4-chloro-3-nitropyridine Property

Boiling point:
338.4±37.0 °C(Predicted)
Density 
2.020
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-0.88±0.50(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C5H3BrClN3O2/c6-2-1-9-5(8)4(3(2)7)10(11)12/h1H,(H2,8,9)
InChIKey
BLGCPXIDEMLKMS-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C(Cl)=C1[N+]([O-])=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A602045
Product name
2-Amino-5-bromo-4-chloro-3-nitropyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
074513
Product name
2-Amino-5-bromo-4-chloro-3-nitropyridine
Purity
95+%
Packaging
1g
Price
$76
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142823
Product name
5-Bromo-4-chloro-3-nitropyridin-2-amine
Packaging
500mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142823
Product name
5-Bromo-4-chloro-3-nitropyridin-2-amine
Packaging
250mg
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
074513
Product name
2-Amino-5-bromo-4-chloro-3-nitropyridine
Purity
95+%
Packaging
500mg
Price
$50
Updated
2021/12/16
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2-Amino-5-bromo-4-chloro-3-nitropyridine Chemical Properties,Usage,Production

Synthesis

6980-08-1

942947-95-7

General procedure for the synthesis of 2-amino-5-bromo-4-chloro-3-nitropyridine from 2-amino-3-nitro-4-chloropyridine: 4-chloro-3-nitropyridin-2-amine (2 g, 11.5 mmol) and N-bromosuccinimide (2.5 g, 13.8 mmol) were dissolved in acetonitrile (125 mL) and heated to react for 1 hr at 80 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The product was purified by fast column chromatography (silica gel, dichloromethane/ethyl acetate gradient elution, 0-5% ethyl acetate) to afford 2-amino-5-bromo-4-chloro-3-nitropyridine (2.9 g, 99% yield). Mass spectrum (electrospray ionization): calculated value C5H3BrClN3O2, 250.9; measured value m/z 251.8 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.42 (s, 1H), 7.37 (br s, 2H).

References

[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 111
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[4] Patent: WO2013/190320, 2013, A1. Location in patent: Paragraph 00119

2-Amino-5-bromo-4-chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-bromo-4-chloro-3-nitropyridine Suppliers

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View Lastest Price from 2-Amino-5-bromo-4-chloro-3-nitropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
Price
US $1.00-1.00/Kg/Drum
Min. Order
1g
Purity
98%
Supply Ability
50tons
Release date
2020-05-12
Dideu Industries Group Limited
Product
2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-22
Career Henan Chemical Co
Product
2-Amino-5-bromo-4-chloro-3-nitropyridine 942947-95-7
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

942947-95-7, 2-Amino-5-bromo-4-chloro-3-nitropyridineRelated Search:


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  • 2-Amino-5-bromo-4-chloro-3-nitropyridine ISO 9001:2015 REACH
  • 942947-95-7
  • C5H3BrClN3O2
  • Heterocycle-Pyridine series
  • API intermediates