2-Amino-5-bromopyridine
- Product Name
- 2-Amino-5-bromopyridine
- CAS No.
- 1072-97-5
- Chemical Name
- 2-Amino-5-bromopyridine
- Synonyms
- 5-BROMOPYRIDIN-2-AMINE;5-BROMOPHTHALIDE;5-bromo-2-pyridylamine;5-BROMO-PYRIDIN-2-YLAMINE;NSC 26282;JACS-1072-97-5;AKOS BBS-00004444;TIMTEC-BB SBB003823;2-Amino-5-bromopyrid;5-Brom-2-pyridylamin
- CBNumber
- CB7403950
- Molecular Formula
- C5H5BrN2
- Formula Weight
- 173.01
- MOL File
- 1072-97-5.mol
2-Amino-5-bromopyridine Property
- Melting point:
- 133-138 °C (lit.)
- Boiling point:
- 230.9±20.0 °C(Predicted)
- Density
- 1.6065 (rough estimate)
- refractive index
- 1.5182 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.65±0.13(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- Water Solubility
- Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.
- BRN
- 108737
- InChI
- InChI=1S/C5H5BrN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
- InChIKey
- WGOLHUGPTDEKCF-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C=C1
- CAS DataBase Reference
- 1072-97-5(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Amino-5-bromopyridine (1072-97-5)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 2
- F
- 10
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 122858
- Product name
- 2-Amino-5-bromopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $58.9
- Updated
- 2025/07/31
- Product number
- 122858
- Product name
- 2-Amino-5-bromopyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $85.8
- Updated
- 2025/07/31
- Product number
- A1587
- Product name
- 2-Amino-5-bromopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- A1587
- Product name
- 2-Amino-5-bromopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $143
- Updated
- 2025/07/31
- Product number
- A601871
- Product name
- 2-Amino-5-bromopyridine
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
2-Amino-5-bromopyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Amino-5-bromopyridine is used for the synthesis of polycyclic azaarenes.
General Description
2-Amino-5-bromopyridine is a brominated aromatic amine reagent and is used for labeling of model reducing-end oligosaccharides via reductive amination.
Synthesis
39856-50-3
1072-97-5
General procedure for the synthesis of 2-amino-5-bromopyridine from 5-bromo-2-nitropyridine: 5-bromo-2-nitropyridine (0.6 mmol), 5 wt% Pd/C (0.5 mol%, 0.003 mmol), H2O (10 equiv, 6.0 mmol), B2(OH)4 (3.3 equiv, 2.0 mmol) and CH3CN ( 1.0 mL) were added to a 10 mL reaction tube. The reaction mixture was stirred at 50 °C for 24 hours. The progress of the reaction was monitored by TLC and when the reaction was complete, the mixture was cooled to room temperature. Water (5 mL) was added and extracted with EtOAc (3 x 5 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product 2-amino-5-bromopyridine (55 mg, 99% yield).
References
[1] Tetrahedron, 2017, vol. 73, # 27-28, p. 3898 - 3904
[2] Organic Process Research and Development, 2017, vol. 21, # 2, p. 247 - 252
[3] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[4] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529
[5] Yakugaku Zasshi, 1952, vol. 72, p. 381
2-Amino-5-bromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-bromopyridine manufacturers
- Product
- 2-Amino-5-bromopyridine 1072-97-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 2-Amino-5-bromopyridine 1072-97-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 2-Amino-5-bromopyridine 1072-97-5
- Price
- US $780.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 5000 Kg
- Release date
- 2025-03-28