2-Chloro-5-fluoronicotinonitrile
- Product Name
- 2-Chloro-5-fluoronicotinonitrile
- CAS No.
- 791644-48-9
- Chemical Name
- 2-Chloro-5-fluoronicotinonitrile
- Synonyms
- 2-Chloro-5-fluoropyridine-3-carbonitrile;2-Chloro-5-fluoronicotinonitrile;2-Chloro-5-fluoro-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-5-fluoro-;2-Chloro-5-fluoronicotinonitrile ISO 9001：2015 REACH
- CBNumber
- CB32516238
- Molecular Formula
- C6H2ClFN2
- Formula Weight
- 156.54
- MOL File
- 791644-48-9.mol
2-Chloro-5-fluoronicotinonitrile Property
- Boiling point:
- 235℃
- Density
- 1.43
- Flash point:
- 96℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.51±0.10(Predicted)
- form
- solid
- color
- White to off-white
- InChI
- InChI=1S/C6H2ClFN2/c7-6-4(2-9)1-5(8)3-10-6/h1,3H
- InChIKey
- SUBZTZVHVGYOPM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(F)C=C1C#N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C584723
- Product name
- 2-Chloro-5-fluoronicotinonitrile
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C584723
- Product name
- 2-Chloro-5-fluoronicotinonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584723
- Product name
- 2-Chloro-5-fluoronicotinonitrile
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C584723
- Product name
- 2-Chloro-5-fluoronicotinonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- G14274
- Product name
- 2-Chloro-5-fluoropyridine-3-carbonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
2-Chloro-5-fluoronicotinonitrile Chemical Properties,Usage,Production
Synthesis
75302-64-6
791644-48-9
Example 3A: Synthesis of 2-chloro-5-fluoronicotinonitrile 81.2 mL (582.25 mmol) of triethylamine was added to a 783 mL dichloromethane suspension containing 46.2 g (264.66 mmol) of 2-chloro-5-fluoronicotinonitrile, and the mixture was subsequently cooled to 0°C. Under continuous stirring, 41.12 mL (291.13 mmol) of trifluoroacetic anhydride was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was kept at 0 °C with continued stirring for 1.5 hours. After completion of the reaction, the reaction mixture was washed twice with saturated aqueous sodium bicarbonate (391 mL each time), and the organic phase was dried and concentrated under reduced pressure to give the crude product. The final product was 2-chloro-5-fluoronicotinonitrile with a yield of 42.1 g and 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 8.66 (dd, 1H), 8.82 (d, 1H).
References
[1] Patent: WO2013/25958, 2013, A1. Location in patent: Page/Page column 57; 58
[2] Patent: TWI609011, 2017, B. Location in patent: Page/Page column 77; 78
[3] Patent: EP2680844, 2016, B1. Location in patent: Paragraph 0134
[4] Patent: EP2744501, 2016, B1. Location in patent: Paragraph 0164; 0166
[5] Patent: TW2018/8946, 2018, A. Location in patent: Page/Page column 67
2-Chloro-5-fluoronicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-fluoronicotinonitrile manufacturers
- Product
- 2-Chloro-5-fluoronicotinonitrile 791644-48-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25