3-Amino-2-chloro-4-methylpyridine

Product Name: 3-Amino-2-chloro-4-methylpyridine
CAS No.: 133627-45-9
Chemical Name: 3-Amino-2-chloro-4-methylpyridine
Synonyms: 2-CHLORO-4-METHYLPYRIDIN-3-AMINE;2-CHLORO-3-AMINO-4-METHYLPYRIDINE;Capic;TIMTEC-BB SBB010194;3-Amino-2-chloro-4-p;ASINEX-REAG BAS 13794917;2-CHLORO-3-AMINO-4-PICOLINE;3-AMINO-2-CHLORO-4-PICOLINE;2-Chloro-3-Amino-4-Methylpyrid;2-Chlor-4-Methylpyridin-3-Amin
CBNumber: CB5240863
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 133627-45-9.mol

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3-Amino-2-chloro-4-methylpyridine Property

Melting point:: 65-70 °C
Boiling point:: 283.3±35.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform, Ethanol
pka: 3.22±0.10(Predicted)
form: Crystals
color: Off White
InChI: InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3
InChIKey: UOBCYTOUXLAABU-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C)=C1N
CAS DataBase Reference: 133627-45-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-36-39
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708135
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: 97%
Packaging: 5g
Price: $66.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 708135
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: 97%
Packaging: 1g
Price: $24
Updated: 2023/01/07

TCI Chemical

Product number: A1855
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $43
Updated: 2024/03/01

TCI Chemical

Product number: A1855
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $129
Updated: 2024/03/01

Alfa Aesar

Product number: H26058
Product name: 3-Amino-2-chloro-4-methylpyridine, 97%
Packaging: 5g
Price: $125
Updated: 2021/12/16

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3-Amino-2-chloro-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Off White Crystals

Uses

3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1.

Preparation

An improved and commercially valuable process is developed by Ge et al. for the scalable synthesis of 2-chloro-3-amino-4-methylpyridine (CAPIC), a key intermediate of Nevirapine. The synthesis was accomplished in four steps, featuring condensation starting from 4,4-dimethoxyl-2-butanone and cyanoacetamide with ammonium acetate and acetic acid as catalysts. Specifically, a stirred solution of NaOH (15.6 g, 0.39 mol) and water (85 g) at 10 ℃ was added, 10% NaClO (96.8 g, 0.13 mol) and ethanol (80 g). 2-Chloro-3-amido-4- methylpyridine 7 (22 g, 0.13 mol) was added to the reaction mixture, stirring for 1 h. The mixture was heated to 60 ℃ and held for 3 h. After ethanol was removed in a vacuum, the mixture was cooled with an ice-water bath for 15–20 min to precipitate solid. Then, the mixture was filtered, washed with water, and dried to give 15.8 g (85.1% yield) of light yellow solid. 14.7 g of the white solid 2 was obtained via recrystallization in toluene.

References

[1] Xin Ge. “A concise synthesis of 2-chloro-3-amino-4-methylpyridine.” Research on Chemical Intermediates 37 6 (2011): 599–604.

3-Amino-2-chloro-4-methylpyridine Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Hydrochloric acid 3-Amino-4-methylpyridine

Preparation Products

Nevirapine

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3-Amino-2-chloro-4-methylpyridine Suppliers

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View Lastest Price from 3-Amino-2-chloro-4-methylpyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Amino-2-chloro-4-methylpyridine 133627-45-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-09-18

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Chloro-3-amino-4-methyl pyridine 133627-45-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 3-Amino-2-chloro-4-methylpyridine 133627-45-9
Price: US $80.00-800.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

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3-Amino-2-chloro-4-methylpyridine ISO 9001：2015 REACH

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2-Chlor-4-Methylpyridin-3-Amin

2 Chloro 3 Amino 4 Methyl Pyridene

133627-45-9

133627-45

33627-45-9

C6H7C1N2

C7H4ClF3O4

Halopyridines

Chloropyridines

Building Blocks

C5 to C6

C6

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

API Intermediate

(intermediate of nevirapine)

Aromatics Compounds

Chloropyridines

Halopyridines

Aromatics

Bases & Related Reagents

Nucleotides

Pyridines, Pyrimidines, Purines and Pteredines

pharmacetical

Amines

Pyridines