4-Methylpyridin-2-amine

Product Name: 4-Methylpyridin-2-amine
CAS No.: 695-34-1
Chemical Name: 4-Methylpyridin-2-amine
Synonyms: 2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490;NSC 6972
CBNumber: CB9854129
Molecular Formula: C6H8N2
Formula Weight: 108.14
MOL File: 695-34-1.mol

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4-Methylpyridin-2-amine Property

Melting point:: 96-99 °C (lit.)
Boiling point:: 230 °C (lit.)
Density: 1.0275 (estimate)
vapor pressure: 3.71Pa at 25℃
refractive index: 1.5560 (estimate)
Flash point:: 118 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF: freely soluble
form: Flakes
pka: pK1: 7.48(+1) (25°C)
color: Slightly yellow to beige or brown
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
Merck: 14,466
BRN: 107066
LogP: 0.56-1.08
CAS DataBase Reference: 695-34-1(CAS DataBase Reference)
NIST Chemistry Reference: 2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System: 2-Pyridinamine, 4-methyl- (695-34-1)

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Safety

Hazard Codes: T
Risk Statements: 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements: 53-45-60-61-37/39-28A-26-36/37/39
RIDADR: UN 3086 6.1/PG 1
WGK Germany: 3
RTECS: TJ5150000
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29333999
Toxicity: LD50 oral in rat: 200mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 123080
Product name: 2-Amino-4-methylpyridine
Purity: 99%
Packaging: 100g
Price: $59.9
Updated: 2024/03/01

TCI Chemical

Product number: A0402
Product name: 2-Amino-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $65
Updated: 2024/03/01

TCI Chemical

Product number: A0402
Product name: 2-Amino-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $390
Updated: 2024/03/01

Alfa Aesar

Product number: A14177
Product name: 2-Amino-4-methylpyridine, 98%
Packaging: 25g
Price: $22.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14177
Product name: 2-Amino-4-methylpyridine, 98%
Packaging: 100g
Price: $32.65
Updated: 2024/03/01

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4-Methylpyridin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

4-Methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE 2-Amino-5-nitro-4-picoline 2-BROMO-3-IODO-ISONICOTINIC ACID 2-Amino-5-bromo-4-methylpyridine 2-ACETAMIDO-5-BROMOISONICOTINIC ACID 2-AMINO-ISONICOTINIC ACID HYDRAZIDE 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID 4-Pyridinecarbonyl chloride, 2-fluoro- (9CI) 2-AMINO-5-FLUORO-4-PICOLINE 2-Acetylamino-4-methylpyridine 2-Aminoisonicotinic acid Ethyl 2-Aminoisonicotinate 2-ACETAMIDO-5-NITRO-4-PICOLINE 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE (2-AMINO-PYRIDIN-4-YL)-METHANOL 2-Fluoroisonicotinic acid 2-ACETAMIDO-4-METHYL-5-BROMOPYRIDINE 2-CHLORO-3-HYDROXYISONICOTINIC ACID 2-Nitropyridine-4-carboxylic acid 2-ACETAMIDO-5-AMINO-4-PICOLINE

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4-Methylpyridin-2-amine Suppliers

Americas 1 Austria 1 Belgium 3 Canada 6 China 441 Czech Republic 1 Europe 5 France 1 Germany 9 India 61 Ireland 1 Italy 1 Japan 9 Jordan 1 Russia 1 Slovakia 1 South Korea 2 Sweden 2 Switzerland 3 The Netherlands 2 Ukraine 3 United Kingdom 19 United States 77 Global 651

Jinan Dexinjia Bio&Tech Co., Ltd

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Energy Chemical

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View Lastest Price from 4-Methylpyridin-2-amine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Methylpyridin-2-amine 695-34-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Methylpyridin-2-amine 695-34-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Amino-4-Methyl-Pyridin 695-34-1
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

695-34-1, 4-Methylpyridin-2-amineRelated Search:

4-Methylpyridin-2-amine 2-Amino-3-nitro-4-picoline 6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL HYDRAZINE 2-Amino-4-(trifluoromethyl)pyridine 2-Amino-5-bromo-4-methyl-3-nitropyridine 2-Amino-4,6-dimethylpyridine 2-Amino-5-nitro-4-picoline 2,3-Diamino-5-methylpyridine 5-Amino-3-methylpyridine 3-AMINO-2-METHOXY-6-PICOLINE 5-METHYLPYRIDIN-3-AMINE 4-AMINO-2-METHYLPYRIDINE (4-AMINO-2-PICOLINE),2-METHYLPYRIDIN-4-AMINE,4-Amino-2-methylpyridine ,97% 2-METHYLPYRIDIN-3-AMINE,3-AMINO-2-METHYLPYRIDINE (3-AMINO-2-PICOLINE),3-Amino-2-methylpyridine ,97% 2,6-DICHLORO-4-METHYLPYRIDIN-3-AMINE 2-Amino-3-ethyl-6-methylpyridine 6-Amino-5-methylpyridine-3-carbonitrile ,97%,5-Cyano-2-amino-3-methylpyridine 5-IODO-6-METHYLPYRIDIN-2-AMINE 5-Amino-2-chloro-3-picoline

2-amino-4-methyl-pyridin

2-amino-4-picolin

2-Amino-gamma-picoline

2-Aminop-4-picoline

2-Pyridinamine,4-methyl-

w45

w45raschig

4-METHYL-2-PYRIDYLAMINE

4-METHYLPYRIDIN-2-AMINE

4-METHYL-PYRIDIN-2-YLAMINE

AKOS BBS-00004343

AKOS 91145

2-AMINO-4-PICOLINE

2-AMINO-4-METHYLPYRIDINE

TIMTEC-BB SBB004354

OTAVA-BB BB7015122364

SODIUM DICHROMATE 2H2O

SODIUM DICHROMATE-2-HYDRATE

SODIUM DICHROMATE, HYDROUS

SODIUM BICHROMATE DIHYDRATE

2-amino-4-picoline;2-Amino-4-methylpyridine

AURORA 11319

2-Amino-4-Methylpyridine,Nevirapine

2-Pyridinamine,4-methyl-(9CI)

2-Amio-4-Methylpyridine

2-Amino-4-picoL

2-AMINO-4-METHYL PYRODINE

2-AMINO-4-METHYL PYRIDINE 4-METHYLPYRIDIN-2-YLAMINE

2-Amino-4-methylpyridine, 98+%

NSC 1490

NSC 176165

NSC 6972

2-AMINO-4-METHYLPYRIDINE FOR SYNTHESIS

2-Amino-4-methylpyridine ,99%

2-Amino-4-picoline,98%

2-AMino-4-picoline, 98% 100GR

2-Amino-4-picoline, 4-Methylpyridin-2-amine

4M2AP

4-Methyl-2-aminopyridine

4-Methyl-2-pyridamine

4-methyl-2-pyridinamin

4-Methyl-2-pyridinamine

4-Picoline, 2-amino-

alpha-Amino-gamma-picoline

Aminopicoline

Ascensil

component of Ascensil

component of Askensil

Methyl-4 amino-2-pyridine

methyl-4amino-2-pyridine

Pyridine, 2-amino-4-methyl-

RA 1226

ra1226

VMI 20-4

W 45

W 45 Raschig

Rifaximin EP Impurity A

Rifaximin impurity A (EP)