ChemicalBook > CAS DataBase List > 4-Methylpyridin-2-amine

4-Methylpyridin-2-amine

Product Name
4-Methylpyridin-2-amine
CAS No.
695-34-1
Chemical Name
4-Methylpyridin-2-amine
Synonyms
2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490;NSC 6972
CBNumber
CB9854129
Molecular Formula
C6H8N2
Formula Weight
108.14
MOL File
695-34-1.mol
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4-Methylpyridin-2-amine Property

Melting point:
96-99 °C (lit.)
Boiling point:
230 °C (lit.)
Density 
1.0275 (estimate)
vapor pressure 
3.71Pa at 25℃
refractive index 
1.5560 (estimate)
Flash point:
118 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMF: freely soluble
form 
Flakes
pka
pK1: 7.48(+1) (25°C)
color 
Slightly yellow to beige or brown
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,466
BRN 
107066
LogP
0.56-1.08
CAS DataBase Reference
695-34-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System
2-Pyridinamine, 4-methyl- (695-34-1)
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Safety

Hazard Codes 
T
Risk Statements 
45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements 
53-45-60-61-37/39-28A-26-36/37/39
RIDADR 
UN 3086 6.1/PG 1
WGK Germany 
3
RTECS 
TJ5150000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333999
Toxicity
LD50 oral in rat: 200mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
123080
Product name
2-Amino-4-methylpyridine
Purity
99%
Packaging
100g
Price
$59.9
Updated
2024/03/01
TCI Chemical
Product number
A0402
Product name
2-Amino-4-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
A0402
Product name
2-Amino-4-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$390
Updated
2024/03/01
Alfa Aesar
Product number
A14177
Product name
2-Amino-4-methylpyridine, 98%
Packaging
25g
Price
$22.65
Updated
2024/03/01
Alfa Aesar
Product number
A14177
Product name
2-Amino-4-methylpyridine, 98%
Packaging
100g
Price
$32.65
Updated
2024/03/01
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4-Methylpyridin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

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4-Methylpyridin-2-amine Suppliers

Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82375886 13001715031
Fax
0531-82375893
Email
3517280075@qq.com
Country
China
ProdList
1274
Advantage
58
Jubilant Life Sciences(Shanghai)Ltd.
Tel
021-63907388-21 18017369769
Email
jerry_zhang@jubl.com
Country
China
ProdList
188
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2964
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
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View Lastest Price from 4-Methylpyridin-2-amine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Methylpyridin-2-amine 695-34-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Amino-4-Methyl-Pyridin 695-34-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Hebei Weibang Biotechnology Co., Ltd
Product
4-Methylpyridin-2-amine 695-34-1
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-07

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