2-Amino-5-bromo-4-methylpyridine
- Product Name
- 2-Amino-5-bromo-4-methylpyridine
- CAS No.
- 98198-48-2
- Chemical Name
- 2-Amino-5-bromo-4-methylpyridine
- Synonyms
- 5-bromo-4-methylpyridin-2-amine;2-Amino-5-bromo-4-methyL;2-AMINO-5-BROMO-4-PICOLINE;2-AMINO-5-BROMO-GAMMA-PICOLINE;2-Amino-5-bromo-4-picoline,97%;5-Bromo-4-methyl-2-pyridinamine;2-AMINO-4-METHYL-5-BROMOPYRIDINE;2-AMINO-5-BROMO-4-METHYLPYRIDINE;5-BROMO-4-METHYL-2-PYRIDINYLAMINE;2-PyridinaMine, 5-broMo-4-Methyl-
- CBNumber
- CB0399128
- Molecular Formula
- C6H7BrN2
- Formula Weight
- 187.04
- MOL File
- 98198-48-2.mol
2-Amino-5-bromo-4-methylpyridine Property
- Melting point:
- 148-151 °C (lit.)
- Boiling point:
- 254.2±35.0 °C(Predicted)
- Density
- 1.5672 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in methanol.
- pka
- 5.27±0.24(Predicted)
- form
- Powder
- color
- Cream
- InChI
- InChI=1S/C6H7BrN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)
- InChIKey
- JDNCMHOKWINDKI-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C(C)=C1
- CAS DataBase Reference
- 98198-48-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 576786
- Product name
- 2-Amino-5-bromo-4-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $37.7
- Updated
- 2023/06/20
- Product number
- 576786
- Product name
- 2-Amino-5-bromo-4-methylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $72.8
- Updated
- 2023/06/20
- Product number
- A1897
- Product name
- 2-Amino-5-bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- A1897
- Product name
- 2-Amino-5-bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- 576786
- Product name
- 2-Amino-5-bromo-4-methylpyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $50
- Updated
- 2025/07/31
2-Amino-5-bromo-4-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Amino-5-bromo-4-methylpyridine is used as a pharmaceutical intermediate.
Synthesis
695-34-1
98198-48-2
General procedure for the synthesis of 2-amino-5-bromo-4-methylpyridine from 2-amino-4-methylpyridine: 2-amino-4-methylpyridine (0.5 mmol, 1.0 eq.), p-toluenesulfonic acid (p-TSA, 0.4 mmol, 0.8 eq.), and brominated 1-butylpyridine (1.5 mmol, 3.0 eq.) were added to a 50 mL Schlenk tube ) were added to the mixture. Under air atmosphere, 2-dimethoxyethane (2 mL) was added as solvent. Subsequently, hydrogen peroxide (H2O2, 1.2 mmol, 2.4 eq.) was slowly added to the reaction system. The reaction mixture was stirred at 80 °C for 24 hours. Upon completion of the reaction, the mixture was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate) to afford the target product 2-amino-5-bromo-4-methylpyridine.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 22, p. 7958 - 7966
[2] Tetrahedron Letters, 2014, vol. 55, # 36, p. 5058 - 5061
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 4, p. 569 - 574
[4] Synthetic Communications, 1999, vol. 29, # 1, p. 103 - 110
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
2-Amino-5-bromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-bromo-4-methylpyridine manufacturers
- Product
- 2-Amino-5-bromo-4-methylpyridine 98198-48-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Amino-5-bromo-4-methylpyridine 98198-48-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 2-Amino-5-bromo-4-methylpyridine 98198-48-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25