2-Bromo-4-methylpyridine
- Product Name
- 2-Bromo-4-methylpyridine
- CAS No.
- 4926-28-7
- Chemical Name
- 2-Bromo-4-methylpyridine
- Synonyms
- 2--4- MethylpyridinebroMide;2-BROMO-4-PICOLINE;RARECHEM AH CK 0041;-Bromo-4-methylpyridine;4-amino-2-bromppyridine;2-Bromo-4-MythylPyridine;2-BROMO-4-METHYLPYRIDINE;4-Methyl-2-bromopyridine;2-bormo-4-methylpyridine;2-BROMO-4-MEFHYL PYRIDINE
- CBNumber
- CB0250098
- Molecular Formula
- C6H6BrN
- Formula Weight
- 172.02
- MOL File
- 4926-28-7.mol
2-Bromo-4-methylpyridine Property
- Boiling point:
- 87 °C/10 mmHg (lit.)
- Density
- 1.545 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.561(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Slightly)
- pka
- 1.46±0.10(Predicted)
- form
- Liquid
- color
- Clear yellow
- Specific Gravity
- 1.545
- BRN
- 107331
- InChI
- InChI=1S/C6H6BrN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
- InChIKey
- LSZMVESSGLHDJE-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=CC(C)=C1
- CAS DataBase Reference
- 4926-28-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 349984
- Product name
- 2-Bromo-4-methylpyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- 349984
- Product name
- 2-Bromo-4-methylpyridine
- Purity
- 97%
- Packaging
- 10g
- Price
- $139
- Updated
- 2025/07/31
- Product number
- B2112
- Product name
- 2-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- B2112
- Product name
- 2-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $158
- Updated
- 2025/07/31
- Product number
- B685575
- Product name
- 2-Bromo-4-picoline
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
2-Bromo-4-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
2-Bromo-4-methylpyridine is a colorless to orange oily liquid, It decomposes to produce harmful substances such as carbon dioxide, carbon monoxide, nitrogen oxides (NOx), hydrogen bromide.
Uses
An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Uses
2-Bromo-4-methylpyridine may be used:
- in the total synthesis of ocular age pigment A2-E (2 equiv of retinal (vitamin A) and 1 equiv of ethanolamine)
- in the preparation of methoxy-2-(2-pyridyl)indoles
- in the preparation of 2-(2′,4′-difluorophenyl)-4-methylpyridine, via a Suzuki coupling reaction with 2,4-difluorophenylboronic acid
Application
2-Bromo-4-methylpyridine can be used as an intermediate in organic synthesis and medicinal chemistry, mostly in the structural modification and synthesis of drug molecules. In basic chemistry research, the substance can be used for the synthesis of a series of organic nitrogen ligands containing pyridine units, and has good applications in the basic research of methodology of transition metal catalysis.
Hazard
2-Bromo-4-methylpyridine may cause heritable genetic damage in humans.
Synthesis
695-34-1
4926-28-7
The general procedure for the synthesis of 2-bromo-4-methylpyridine from 2-amino-4-methylpyridine was as follows: 2-amino-4-methylpyridine (120 g, 1.1 mol) was dissolved in 48% hydrobromic acid (1.5 L) and bromine (160 mL, 3.11 mol) was added slowly and dropwise at -20 °C. The reaction mixture was stirred continuously for 3 hours at -15°C to -20°C. Subsequently, aqueous sodium nitrite (NaNO2) (204 g, 2.95 mol) was added to the reaction system in batches. The reaction mixture was gradually warmed up to room temperature over a period of 3 hours. A 20% aqueous sodium hydroxide (NaOH) solution (1.2 Kg NaOH dissolved in 2 L of water) was added and the pH was adjusted to 12 while the temperature was controlled at 0 °C. The reaction mixture was extracted with ether (3 x 250 mL), the organic phase was washed sequentially with water and saturated brine and dried anhydrous. After removing the solvent under reduced pressure, the reaction was purified by fractional distillation to afford 2-bromo-4-methylpyridine (164 g, 86% yield) as a light yellow liquid.
References
[1] Tetrahedron, 2002, vol. 58, # 22, p. 4429 - 4438
[2] Chemische Berichte, 1992, vol. 125, # 5, p. 1131 - 1140
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[4] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 9; 24
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 11, p. 2579 - 2587
2-Bromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4-methylpyridine manufacturers
- Product
- 2-Bromo-4-methylpyridine 4926-28-7
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000
- Release date
- 2024-09-04
- Product
- 2-Bromo-4-methylpyridine 4926-28-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 2-Bromo-4-methylpyridine 4926-28-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25