2-Bromo-5,6-diphenylpyrazine
- Product Name
- 2-Bromo-5,6-diphenylpyrazine
- CAS No.
- 243472-70-0
- Chemical Name
- 2-Bromo-5,6-diphenylpyrazine
- Synonyms
- 5-Bromo-2,3-diphenylpyrazine;Selexipag tablet 10mg;2-Bromo-5,6-diphenylpyrazine;Pyrazine, 5-bromo-2,3-diphenyl-
- CBNumber
- CB13051938
- Molecular Formula
- C16H11BrN2
- Formula Weight
- 311.18
- MOL File
- 243472-70-0.mol
2-Bromo-5,6-diphenylpyrazine Property
- Boiling point:
- 365.6±37.0 °C(Predicted)
- Density
- 1.397±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.21±0.10(Predicted)
- InChI
- InChI=1S/C16H11BrN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H
- InChIKey
- UNPRTNCCXQCEEP-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)=NC=C(Br)N=C1C1=CC=CC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5229CS
- Product name
- 5-Bromo-2,3-diphenylpyrazine
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A128302
- Product name
- 5-Bromo-2,3-diphenylpyrazine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- A128302
- Product name
- 5-Bromo-2,3-diphenylpyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- A128302
- Product name
- 5-Bromo-2,3-diphenylpyrazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2021/12/16
- Product number
- CM251637
- Product name
- 5-Bromo-2,3-diphenylpyrazine
- Purity
- 95%+
- Packaging
- 5g
- Price
- $122
- Updated
- 2021/12/16
2-Bromo-5,6-diphenylpyrazine Chemical Properties,Usage,Production
Synthesis
18591-57-6
243472-70-0
General procedure for the synthesis of 5-bromo-2,3-diphenylpyrazine from 5,6-diphenyl-2-hydroxypyrazine: 5,6-diphenyl-2-hydroxypyrazine (2.48 g, 0.01 mol) was dissolved in 20 mL of anhydrous toluene under the condition of an ice bath and phosphorus tribromide (3.24 g, 0.012 mol) was added under nitrogen protection. The reaction mixture was stirred in an ice bath for 0.5 h before being heated and refluxed for 2 h. The reaction was completed with the addition of phosphorus tribromide. After completion of the reaction, it was cooled to room temperature and most of the solvent was removed by rotary evaporation. Ethyl acetate (50 mL) and ice water (20 mL) were added to the residue and the aqueous phase was extracted with ethyl acetate (50 mL x 3). The organic phases were combined and washed sequentially with cooled sodium bicarbonate solution (100 mL), water and saturated brine (200 mL × 2). The organic phase was dried with anhydrous sodium sulfate, filtered and rotary evaporated to give the crude product 5-bromo-2,3-diphenylpyrazine as a gray solid. The crude product was recrystallized with ethyl acetate, filtered and dried in vacuum to give 2.89 g of 5-bromo-2,3-diphenylpyrazine as a white solid in 93% yield.
References
[1] Patent: CN108623541, 2018, A. Location in patent: Paragraph 0111-0113; 0126; 0130-0132
[2] Patent: CN106632093, 2017, A. Location in patent: Paragraph 0009; 0010; 0011; 0012
[3] Journal of Heterocyclic Chemistry, 1999, vol. 36, # 3, p. 783 - 786
2-Bromo-5,6-diphenylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5,6-diphenylpyrazine manufacturers
- Product
- 2-Bromo-5,6-diphenylpyrazine 243472-70-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-25
- Product
- 2-Bromo-5,6-diphenylpyrazine 243472-70-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07