2-Bromo-3-nitropyridine

Product Name: 2-Bromo-3-nitropyridine
CAS No.: 19755-53-4
Chemical Name: 2-Bromo-3-nitropyridine
Synonyms: 2-BroMo-3-nitropyrid;2-BROMO-3-NITROPYRIDINE;Pyridine, 2-bromo-3-nitro-;2-Bromo-3-nitropyridine>2-Bromo-3-nitropyridine 98%;2-Bromo-3-nitropyridine ,98%;2-BroMo-3-nitropyridine, 97+%;2-Bromo-3-nitropyridine in stock Factory;2-Bromo-3-nitropyridine ISO 9001：2015 REACH
CBNumber: CB6387769
Molecular Formula: C5H3BrN2O2
Formula Weight: 202.99
MOL File: 19755-53-4.mol

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2-Bromo-3-nitropyridine Property

Melting point:: 122-125 °C (lit.)
Boiling point:: 244.0±20.0 °C(Predicted)
Density: 1.8727 (rough estimate)
refractive index: 1.6200 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -3.24±0.10(Predicted)
color: Light orange to Yellow to Green
BRN: 124504
InChIKey: ZCCUFLITCDHRMG-UHFFFAOYSA-N
CAS DataBase Reference: 19755-53-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4193
Product name: 2-Bromo-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B4193
Product name: 2-Bromo-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $124
Updated: 2025/07/31

TRC

Product number: B694168
Product name: 2-Bromo-3-nitropyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 064561
Product name: 2-Bromo-3-nitropyridine
Packaging: 25g
Price: $282
Updated: 2021/12/16

Matrix Scientific

Product number: 064561
Product name: 2-Bromo-3-nitropyridine
Packaging: 5g
Price: $93
Updated: 2021/12/16

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2-Bromo-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Off-white to cream crystalline powder

Uses

2-Bromo-3-nitropyridine may be used in the synthesis of the following:

3-nitropyridine-2-carbonitrile
pyrrolo[3,2-b]pyridine
3-(hetero)arylated phenothiazines
7-anilino-6-azaindole-1-benznesulfonamides

General Description

2-Bromo-3-nitropyridine is a pyridine derivative. It can be synthesized from 3-nitropyridine-2-amine.

Synthesis

4214-75-9

19755-53-4

General procedure for the synthesis of 2-bromo-3-nitropyridine from 2-amino-3-nitropyridine: 3-nitropyridin-2-amine (1.0 g, 7.19 mmol) was dissolved in 35 mL of DMSO, KNO2 (2.45 g, 28.75 mmol) and CuBr (0.206 g, 1.44 mmol) were added. A 48% aqueous HBr solution (3.60 mL, 32.0 mmol) dissolved in DMSO (35 mL) was slowly added dropwise to the above mixture at 35 °C. After the dropwise addition was completed, the reaction mixture was stirred at 35°C for 4 hours. Subsequently, the reaction solution was transferred to 100 mL of ice water solution containing K2CO3 (7 g). The reaction mixture was extracted with ether, the ether layer was washed with water and dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: 100% dichloromethane) to afford 2-bromo-3-nitropyridine as a beige powder (0.662 g, 45% yield). Thin-layer chromatography Rf value was 0.75 (dichloromethane); melting point was 121-122 °C (literature value: 123-124 °C); IR (KBr) νmax (cm-1): 3042 (νCHar), 1578 and 1562 (νC=C), 1524 (νasNO2), 1350 (νsyNO2); 1H NMR (400 MHz. DMSO-d6): δ 8.73 (dd, 1H, J1=1.6Hz, J2=4.8Hz, H-6), 8.54 (dd, 1H, J1=1.6Hz, J3=8.0Hz, H-4), 7.79 (dd, 1H, J2=4.8Hz, J3=8.0Hz, H-5); 13C NMR (100MHz, DMSO -d6): δ 153.26 (C-6), 147.08 (C-3), 134.48 (C-4), 132.08 (C-2), 124.44 (C-5); MS (ESI) m/z (%): 202.9 (100) [M+H]+, 204.9 (100) [M+H+2]+. Calculated elemental analysis (C5H3BrN2O2): C, 29.58; H, 1.49; N, 13.80. measured values: C, 29.63; H, 1.50; N, 13.83.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 171 - 183
[2] Tetrahedron, 2002, vol. 58, # 17, p. 3323 - 3328
[3] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219

2-Bromo-3-nitropyridine Preparation Products And Raw materials

Raw materials

3-Nitro-2-pyridinol Phosphorus oxybromide Ethyl acetate Phosphorus tribromide PETROLEUM ETHER

Preparation Products

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2-Bromo-3-nitropyridine Suppliers

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View Lastest Price from 2-Bromo-3-nitropyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Bromo-3-nitropyridine 19755-53-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

Chemwill Asia Co.,Ltd.

Product: 2-Bromo-3-nitropyridine in stock Factory 19755-53-4
Price: US $2.00/kg
Min. Order: 1 KG/Drum
Purity: High quality purified Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 2-Bromo-3-nitropyridine 19755-53-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

19755-53-4, 2-Bromo-3-nitropyridineRelated Search:

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2-BROMO-3-NITROPYRIDINE

2-Bromo-3-nitropyridine in stock Factory

2-Bromo-3-nitropyridine ,98%

2-Bromo-3-nitropyridine 98%

2-BroMo-3-nitropyrid

2-BroMo-3-nitropyridine, 97+%

2-Bromo-3-nitropyridine&gt

Pyridine, 2-bromo-3-nitro-

2-Bromo-3-nitropyridine ISO 9001：2015 REACH

19755-53-4

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