2-Bromo-4-methylpyridine

Product Name: 2-Bromo-4-methylpyridine
CAS No.: 4926-28-7
Chemical Name: 2-Bromo-4-methylpyridine
Synonyms: 2--4- MethylpyridinebroMide;2-BROMO-4-PICOLINE;RARECHEM AH CK 0041;-Bromo-4-methylpyridine;4-amino-2-bromppyridine;2-Bromo-4-MythylPyridine;2-BROMO-4-METHYLPYRIDINE;4-Methyl-2-bromopyridine;2-bormo-4-methylpyridine;2-BROMO-4-MEFHYL PYRIDINE
CBNumber: CB0250098
Molecular Formula: C6H6BrN
Formula Weight: 172.02
MOL File: 4926-28-7.mol

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2-Bromo-4-methylpyridine Property

Boiling point:: 87 °C/10 mmHg (lit.)
Density: 1.545 g/mL at 25 °C (lit.)
refractive index: n20/D 1.561(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol (Slightly)
pka: 1.46±0.10(Predicted)
form: Liquid
color: Clear yellow
Specific Gravity: 1.545
BRN: 107331
InChI: InChI=1S/C6H6BrN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
InChIKey: LSZMVESSGLHDJE-UHFFFAOYSA-N
SMILES: C1(Br)=NC=CC(C)=C1
CAS DataBase Reference: 4926-28-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 349984
Product name: 2-Bromo-4-methylpyridine
Purity: 97%
Packaging: 1g
Price: $26.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 349984
Product name: 2-Bromo-4-methylpyridine
Purity: 97%
Packaging: 10g
Price: $139
Updated: 2025/07/31

TCI Chemical

Product number: B2112
Product name: 2-Bromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: B2112
Product name: 2-Bromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $158
Updated: 2025/07/31

TRC

Product number: B685575
Product name: 2-Bromo-4-picoline
Packaging: 5g
Price: $140
Updated: 2021/12/16

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2-Bromo-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

2-Bromo-4-methylpyridine is a colorless to orange oily liquid, It decomposes to produce harmful substances such as carbon dioxide, carbon monoxide, nitrogen oxides (NOx), hydrogen bromide.

Uses

An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity

Uses

2-Bromo-4-methylpyridine may be used:

in the total synthesis of ocular age pigment A2-E (2 equiv of retinal (vitamin A) and 1 equiv of ethanolamine)
in the preparation of methoxy-2-(2-pyridyl)indoles
in the preparation of 2-(2′,4′-difluorophenyl)-4-methylpyridine, via a Suzuki coupling reaction with 2,4-difluorophenylboronic acid

Application

2-Bromo-4-methylpyridine can be used as an intermediate in organic synthesis and medicinal chemistry, mostly in the structural modification and synthesis of drug molecules. In basic chemistry research, the substance can be used for the synthesis of a series of organic nitrogen ligands containing pyridine units, and has good applications in the basic research of methodology of transition metal catalysis.

Hazard

2-Bromo-4-methylpyridine may cause heritable genetic damage in humans.

Synthesis

695-34-1

4926-28-7

The general procedure for the synthesis of 2-bromo-4-methylpyridine from 2-amino-4-methylpyridine was as follows: 2-amino-4-methylpyridine (120 g, 1.1 mol) was dissolved in 48% hydrobromic acid (1.5 L) and bromine (160 mL, 3.11 mol) was added slowly and dropwise at -20 °C. The reaction mixture was stirred continuously for 3 hours at -15°C to -20°C. Subsequently, aqueous sodium nitrite (NaNO2) (204 g, 2.95 mol) was added to the reaction system in batches. The reaction mixture was gradually warmed up to room temperature over a period of 3 hours. A 20% aqueous sodium hydroxide (NaOH) solution (1.2 Kg NaOH dissolved in 2 L of water) was added and the pH was adjusted to 12 while the temperature was controlled at 0 °C. The reaction mixture was extracted with ether (3 x 250 mL), the organic phase was washed sequentially with water and saturated brine and dried anhydrous. After removing the solvent under reduced pressure, the reaction was purified by fractional distillation to afford 2-bromo-4-methylpyridine (164 g, 86% yield) as a light yellow liquid.

References

[1] Tetrahedron, 2002, vol. 58, # 22, p. 4429 - 4438
[2] Chemische Berichte, 1992, vol. 125, # 5, p. 1131 - 1140
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[4] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 9; 24
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 11, p. 2579 - 2587

2-Bromo-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Bromopyridine-4-carboxylic acid 2-Bromo-4-pyridinecarboxaldehyde

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2-Bromo-4-methylpyridine Suppliers

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View Lastest Price from 2-Bromo-4-methylpyridine manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 2-Bromo-4-methylpyridine 4926-28-7
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000
Release date: 2024-09-04

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-4-methylpyridine 4926-28-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Dideu Industries Group Limited

Product: 2-Bromo-4-methylpyridine 4926-28-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-25

4926-28-7, 2-Bromo-4-methylpyridineRelated Search:

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2--4- MethylpyridinebroMide

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2-Bromo-4-methylpyridine,96%

RARECHEM AH CK 0041

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2-Bromo-4-MythylPyridine

2-BROMO-4-MEFHYL PYRIDINE

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2-BROMO-4-PICOLINE

-Bromo-4-methylpyridine

2-BROMO-4-METHYLPYRIDINE (2-BROMO-4-PICOLINE)

2-Bromo-4-methylpyridine ,98%

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2-Bromo-4-methylpyridine&gt

2-Bromo-4-methylpyridine ISO 9001：2015 REACH

4-amino-2-bromppyridine

2-Bromo-4-methylpyridine, 95%

4926-28-7

4923-28-7

Pyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Halopyridines

Bromopyridines

Building Blocks

alkyl bromide

Aromatics

Heterocycles

Bromopyridines

Halopyridines

Boronic Acid

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Brominated heterocyclic series

Pyridines, Pyrimidines, Purines and Pteredines

Pyridine Series

Pyridine

pyridine derivative

compounds of pyridine

bc0001