ChemicalBook > CAS DataBase List > 2-Amino-5-bromo-4-methylpyridine

2-Amino-5-bromo-4-methylpyridine

Product Name
2-Amino-5-bromo-4-methylpyridine
CAS No.
98198-48-2
Chemical Name
2-Amino-5-bromo-4-methylpyridine
Synonyms
5-bromo-4-methylpyridin-2-amine;2-Amino-5-bromo-4-methyL;2-AMINO-5-BROMO-4-PICOLINE;2-AMINO-5-BROMO-GAMMA-PICOLINE;2-Amino-5-bromo-4-picoline,97%;5-Bromo-4-methyl-2-pyridinamine;2-AMINO-4-METHYL-5-BROMOPYRIDINE;2-AMINO-5-BROMO-4-METHYLPYRIDINE;5-BROMO-4-METHYL-2-PYRIDINYLAMINE;2-PyridinaMine, 5-broMo-4-Methyl-
CBNumber
CB0399128
Molecular Formula
C6H7BrN2
Formula Weight
187.04
MOL File
98198-48-2.mol
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2-Amino-5-bromo-4-methylpyridine Property

Melting point:
148-151 °C (lit.)
Boiling point:
254.2±35.0 °C(Predicted)
Density 
1.5672 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in methanol.
pka
5.27±0.24(Predicted)
form 
Powder
color 
Cream
InChI
InChI=1S/C6H7BrN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)
InChIKey
JDNCMHOKWINDKI-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C(C)=C1
CAS DataBase Reference
98198-48-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
576786
Product name
2-Amino-5-bromo-4-methylpyridine
Purity
98%
Packaging
1g
Price
$37.7
Updated
2023/06/20
Sigma-Aldrich
Product number
576786
Product name
2-Amino-5-bromo-4-methylpyridine
Purity
98%
Packaging
5g
Price
$72.8
Updated
2023/06/20
TCI Chemical
Product number
A1897
Product name
2-Amino-5-bromo-4-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
A1897
Product name
2-Amino-5-bromo-4-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$45
Updated
2025/07/31
Sigma-Aldrich
Product number
576786
Product name
2-Amino-5-bromo-4-methylpyridine
Purity
98%
Packaging
25g
Price
$50
Updated
2025/07/31
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2-Amino-5-bromo-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-5-bromo-4-methylpyridine is used as a pharmaceutical intermediate.

Synthesis

695-34-1

98198-48-2

General procedure for the synthesis of 2-amino-5-bromo-4-methylpyridine from 2-amino-4-methylpyridine: 2-amino-4-methylpyridine (0.5 mmol, 1.0 eq.), p-toluenesulfonic acid (p-TSA, 0.4 mmol, 0.8 eq.), and brominated 1-butylpyridine (1.5 mmol, 3.0 eq.) were added to a 50 mL Schlenk tube ) were added to the mixture. Under air atmosphere, 2-dimethoxyethane (2 mL) was added as solvent. Subsequently, hydrogen peroxide (H2O2, 1.2 mmol, 2.4 eq.) was slowly added to the reaction system. The reaction mixture was stirred at 80 °C for 24 hours. Upon completion of the reaction, the mixture was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate) to afford the target product 2-amino-5-bromo-4-methylpyridine.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 22, p. 7958 - 7966
[2] Tetrahedron Letters, 2014, vol. 55, # 36, p. 5058 - 5061
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 4, p. 569 - 574
[4] Synthetic Communications, 1999, vol. 29, # 1, p. 103 - 110
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175

2-Amino-5-bromo-4-methylpyridine Preparation Products And Raw materials

Raw materials

Bromine Acetic acid 4-Methylpyridin-2-amine

Preparation Products

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2-Amino-5-bromo-4-methylpyridine Suppliers

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View Lastest Price from 2-Amino-5-bromo-4-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-5-bromo-4-methylpyridine 98198-48-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Fengda Chemical Co., Ltd
Product
2-Amino-5-bromo-4-methylpyridine 98198-48-2
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-31
Dideu Industries Group Limited
Product
2-Amino-5-bromo-4-methylpyridine 98198-48-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-25

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  • 98198-48-2
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  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Building Blocks
  • Halopyridines
  • Bromopyridines
  • Amino-pyridine series
  • Bromopyridines
  • Halopyridines
  • Boronic Acid
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Amines
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • 1